GPR177 Blocking Peptide
- Known as:
- GPR177 Blocking Peptide
- Catalog number:
- 33r-1477
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Fitzgerald industries international
- Gene target:
- GPR177 Blocking Peptide
Related genes to: GPR177 Blocking Peptide
- Gene:
- WLS NIH gene
- Name:
- Wnt ligand secretion mediator
- Previous symbol:
- C1orf139, GPR177
- Synonyms:
- FLJ23091, MRP, wls, EVI, mig-14
- Chromosome:
- 1p31.3
- Locus Type:
- gene with protein product
- Date approved:
- 2005-07-08
- Date modifiied:
- 2018-11-09
Related products to: GPR177 Blocking Peptide
Related articles to: GPR177 Blocking Peptide
- Weight-loss surgery (WLS) remains the most effective treatment for clinically severe obesity, while weight-loss medications (WLM), particularly GLP-1 agonists, have recently gained widespread public attention. With YouTube serving as a major source of health information, the quality and tone of videos discussing these interventions warrant evaluation. This study compares the source, content quality, and perceived tone of YouTube videos related to WLS and WLM. - Source: PubMed
Publication date: 2026/04/13
Botvinov JuliaHenrich MasonDeng QichenJawed AramMerchant Aziz M - : Cardiac allograft fibrosis is an important limiting factor for long-term graft survival. However, the fibrotic process operating in patients with acute cellular rejection (ACR) remains unclear. We aimed to identify altered serum mRNAs related to cardiac fibrosis in patients with ACR and to evaluate their diagnostic accuracy in detecting rejection episodes. : We included 40 serum samples from recipients of transplants undergoing routine endomyocardial biopsies. : Several altered mRNAs associated with fibrosis were detected in patients with ACR. Specifically, the activators of fibroblasts and myofibroblasts (, and ), TGF-β signaling ( and ) and WNT signaling ( and ) pathways were significantly different when we compared grade ≥ 2R ACR and/or grade 1R ACR groups with the nonrejection group. Furthermore, and presented an area under the curve value > 0.90 for identifying patients with moderate and severe grades of cardiac rejection. : In conclusion, we found alterations in the relative abundance of circulating activators of fibroblasts and myofibroblasts, such as or , as well as in major profibrotic pathways, including TGF-β and WNT signaling, especially in clinically relevant cardiac rejection. These findings may contribute to improving the surveillance of patients with cardiac transplant and provide new therapeutic strategies for targeting fibrosis process activation. - Source: PubMed
Publication date: 2026/06/18
Delgado-Arija MartaPérez-Carrillo LorenaGonzález-Torrent IreneGenovés PatriciaGiménez-Escamilla IsaacBenedicto CarlotaMartínez-Dolz LuisPortolés ManuelTarazón EstefaníaRoselló-Lletí Esther - Wnt proteins are lipid-modified morphogens fundamental in development and disease. During Wnt biogenesis, the G-protein-coupled receptor (GPCR)-like transporter Wntless (WLS) escorts lipidated Wnts from the endoplasmic reticulum to the plasma membrane, then transfers them to extracellular carriers, forming active and soluble morphogen-carrier complexes. To dissect the mechanisms involved, we solve cryo-EM structures of Wnt-bound WLS and unliganded WLS, and perform structure-guided functional experiments. Wnts engage WLS via three conserved hairpins, which are all required for Wnt trafficking to the cell surface and carrier-mediated secretion. Wnt release from cells is driven by dramatic conformational changes in the WLS transmembrane domain, reminiscent of GPCR activation, together with WLS extracellular rearrangements. Unexpectedly, we find that Wnt5a bound to WLS forms dimers, with implications for Wnt signaling. These findings define the mechanism of WLS conformational cycling that governs the intracellular transport and extracellular release of Wnt morphogens, essential steps in the Wnt pathway. - Source: PubMed
Publication date: 2026/06/19
Ge Yunhuide Almeida Magalhaes TacianiWu Hongjiangvan den Boomen Dick J HNguyen Thu UyenDou TongyiYadav Gaya PLee SukyeongWang ZhaoLemoff AndrewLuo XuemeiMenon Sumitha SZhang MinWang JinJin ZhichengJiang JiansenSalic AdrianHuang Pengxiang - To establish an objective discard framework for lead aprons, defect areas quantified from X-ray fluoroscopy videos were linked to their corresponding dosimetric impacts. A fine-tuned YOLOv8 instance segmentation model, achieving an average precision at an intersection-over-union threshold of 0.5 (AP@0.5) of 0.457, was employed to analyze fluoroscopic videos of 18 aprons with 0.25 mmPb equivalence. The model enabled automated defect detection and area estimation with a video processing time of 15 s. Dosimetry experiments mimicking endoscopic retrograde cholangiopancreatography (ERCP) conditions were conducted using an anthropomorphic phantom and apron samples with slit defects of varying widths. The results indicated that the transmitted dose increased linearly with defect area under all tested conditions. Based on weighted least-squares analysis of covariance (WLS-ANCOVA), slit widths of 1.0, 2.0, and 3.5 mm were pooled for modeling, as they exhibited similar dosimetric behavior. A linear model was applied to relate defect area to the increase in transmitted dose, defining the discard threshold as the minimum area at which the upper one-sided 95% prediction limit reached a specified dose limit. Given a baseline dose of 2.38 mSv after transmission through the apron without defects and a regulatory dose limit of 5 mSv per 3 months, the discard threshold for slit-like defects was determined to be 2.87 cm. The proposed framework enables automated and facility-tailorable discard decisions by linking quantified defects to radiation protection objectives using conservative, prediction-based criteria. - Source: PubMed
Publication date: 2026/06/19
Hanada KoichiSuzuki HarukaTakahashi MasatoFuse HirakuKimura ManamuSasaki KotaYasue KenjiNosaka HirokiMiyakawa ShinKoori Norikazu - To support regulatory clearance decisions for liquid radioactive waste (LRW) under in-situ constraints, ambient dose equivalent assessment must be reliable with limited acquisition time while minimizing occupational exposure. This study proposes a Bayesian Weighted Least Squares (B-WLS) framework to derive a spectrum-to-dose conversion operator, G(E), that infers H(10) directly from short-count gamma-ray spectra. A 1-inch LaBr(Ce) scintillation detector was implemented, and a detector response matrix was constructed using an MCNP6 model calibrated with Gaussian energy broadening to match measured resolution. The G(E) function was parameterized as a polynomial in log(E) and its coefficients were estimated using three approaches: least squares method (LSM), adaptive moment estimation (Adam) optimizer, and the proposed B-WLS method with heteroscedastic weighting and Bayesian regularization. The performance was validated using Cs and Co spectra acquired at multiple dose rate levels and compared against theoretical dose rates. A model-order sensitivity analysis identified distinct optimal polynomial orders, with B-WLS achieving the lowest mean absolute percentage error (MAPE) of 1.17% among the evaluated methods. Across dose rate conditions, B-WLS showed the most consistent linearity and reduced sensitivity to low-count fluctuations, providing stable inference in low-dose regimes where the deterministic methods are more vulnerable to channel-level statistical variability. These results indicate that Bayesian regression with heteroscedastic weighting offers an operationally robust option for field-deployable G(E)-based dose rate screening of LRW, supporting conservative decision-making in radiation protection. - Source: PubMed
Publication date: 2026/06/03
Park JaehyunSong GyohyeokKim JisooCho Gyuseong