Ask about this productRelated genes to: ANKRD13D Blocking Peptide
- Gene:
- ANKRD13D NIH gene
- Name:
- ankyrin repeat domain 13D
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 11q13.2
- Locus Type:
- gene with protein product
- Date approved:
- 2005-07-18
- Date modifiied:
- 2016-06-02
Related products to: ANKRD13D Blocking Peptide
Related articles to: ANKRD13D Blocking Peptide
- BACKGROUND: The role of neddylation in colorectal cancer (CRC) is increasingly recognized as a significant factor. Our study employed bioinformatics analysis to investigate the functions of neddylation-related genes in CRC. METHODS: Transcriptome data from multiple public databases were integrated and analyzed using a comprehensive bioinformatics approach, including differential expression analysis, weighted gene co-expression network analysis, and machine learning tactics to identify prognostic genes. These genes were then implemented to establish a risk prediction model. Single-cell RNA sequencing (scRNA-seq) was utilized to reveal the distribution and interactions of various cell types. The characteristics of immune cell infiltration were assessed by immune infiltration analysis. Finally, the functional roles of the prognostic gene were validated through the wound healing assay, cell counting kit-8, and transwell assay. RESULTS: Three genes—CCNF, ANKRD13D, and PSMA7—were identified as prognostic markers. The risk prediction model built on these genes demonstrated modest predictive performance, with the area under the curve values exceeding 0.6 at 3, 5, and 7 years. Immune infiltration analysis showed that the infiltration levels of 15 immune cells, including plasmacytoid dendritic cells and eosinophil, were markedly higher in the high-risk cohort. Furthermore, scRNA-seq data indicated that M1 macrophages exhibited higher scores for the neddylation gene set in CRC. Experimental validation demonstrated that knockdown of ANKRD13D inhibits cell proliferation, migration, and invasion. CONCLUSION: This study established a preliminary prognostic risk model based on CCNF, ANKRD13D, and PSMA7, which exhibits exploratory predictive value for CRC prognosis. These results identified CCNF, ANKRD13D, and PSMA7 as potential candidate biomarkers for prognostic assessment in CRC. - Source: PubMed
Publication date: 2025/11/24
Zhou LiPan LujuanLan HaishengGuo HoujiHuang XusenLi HuaTang Qianli - The correlation of the expression of ankyrin repeat domain (ANKRD) family members with renal cell carcinoma prognosis was investigated. - Source: PubMed
Publication date: 2024/03/06
Zhou WenqianHuang YongheLiu JingLiu YiguoLiu YuqingYu Chen - Omega-3 (n-3) and omega-6 (n-6) polyunsaturated fatty acids (PUFAs) play critical roles in human health. Prior genome-wide association studies (GWAS) of n-3 and n-6 PUFAs in European Americans from the CHARGE Consortium have documented strong genetic signals in/near the FADS locus on chromosome 11. We performed a GWAS of four n-3 and four n-6 PUFAs in Hispanic American (n = 1454) and African American (n = 2278) participants from three CHARGE cohorts. Applying a genome-wide significance threshold of P < 5 × 10, we confirmed association of the FADS signal and found evidence of two additional signals (in DAGLA and BEST1) within 200 kb of the originally reported FADS signal. Outside of the FADS region, we identified novel signals for arachidonic acid (AA) in Hispanic Americans located in/near genes including TMX2, SLC29A2, ANKRD13D and POLD4, and spanning a > 9 Mb region on chromosome 11 (57.5 Mb ~ 67.1 Mb). Among these novel signals, we found associations unique to Hispanic Americans, including rs28364240, a POLD4 missense variant for AA that is common in CHARGE Hispanic Americans but absent in other race/ancestry groups. Our study sheds light on the genetics of PUFAs and the value of investigating complex trait genetics across diverse ancestry populations. - Source: PubMed
Publication date: 2023/08/16
Yang ChaojieVeenstra JennaBartz Traci MPahl Matthew CHallmark BrianChen Yii-Der IdaWestra JasonSteffen Lyn MBrown Christopher DSiscovick DavidTsai Michael YWood Alexis CRich Stephen SSmith Caren EO'Connor Timothy DMozaffarian DariushGrant Struan F AChilton Floyd HTintle Nathan LLemaitre Rozenn NManichaikul Ani - Omega-3 (n-3) and omega-6 (n-6) polyunsaturated fatty acids (PUFAs) play critical roles in human health. Prior genome-wide association studies (GWAS) of n-3 and n-6 PUFAs in European Americans from the CHARGE Consortium have documented strong genetic signals in/near the locus on chromosome 11. We performed a GWAS of four n-3 and four n-6 PUFAs in Hispanic American (n = 1454) and African American (n = 2278) participants from three CHARGE cohorts. Applying a genome-wide significance threshold of < 5 x 10 , we confirmed association of the signal and found evidence of two additional signals (in and ) within 200 kb of the originally reported signal. Outside of the region, we identified novel signals for arachidonic acid (AA) in Hispanic Americans located in/near genes including , , and spanning a > 9 Mb region on chromosome 11 (57.5Mb ~ 67.1Mb). Among these novel signals, we found associations unique to Hispanic Americans, including rs28364240, a missense variant for AA that is common in CHARGE Hispanic Americans but absent in other race/ancestry groups. Our study sheds light on the genetics of PUFAs and the value of investigating complex trait genetics across diverse ancestry populations. - Source: PubMed
Publication date: 2023/02/24
Yang ChaojieVeenstra JennaBartz TraciPahl MatthewHallmark BrianChen Yii-Der IdaWestra JasonSteffen LynBrown ChristopherSiscovick DavidTsai MichaelWood AlexisRich StephenSmith CarenO'Connor TimothyMozaffarian DariushGrant StruanChilton FloydTintle NathanLemaitre RozennManichaikul Ani - Tripartite motif containing 46 was initially identified as the oncogene in several human tumors. However, the clinical value and potential functions of tripartite motif containing 46 (TRIM46) in clear cell renal cell carcinoma (ccRCC) remained largely unclear. The expressing patterns, clinical involvement, and prognostic values of TRIM46 were analyzed using the data obtained from TCGA and GEO databases. A nomogram was constructed to examine the outcome of patients with ccRCC. We estimated the association between TRIM46 with tumor immunity in ccRCC. Tripartite motif containing 46 was highly expressed in ccRCC, and its upregulation revealed an unfavorable prognosis. A nomogram based on TRIM46 expressions and other independent prognostic factors could robustly predict the overall survival of tumor patients. TRIM46 has a strong positive correlation with NUMBL, CACNB1, THBS3, ROBO3, MAP3K12, ANKRD13D, PIF1, PRELID3A, ANKRD13B, and PCNX2. Mechanically, TRIM46 displayed regulatory functions in ccRCC progression several tumor-associated pathways. Besides, we observed that TRIM46 was distinctly related to tumor immunity in ccRCC. Our findings provide a novel tumor promotive role regarding TRIM46 function in the malignant progression of ccRCC. - Source: PubMed
Publication date: 2021/11/22
Ren Xiang-BinZhao JingLiang Xue-FengGuo Xu-DongJiang Shao-BoXiang Yu-Zhu