Ask about this productRelated genes to: Ambp Blocking Peptide
- Gene:
- AMBP NIH gene
- Name:
- alpha-1-microglobulin/bikunin precursor
- Previous symbol:
- ITI, ITIL
- Synonyms:
- UTI, HCP, EDC1, HI30, IATIL, ITILC
- Chromosome:
- 9q32
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2016-10-05
Related products to: Ambp Blocking Peptide
Related articles to: Ambp Blocking Peptide
- Proximal tubule dysfunction in the kidney is associated with cardiovascular disease (CVD) in populations with prevalent chronic kidney disease (CKD). We sought to evaluate the nature of this association in the general population. - Source: PubMed
Publication date: 2026/06/02
Ikeme Jesse CKatz RonitØvrehus Marius ALanglo Knut Asbjørn REstrella Michelle MShlipak Michael GIx Joachim HHallan Stein I - Isometric resistance training (IRT) can reduce resting and ambulatory blood pressure (AmBP) yet established exercise methods lack versatility and may present with participation barriers. An isometric training band (ITB) has been identified as an alternative modality; however, its long-term effects on resting and ambulatory blood pressure (BP) remains unknown. This study assessed the effects of the ITB on resting BP and AmBP following 4 weeks of IRT. Forty-two normotensive adults (22 male, 20 female; mean ± SD, age 31 ± 14 years, systolic [sBP], 120 ± 5 mmHg, diastolic [dBP], 72 ± 7 mmHg), were randomised to a control (CON), isometric handgrip (IHG) or ITB group. Resting (systolic, diastolic, mean arterial BP and heart rate [HR]) and AmBP (24-h, daytime and night-time) were measured pre- and post-4 weeks of supervised IRT (4 x 2-min contractions at 30% MVC [IHG] or 4 x 2-min contractions at CR-10 values equivalent to 30% MVC [ITB]). Resting sBP was reduced for IHG (-4.6 mmHg, p < 0.05) and ITB (-4.5 mmHg, p < 0.05) following 4 weeks of IRT, alongside significant within-group differences in night-time sBP for both training groups (ITB -4 mmHg, IHG, -4.7 mmHg). No differences were seen within or between groups for resting dBP, mBP, HR and 24-h and daytime AmBP (p > 0.05 across all measures). These findings suggest 4 weeks of IRT using the ITB can elicit reductions in resting BP and night-time AmBP in normotensives comparable to IHG, indicating the ITB may offer a practical and cost-effective alternative to established interventions. - Source: PubMed
Wright Ben HAntrobus Mark RJones Peter G WBaross Anthony W - Weaning stress is a prevalent pathological condition in pig farming, primarily triggered by factors such as nutritional imbalance, oxidative stress, inflammation, and bacterial infections. In this study, response surface methodology was first employed to optimize the preparation process of Codonopsis pilosula-Glycyrrhiza uralensis extract (CGe). Dietary supplementation with CGe for 28 days revealed that 1% CGe significantly increased the growth performance of weaned piglets, enhanced antioxidant capacity, and promoted intestinal microbiota balance, demonstrating a favorable safety profile. Subsequently, by integrating Gene Expression Omnibus (GEO) database mining with machine learning, we identified cathepsin D (CTSD), alpha-1-microglobulin/bikunin precursor (AMBP), and prosaposin (PSAP) as potential biomarkers of weaning stress. Among these biomarkers, AMBP showed significant positive correlations with M0 macrophages, mast cells, and neutrophils, and a negative correlation with M1 macrophages, suggesting its involvement in macrophage polarization during weaning stress. Molecular docking and molecular dynamics simulations further revealed that liquiritin, a key bioactive component of CGe, formed a stable interaction with AMBP and exhibited low binding energy. This interaction likely underpins its potential to mediate anti-inflammatory and anti-oxidant effects. These results indicate that AMBP is a promising target for alleviating weaning stress, and CGe has potential as an eco-friendly feed additive for improving the health of weaned piglets. - Source: PubMed
Publication date: 2026/06/05
Cai YanziJiang LidongYang SanhangZhang FengyuHua YongliJi PengYuan ZiwenWei Yanming - Urine alpha-1-microglobulin protein is a sensitive biomarker for detecting damage in the proximal renal tubules. Free kappa light chains may also be elevated in tubular damage of any origin. The aim of this study was to evaluate whether the detection of free kappa light chains in urine could show earlier tubular damage than alpha-1-microglobulin. - Source: PubMed
Publication date: 2026/06/02
Parejo Martín AlfonsoCarande Del Río María TRobles Nicolas RGómez Vera SergioFernández Cavada María JesúsXavier Aller CristinaSacristán Enciso BeatrizLópez Gómez Juan - Approximately one in five patients undergoing coronary artery bypass graft (CABG) surgery will develop post-operative acute kidney injury (AKI). We sought to determine whether biomarkers of kidney tubule dysfunction and injury are associated with long-term risk of acute kidney injury (AKI) after coronary artery bypass graft (CABG) surgery. - Source: PubMed
Publication date: 2026/06/01
Shingler LaurenTamhane AshutoshChu Ching-MinFrey Jennifer ALevitan Emily BJudd Suzanne EBullen Alexander LSiew Edward DBonventre Joseph VShlipak Michael GJaeger ByronSeegmiller Jesse CKeister AlexanderGutierrez Orlando MIx Joachim HWang Henry E