Ask about this productRelated genes to: MPP5 Blocking Peptide
- Gene:
- MPP5 NIH gene
- Name:
- membrane palmitoylated protein 5
- Previous symbol:
- -
- Synonyms:
- PALS1, FLJ12615
- Chromosome:
- 14q23.3
- Locus Type:
- gene with protein product
- Date approved:
- 2002-05-23
- Date modifiied:
- 2016-04-01
Related products to: MPP5 Blocking Peptide
Related articles to: MPP5 Blocking Peptide
- Radiotherapy is a primary treatment for intermediate and advanced cervical cancer (CC). Resistance to radiotherapy is a principal reason for treatment failure in synchronous applications, yet the molecular mechanisms remain poorly understood. Identifying reliable prognostic markers to predict and evaluate patient outcomes is essential for advancing therapeutic strategies. This study aims to address this need by developing a prognostic prediction model for concurrent radiotherapy in CC, utilizing both single-cell RNA sequencing (scRNA-seq) and bulk RNA sequencing data. - Source: PubMed
Publication date: 2025/10/31
Yang SiqiLiu LitingSu QiuyueWang JiananXia JingqiZhao XinyaoSun YajuanYang Shanshan - Signal-induced proliferation-associated 1 like 3 (SIPA1L3) is a member of the protein family. Very limited data are currently available regarding the role of SIPA1L3 in human carcinoma. Therefore, in this study, we investigated the expression pattern and function of SIPA1L3 in non-small cell lung cancer (NSCLC). - Source: PubMed
Wang LinWang Bin-XueZhang RuiXian Si-HanWang Si - Urine samples are non-invasive approaches to study potential circulating biomarkers from the host organism. Specific proteins cross the bloodstream through the intestinal barrier and may also derive from gut microbiota. In this study, we aimed to evaluate the predictive role of the host and bacterial urine extracellular vesicle (EV) proteomes in patients with non-small cell lung cancer (NSCLC) treated with anti-PD1 immunotherapy. - Source: PubMed
Publication date: 2025/04/14
Dora DavidRevisnyei PeterPasic AlijaGalffy GabriellaDulka EditMihucz AnnaRoskó BrigittaSzincsak SaraIliuk AntonWeiss Glen JLohinai Zoltan - The oncogenes yes-associated protein () and transcriptional coactivator with PDZ-binding motif () are potent liver oncogenes. Because gene mutations cannot fully explain their nuclear enrichment, we aim to understand which mechanisms cause activation in liver cancer cells. The combination of proteomics and functional screening identified numerous apical cell polarity complex proteins interacting with YAP and TAZ. Co-immunoprecipitation (Co-IP) experiments confirmed that membrane protein palmitoylated 5 (MPP5; synonym: PALS1) physically interacts with YAP and TAZ. After removing different MPP5 protein domains, Co-IP analyses revealed that the PDZ domain plays a crucial role in YAP binding. The interaction between YAP and MPP5 in the cytoplasm of cancer cells was demonstrated by proximity ligation assays (PLAs). In human hepatocellular carcinoma (HCC) tissues, a reduction in apical MPP5 expression was observed, correlating with the nuclear accumulation of YAP and TAZ. Expression data analysis illustrated that is inversely associated with YAP/TAZ target gene signatures in human HCCs. Low levels define an HCC patient group with a poor clinical outcome. In summary, MPP5 facilitates the nuclear exclusion of YAP and TAZ in liver cancer. This qualifies MPP5 as a potential tumor-suppressor gene and explains how changes in cell polarity can foster tumorigenesis. - Source: PubMed
Publication date: 2025/01/14
Tóth MarcellWan ShanSchmitt JenniferBirner PatriziaWei Tengvon Bubnoff Fabiande la Torre CarolinaThomann StefanPinna FedericoSchirmacher PeterWeiler Sofia Maria ElisabethBreuhahn Kai - Mango, a tropical fruit celebrated for its delightful fragrance and high nutritional value, generates significant waste during processing, with approximately 35-60% of the fruit being discarded. However, this waste contains valuable components, such as fibre, carotenoids, polyphenols, and other bioactive compounds. In an effort to repurpose mango peel, this study dehydrated it to create mango peel powder (MPP), which was then incorporated into sourdough bread to produce functional breads with enhanced nutritional value. Semolina was replaced with MPP at levels of 5% (MPP-5) and 10% (MPP-10) (/). After dehydration, the mango peel had a yield of 22%, and the procedure used did not cause any organoleptic changes. The bread fermentation process was conducted at 30 °C for 8 h. During dough fermentation, the pH was monitored, showing a value of 4.14 ± 0.02 in the MPP-10 dough. Overall, the MPP-10 bread received a higher score (6.51) than the control (CTR) bread (5.6) and the MPP-5 bread (6.11). The total phenolic content of the fortified breads ranged from 44.760 to 98.931 mg gallic acid equivalents (GAE)/g, and the antiradical activity ranged from 15.213 to 29.461 mmol trolox equivalent antioxidant activity (TEAC)/100 g, depending on the percentage of enrichment. - Source: PubMed
Publication date: 2024/10/23
Chulibert María EugeniaRoppolo PasqualeBuzzanca CarlaAlfonzo AntonioViola EnricoSciurba LinoTinebra IleniaD'Amico AngelaFarina VittorioPiazzese DanielaDi Stefano VitaBarbera MarcellaGaglio RaimondoSettanni Luca