Ask about this productRelated genes to: FLYWCH1 Blocking Peptide
- Gene:
- FLYWCH1 NIH gene
- Name:
- FLYWCH-type zinc finger 1
- Previous symbol:
- -
- Synonyms:
- DKFZp761A132
- Chromosome:
- 16p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 2005-02-08
- Date modifiied:
- 2013-01-10
Related products to: FLYWCH1 Blocking Peptide
Related articles to: FLYWCH1 Blocking Peptide
- To systematically evaluate the contributions of parental and fetal genetic factors in recurrent spontaneous abortion (RSA) through trio-based exome sequencing and transmission disequilibrium test (TDT). We conducted whole-exome sequencing on 31 trios (mother, father, and miscarried fetus) affected by RSA, collected from Nanjing Drum Tower Hospital between March 2021 and December 2023. Using TDT, we analyzed common genetic variants to identify associations with RSA and performed parent-of-origin analysis to assess the independent contributions of paternal and maternal alleles. Rare variant TDT analysis was also conducted to identify associations at the gene level. Significant findings underwent computational validation (population genetics, functional prediction, gene constraint and mouse phenotypes). We identified one common variant (rs2034910825 in the DNA repair gene LIG1) and 15 suggestive SNPs associated with RSA. Computational validation showed 14/17 top SNPs enriched in East Asians. Functional predictions indicated potential deleterious effects or regulatory impacts for several variants, and mouse knockout models supported embryonic developmental roles for key genes (e.g., Lig1, Lrp2, and Flywch1). Additionally, our analysis revealed a paternal transmission bias at two loci (PRAMEF4 and SLC24A4), where alleles from fathers were preferentially transmitted to affected pregnancies. Gene-level rare variant analysis further implicated eight genes (PSG1, D2HGDH, OAS2, etc.) in placental development, angiogenesis, and DNA repair. This study reveals paternal genetic contributions and fetal-placental dysfunction pathways in RSA. Trio exome sequencing coupled with TDT provides a robust framework for unmasking familial transmission patterns, offering actionable markers for early risk prediction and personalized counseling. - Source: PubMed
Duan HongleiZhang JianJiang ZihanJia JiaLi JieDu Jing - Platinum-based combination chemotherapy remains the backbone of first-line treatment for patients with advanced epithelial ovarian cancer (EOC). While most patients initially respond well to the treatment, patients with relapse ultimately develop platinum resistance. This study identified FLYWCH-type zinc finger-containing protein 1 (FLYWCH1) as an important regulator in the resistance development process. We showed that the loss of FLYWCH1 promotes platinum resistance in EOC cells, and the low FLYWCH1 expression is correlated with poor prognosis of EOC patients. In platinum-sensitive cells, FLYWCH1 colocalizes with H3K9me3, but this association is significantly reduced when cells acquire resistance. The suppression of FLYWCH1 induces gene expression changes resulting in the deregulation of pathways associated with resistance. In line with its connection to H3K9me3, FLYWCH1 induces gene silencing in a synthetic reporter assay and the suppression of FLYWCH1 alters H3K9me3 at promoter regions and repeat elements. The loss of FLYWCH1 leads to the derepression of LTR and Alu repeats, thereby increasing transcriptional plasticity and driving the resistance development process. Our data highlight the importance of FLYWCH1 in chromatin biology and acquisition of platinum resistance through transcriptional plasticity and propose FLYWCH1 as a potential biomarker for predicting treatment responses in EOC patients. - Source: PubMed
Publication date: 2025/04/04
Fullstone Tabea LRohm HeleneKaltofen TillHierlmayer SophiaReichenbach JulianeSchweikert SimonKnodel FranziskaLoeffler Ann-KathrinMayr DorisJeschke UdoMahner SvenKessler MirjanaTrillsch FabianRathert Philipp - Lung cancer is a primary global health concern, responsible for a considerable portion of cancer-related fatalities worldwide. Understanding its molecular complexities is crucial for identifying potential targets for treatment. The goal is to slow disease progression and intervene early to prevent the development of advanced lung cancer cases. Hence, there's an urgent need for new biomarkers that can detect lung cancer in its early stages. - Source: PubMed
Publication date: 2025/02/10
Shah Syed Naseer AhmadParveen Rafat - - Source: PubMed
Publication date: 2024/10/30
Almozyan SheemaBabaei-Jadidi RoyaAljohani AbrarYoussefi SepidehDalleywater WilliamKadam PrernaSpencer-Dene BradleyRakha EmadIlyas MohammadShams Nateri Abdolrahman - Nonalcoholic fatty liver disease (NAFLD) is considered the most prevalent chronic liver disease, but the understanding of the mechanism of NAFLD is still limited. The aim of our study was to explore hub lncRNAs and mRNAs and pathological processes in high-fat diet (HFD)-induced and lycopene-intervened liver steatosis. We analyzed the gene profiles in the GSE146627 dataset from the Gene Expression Omnibus (GEO) database to identify differentially expressed lncRNAs and mRNAs, and we constructed coexpression networks based on weighted gene coexpression network analysis (WGCNA). The Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) databases were utilized for functional enrichment analysis. We found that the turquoise, blue, brown, yellow, green, and black modules were significantly correlated with NAFLD. Functional enrichment analysis revealed that some hub lncRNAs (Smarca2, Tacc1, Flywch1, and Mef2c) might be involved in the regulation of the inflammatory and metabolic pathways (such as TNF signaling, metabolic, mTOR signaling, MAPK signaling, and p53 signaling pathways) in NAFLD. The establishment of an NAFLD mouse model confirmed that lycopene supply attenuated hepatic steatosis in HFD-induced NAFLD. Our analysis revealed that the inflammatory and metabolic pathways may be crucially involved in the pathogenesis of NAFLD, and hub lncRNAs provide novel biomarkers, therapeutic ideas, and targets for NAFLD. Moreover, lycopene has the potential to be a phytochemical for the prevention of HFD-induced liver steatosis. - Source: PubMed
Publication date: 2023/02/14
Sui JingPan DaYu JunhuiWang YingSun GuijuXia Hui