Ask about this productRelated genes to: ERAS Blocking Peptide
- Gene:
- ERAS NIH gene
- Name:
- ES cell expressed Ras
- Previous symbol:
- HRAS2, HRASP
- Synonyms:
- -
- Chromosome:
- Xp11.23
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2015-08-25
Related products to: ERAS Blocking Peptide
Related articles to: ERAS Blocking Peptide
- Background Early mobilisation is a key component of Enhanced Recovery After Surgery (ERAS) protocols and has been associated with improved postoperative recovery following major spine surgery. However, limited prospective data exist regarding the impact of the interval between extubation and first mobilisation on postoperative outcomes. Objective This study aims to prospectively evaluate the extubation-to-first mobilisation interval in patients undergoing major spine surgery and assess its association with postoperative pain, analgesic requirements, complications, and hospital stay. Methods This prospective observational study was conducted at Stavya Spine Hospital and Research Institute, Ahmedabad. Adult patients undergoing planned major spine surgery, including multilevel fusion, instrumentation, and complex decompression procedures, were consecutively enrolled. The primary variable assessed was the interval (hours) between extubation and first out-of-bed mobilisation. Postoperative outcomes included serial Visual Analog Scale (VAS) pain scores, analgesic requirements, Oswestry Disability Index (ODI), complications, and duration of hospital stay. Results A total of 267 patients were included. The mean extubation-to-first mobilisation interval was 14.9 ± 9.3 hours. Among patients with documented mobilisation timing, 102 patients were mobilised within 6 hours, 96 within 24 hours, and 2 beyond 24 hours post-extubation. Earlier mobilisation was associated with lower postoperative pain scores. Patients mobilised within 6 hours demonstrated lower mean VAS scores at 6, 24, 48, and 72 hours compared to those mobilised at 24 hours. The mean discharge VAS and ODI scores were 3.0 and 18.2, respectively, with an average hospital stay of 4.3 ± 1.6 days. Higher analgesic requirements, including tramadol-containing combinations and rescue Butrum analgesia, were associated with relatively higher pain scores and delayed mobilisation. Earlier mobilisation was more commonly observed following minimally invasive lumbar procedures, whereas delayed mobilisation was associated with multilevel fusion procedures, greater blood loss, and longer operative duration. Conclusion The extubation-to-first mobilisation interval appears to be a simple and clinically meaningful parameter reflecting early postoperative recovery following major spine surgery. Earlier mobilisation was associated with lower postoperative pain scores and favourable recovery trends. Larger prospective multicentre studies with adjustment for potential confounders are required to determine whether earlier mobilisation independently influences postoperative outcomes. - Source: PubMed
Publication date: 2026/08/13
Dave Bharatkumar RKulkarni Saurabh SMayi Shivanand CKrishnan AjayRai Ravi RanjanDave Mirant BPanthackel MikesonVashishtha ArjitAdodariya YogenkumarShahade Rushikesh BPanjwani Kishan - Delayed graft function (DGF) is common after simultaneous heart-kidney (SHK) transplantation, yet its predictors and long-term consequences in contemporary practice remain incompletely defined. We evaluated the incidence, determinants, and impact of DGF on kidney graft outcomes in a national SHK cohort. - Source: PubMed
Zahran SomayaZemla TylerSmith ByronRosenbaum AndrewIssa Naim SAmer HatemBentall Andrew JCortez Alexander RRiad Samy M - The core clinical decision in geriatric femoral neck fracture-internal fixation vs. arthroplasty-has remained contested for half a century. Although landmark trials such as FAITH, HEALTH, and WHiTE 5 have profoundly reshaped clinical practice, no bibliometric study has systematically mapped the complete research architecture and knowledge evolution trajectory of this field from 1975 to the present. This study aimed to characterize the global research landscape and knowledge evolution of surgical treatment for geriatric femoral neck fracture using a tri-tool framework integrating CiteSpace, VOSviewer, and Bibliometrix with dual-database validation (WoSCC + Scopus). - Source: PubMed
Publication date: 2026/08/28
Zhang Da-WeiHong Hai-TingLin Liang-HeFu Zhen-Xin - Postoperative complications and readmissions remain common after cardiac surgery, and intermittent manual vital-sign checks leave patients unmonitored for much of the recovery period. We implemented a phygital care pathway combining Enhanced Recovery After Surgery (ERAS) protocols, and 21-day continuous remote monitoring (heart rate, respiratory rate, temperature, blood pressure, oxygen saturation) with daily review and escalation to a cardiac surgeon when indicated. Quality of Recovery (QoR-15) was assessed on preoperative days -1 and postoperative days 3 and 7, and patient-reported experience (PREM) on day 30. Outcomes in 221 monitored patients (May-November 2025) were compared, retrospectively, with a historical, non-monitored cohort of 206 patients. In the monitored patients, a good-to-excellent QoR increase from 25% to 56% between days 3 and 7 was noticed. Seventy-five patients (34%) required 98 interventions, most commonly primary-care referral or medication adjustment. Thirty-day readmission (12.7% vs 12.1%, Fisher p = 0.88) and mortality (0.45% vs 1.4%, Fisher p = 0.36) did not differ significantly from the control cohort; the monitored group was significantly younger (66.7 vs 70.1 years, p = 0.0004), reflecting probable selection bias from smartphone and digital-literacy eligibility criteria. PREM scores were high (>91%). This pilot demonstrates the feasibility of a digital, patient-centered cardiac surgical pathway; readmission and mortality findings are hypothesis-generating and require prospective confirmation. - Source: PubMed
Publication date: 2026/09/11
Stevens GuylianFleerakkers JelleFrançois JulesBallaux PhillipeCathenis KoenVerdonck Pascal - The treatment paradigm for patients with human epidermal growth factor receptor 2 (HER2)-negative advanced gastric cancer (aGC) has shifted after the introduction of new regimens. - Source: PubMed
Publication date: 2026/09/11
Hironaka ShuichiKimijima YuyaShinno YusukeNishiyama EijiKikko YorifumiMatsuda YukoYamamoto TsunehisaTeixeira Bruno CasaesYoshikawa Takaki