Ask about this productRelated genes to: HSPB6 Blocking Peptide
- Gene:
- HSPB6 NIH gene
- Name:
- heat shock protein family B (small) member 6
- Previous symbol:
- -
- Synonyms:
- FLJ32389, Hsp20, PPP1R91
- Chromosome:
- 19q13.12
- Locus Type:
- gene with protein product
- Date approved:
- 2004-05-12
- Date modifiied:
- 2016-10-05
Related products to: HSPB6 Blocking Peptide
Related articles to: HSPB6 Blocking Peptide
- Bladder cancer (BC) is a prevalent malignant tumor worldwide, posing a significant public health burden and challenge to human society. Current therapeutic modalities for BC include surgical treatment, radiotherapy, chemotherapy, targeted therapy, and immunosuppressive therapy. However, almost all patients experience disease progression and ultimately succumb to BC. Our study demonstrated that elevated expression of Heat Shock Protein Beta-6 (HSPB6) correlated with higher clinical grades and stages, establishing it as an independent prognostic risk factor for BC. Enrichment analysis indicated that HSPB6 is associated with the extracellular matrix in BC. Experimental validation revealed that HSPB6 overexpression inhibits the proliferation of BC cell line T24. This effect may be achieved by inhibiting the PI3K/Akt signaling pathway, which in turn leads to inhibition of epithelial-mesenchymal transition (EMT). Furthermore, we developed a prognostic risk model that incorporated DDR2, DPYSL3, MFAP5, PDGFRB, and SPOCD1, allowing accurate prediction of patient outcomes based on immunological status. In conclusion, this study highlights that HSPB6 overexpression can restrain the proliferation of BC cells and inhibit EMT, underscoring its potential as a diagnostic marker and therapeutic target in BC. - Source: PubMed
Publication date: 2026/04/20
Wang Jian-SheQiu Yi-FanZhang LuJi BoLiang SenWang Ya-XuanZhu Hai-Xia - BackgroundThe cellular mechanisms that promote the maintenance of cognitive abilities in very old people designated as successful agers remain under-investigated. Here, we report an episodic memory performance-based criteria that differentiates superior cognitive function from normative cognitive function in adults aged 80 and older.ObjectiveUsing this new criteria, we demonstrate how neuropathological and neurobiological underpinnings of superior cognitive performance can be investigated.MethodsThe most recent verbal episodic memory WMS-R Logical Memory Delayed Recall (LM-DR) score was derived from 144 participants with no cognitive impairment (NCI) 80 years or older participants from the Rush Religious Orders Study classified with Superior Cognitive Performance (SCP, LM-DR ≥ 14) or Normal Cognitive Performance (NCP, LM-DR 13 ≥ 7). Both groups were compared on neuropathological measures for neuritic plaque (NP), diffuse plaque (DP), and neurofibrillary tangle (NFT) load.ResultsNP (p = 0.44), DP (p = 0.27), and NFT (p = 0.28) burden did not differ between SCP and NCP cases. LM-DR scores did not correlate with NP (r = -0.08, p = 0.32), DP (r = -0.14, p = 0.07), or NFT (r = -0.12, p = 0.13) load. Biochemical analysis revealed significantly higher levels of heat-shock protein HSPB6 in SCP compared to NCP (p < 0.001).ConclusionsHeat shock protein differences were observed between NCP and SCP groups. This suggests that our proposed criteria for SCP can help identify neurobiological mechanisms of successful cognitive aging. Our SCP criteria are also concordant with the SuperAger criteria which supports the generalizability of the SCP criteria to other datasets. - Source: PubMed
Publication date: 2026/04/20
Malek-Ahmadi MichaelPerez Sylvia EHe BinRogalski EmilyCounts Scott EIkonomovic Milos DAbrahamson Eric EGinsberg Stephen DAlldred Melissa JSerrano Geidy EBelden Christine MAtri AlirezaMufson Elliott J - Esophageal squamous cell carcinoma (ESCA) is one of the most common cancers worldwide. PANoptosis is an inflammatory programmed cell death pathway event regulated by the PANoptosome complex. Currently, there is limited research on the PANoptosis-related genes (PORGs) in ESCA. We aim to explore the prognostic biomarkers of PANoptosis in ESCA and their underlying mechanisms through comprehensive bioinformatics analysis. - Source: PubMed
Publication date: 2026/03/18
Jie RundaLiu YiningWang TianbiaoWusiman ShabahaitiRen HongdaTuoheniyazi WugelinisanLiu Ling - Filamin C is an adapter protein involved in the regulation of cytoskeleton; it interacts with more than 90 protein partners, including small heat shock proteins (sHsps). However, the details of filamin C interaction with sHsps remain poorly characterized. Here, we used immunochemistry methods, size-exclusion chromatography, native gel electrophoresis, and chemical crosslinking to investigate the interactions of a long C-terminal fragment of filamin C containing immunoglobulin (Ig)-like domains 19-24 (FLNC19-24) with sHsps. Out of five analyzed sHsps (HspB1, phosphorylation-mimicking 3D mutant of HspB1, HspB5, HspB6, HspB7, and HspB8), only HspB7 formed complexes with FLNC19-24. Taking into account that HspB7 interacted with the isolated Ig-like domain 24 and filamin fragments containing Ig-like domains 22-24 and 19-24, we concluded that HspB7 is a bona fide partner of filamin C. Selective binding of the α-crystallin domain of HspB7 with the Ig-like domain 24 induced dissociation of filamin dimers, which might promote filamin C translocation in the cell and facilitate the repairs of damaged contractile apparatus. - Source: PubMed
Zamotina Maria AMuranova Lidia KTyurin-Kuzmin Pyotr ASluchanko Nikolai NGusev Nikolai B - Compared to other amphibians, the Xizang plateau frog, , is the highest elevation-dwelling amphibian species known to date (up to 5,100 m), offering a valuable model for understanding ectotherm adaptation to extreme environments. Here, we compared plasma metabolomes and lung transcriptomes of frogs between higher (4,600 m) and lower (3,400 m) elevations. We also assayed key metabolites (glucose, lactate, NADH, β-hydroxybutyrate) in the plasma and inferred the metabolic flux of central metabolic pathways. - Source: PubMed
Publication date: 2026/01/20
Zhang XuejingNiu YonggangMen ShengkangChen QiangTang Xiaolong