Ask about this productRelated genes to: SOAT1 Blocking Peptide
- Gene:
- SOAT1 NIH gene
- Name:
- sterol O-acyltransferase 1
- Previous symbol:
- SOAT, STAT
- Synonyms:
- ACAT
- Chromosome:
- 1q25.2
- Locus Type:
- gene with protein product
- Date approved:
- 1998-11-04
- Date modifiied:
- 2016-10-05
Related products to: SOAT1 Blocking Peptide
Related articles to: SOAT1 Blocking Peptide
- Meibomian glands (MGs) produce lipids that stabilize the tear film and maintain ocular surface homeostasis. Dysfunction of MG lipid secretion is a major cause of evaporative dry eye (EDE). The purpose of this study was to test whether pharmacologic modulation of meibum lipid biosynthesis could improve the physicochemical properties of meibum and thereby slow the progression of EDE in a mouse model of the disease. - Source: PubMed
Widjaja-Adhi Made Airanthi KChung ChloeLapierre-Landry MaryseChao KarinaLu Eric YSwigris JaclynWalczak-Szeffer AnnaGolczak WiktorSayegh Rony RJenkins Michael WGolczak Marcin - This study aims to investigate the association between sterol O-acyltransferase 1 (SOAT1) expression and patient prognosis, immune environment, and biochemical indicators in glioma. - Source: PubMed
Publication date: 2026/06/16
Hu WeihuaLiang WulongGuo XuyangWang FangyuanJing ZhouLu BingqiLi HaoZhou ShaolongHuo AoZhao ChenglinWang QingyiLiang ShipengFu XudongWang Xinjun - Adrenocortical carcinoma (ACC) is a rare but aggressive endocrine tumor (incidence 0.7-2.0 per million per year) with a 5-year survival rate of less than 15% at the European Network for the Study of Adrenal Tumors stage IV. The standard diagnostic workup in clinical chemistry laboratories for the detection of functional tumors (serum cortisol, DHEAS, and 24 h urinary free cortisol) and the Weiss/Helsinki histological scoring system cannot detect non-functioning tumors, lacks a standardized approach for predicting prognosis, and does not have a validated minimal-residual-disease marker for postoperative monitoring. This narrative review evaluated 246 original research publications on four multi-omic layers in relation to clinical laboratories. Genomic and transcriptomic analyses, including TCGA-ACC pan-genomic profiling, revealed recurrent driver mutations and prognostic molecular subtypes that outperform the ENSAT staging. Tissue and circulating proteomic analyses identified HNRNPA1, KPNA2, SOAT1, and plasma AgRP as diagnostic and pharmacoproteomic targets. Urinary and serum steroid metabolomics (GC-MS and liquid chromatography-tandem mass spectrometry) validated in a 2017-patient prospective EURINE-ACT cohort provided clinically actionable diagnostic accuracy of over 85% and proved informative for post-surgical recurrence monitoring. Multi-omics classification consistently identifies two distinct biologically based subtypes with therapeutic implications. We also discuss the pre-analytical, analytical, and inter-laboratory standardization requirements that must be met before each biomarker layer can be translated to the clinical chemistry laboratory and advocate a multi-omic implementation strategy for ACC diagnosis, prognosis, and recurrence detection. - Source: PubMed
Publication date: 2026/05/20
Gupta GPatil Deepa JattiPatel Jalpa RS Renuka JyothiShefali Karmakar RachanPant KumudBhopate KiranSingh Sujeet KumarAlmalki Waleed Hassan - Efficient lipid mobilization from yolk is critical for avian embryonic development, yet the cellular mechanisms governing lipoprotein transport in yolk sac membrane endodermal epithelial cells remain poorly characterized. Single-cell RNA sequencing was performed on 9,037 embryonic day 4 and 6,884 embryonic day 7 chicken yolk sac membrane cells to investigate lipoprotein biosynthesis pathways. Analysis identified 17 transcriptionally distinct clusters, including 3 endodermal epithelial cell subtypes. Cluster 2, characterized by high expression of epithelial markers (CDH1, EPCAM) and HDL biosynthesis genes (APOA1, ABCA1, LCAT), emerged as the primary site of HDL assembly. Apolipoprotein A1 ranked third in expression whereas apolipoprotein B ranked only 63rd, indicating a prominent HDL-biogenesis program in EECs. Gene ontology enrichment revealed upregulation of cholesterol metabolism and lipoprotein particle receptor binding pathways from embryonic day 4 to 7. Temporal expression analysis demonstrated progressive increases in HDL-related genes (APOA1, ABCA1, LCAT, SOAT1) throughout incubation, peaking at embryonic day 20, while VLDL-related genes (APOB, MTTP, SAR1B) showed sustained upregulation. Plasma analysis at embryonic day 19 confirmed HDL concentration (194.78 ± 30.13 mg/mL, mean ± SEM) significantly exceeded VLDL concentration (65.43 ± 13.82 mg/mL; P < 0.01), representing approximately 75% of measured lipoproteins. These findings reveal that HDL, rather than VLDL alone, plays a substantial role in lipid redistribution during late chicken embryogenesis, with HDL serving as the primary carrier of cholesteryl esters and phospholipids while VLDL remains the dominant triacylglycerol transporter, highlighting complementary lipoprotein functions and species-specific metabolic adaptations critical for embryonic development. - Source: PubMed
Publication date: 2026/04/17
Wu Jie-CiHu Zhao-QiLin Yuan-YuMersmann Harry JDing Shih-Torng - Macrophage polarization correlates strongly with the progression and prognosis of spinal cord injury (SCI), yet the therapeutic potential of macrophage polarization-related genes (MPRGs) in SCI remains unexplored. This study identified hub genes associated with MPRGs for SCI diagnosis, prognosis, and therapy. Differentially expressed genes (DEGs) between SCI and control groups were intersected with MPRGs to identify six differentially expressed MPRGs (DE-MPRGs). Machine learning algorithms, including LASSO, RF, and XGBoost, selected three hub genes (Soat1, Comt, and Myo1f) with elevated expression in SCI samples. Functional enrichment analysis indicated involvement in immune-related pathways. Immune infiltration analysis revealed differences in 11 immune gene sets between SCI and controls, all positively correlated with the hub genes. In silico drug prediction identified 37 small molecules, including dexamethasone and atorvastatin, as potential modulators of macrophage polarization in SCI. Single-cell RNA sequencing showed significantly higher expression of all hub genes in M2 than in M1 macrophages. RT-qPCR validation confirmed upregulation of the hub genes in SCI models. These results highlight Soat1, Comt, and Myo1f as novel hub genes in SCI, offering insights into macrophage polarization mechanisms and potential therapeutic targets. - Source: PubMed
Publication date: 2026/05/04
Zha XiaoweiCao Shen