Ask about this productRelated genes to: DPY19L4 Blocking Peptide
- Gene:
- DPY19L4 NIH gene
- Name:
- dpy-19 like 4
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 8q22.1
- Locus Type:
- gene with protein product
- Date approved:
- 2005-07-19
- Date modifiied:
- 2017-08-04
Related products to: DPY19L4 Blocking Peptide
Related articles to: DPY19L4 Blocking Peptide
- Stroke is a serious disease, ranking among the leading causes of mortality and permanent disability in EU countries. The ischemic cascade, triggered by the blockage of oxygenated blood supply to brain tissue, leads to excitotoxicity, oxidative stress, inflammation, and eventually, cell death. Current research highlights the promising neuroprotective effects of conditioning, which induces ischemic tolerance (IT). Thus, the main objective of this study is to analyze selected genes affected by ischemic stroke and the neuroprotective response to ischemic stroke, with a focus on ischemia and ischemic tolerance in peripheral blood. We investigated changes in gene expression indicative of cerebral ischemia during carotid endarterectomy (CEA), a procedure that involves the temporary occlusion of the . To assess the influence of CEA on IT induction, we performed a whole-transcriptome analysis of peripheral blood cells isolated from symptomatic (791 DEGs in correlation with negative control), asymptomatic (688 DEGs in correlation with negative control), and oximetric (637 DEGs in correlation with negative control) patients. The presence of gene expression changes in genes selectively identified through whole-transcriptome analysis was subsequently statistically verified. Using quantitative qRT-PCR, we monitored gene expression changes in10 genes and . The results suggest that CEA affected the expression of all monitored genes, with statistically significant differences between groups, indicating the activation of distinct ischemic tolerance cascades in different patient groups. These findings may contribute to a better understanding and characterizing of the molecular mechanisms underlying ischemic tolerance. - Source: PubMed
Publication date: 2026/02/03
Mucha RastislavFurman MarekUrbanova AlexandraKopolovets IvanNemethova MiroslavaVirag MichalHresko StanislavKatuch VladimirSihotsky Vladimir - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (CESC) is a highly prevalent female malignancy. As the epigenomic characteristics of immune cells and cancer cells can serve as predictive indicators for the response to cancer immunotherapy, analysis of epigenetically modified genes (EpiGenes) could contribute to CESC treatment. - Source: PubMed
Zhang HuizhenLi JunjieXu HengZhang ShiSongLu YunkunFeng Sijie - Thrombospondin type 1 repeats (TSRs) occur in diverse proteins involved in adhesion and signaling. The two extracellular TSRs of the netrin receptor UNC5A contain WxxWxxWxxC motifs that can be mannosylated on all tryptophans. A single -mannosyltransferase (dumpy-19, DPY-19), modifying the first two tryptophans, occurs in , but four putative enzymes (DPY-19-like 1-4, DPY19L1-4) exist in mammals. Single and triple CRISPR-Cas9 knockouts of the three homologs that are expressed in Chinese hamster ovary cells (DPY19L1, DPY19L3, and DPY19L4) and complementation experiments with mouse homologs showed that DPY19L1 preferentially mannosylates the first two tryptophans and DPY19L3 prefers the third, whereas DPY19L4 has no function in TSR glycosylation. Mannosylation by DPY19L1 but not DPY19L3 is required for transport of UNC5A from the endoplasmic reticulum to the cell surface. In vertebrates, a new -mannosyltransferase has apparently evolved to increase glycosylation of TSRs, potentially to increase the stability of the structurally essential tryptophan ladder or to provide additional adhesion functions. - Source: PubMed
Publication date: 2017/02/15
Shcherbakova AleksandraTiemann BirgitBuettner Falk F RBakker Hans