Ask about this productRelated genes to: SRPRB Blocking Peptide
- Gene:
- SRPRB NIH gene
- Name:
- SRP receptor subunit beta
- Previous symbol:
- -
- Synonyms:
- APMCF1, SR-beta
- Chromosome:
- 3q22.1
- Locus Type:
- gene with protein product
- Date approved:
- 2004-01-29
- Date modifiied:
- 2018-04-23
Related products to: SRPRB Blocking Peptide
Related articles to: SRPRB Blocking Peptide
- Breast cancer is the leading cause of cancer-related deaths in women worldwide, and triple-negative breast cancer (TNBC), accounting for 15-20% of all breast cancer cases, has the poorest prognosis among all subtypes. As a component of the signal recognition particle (SRP) receptor (SR) complex, SRPRB is involved in tumorigenesis and progression, yet its specific regulatory mechanism in TNBC remains to be elucidated. - Source: PubMed
Publication date: 2026/03/22
Liu HuanHuo Yi-XuanRao YingWang Shu-HanLiu Yi-XinWei Wan-ShuoLu Guan-MingJiang Li-He - Ischemic stroke (IS) remains a leading cause of death and disability, with limited effective treatments in the acute phase. Mitophagy, the selective degradation of damaged mitochondria, plays a crucial role in cellular homeostasis and survival during IS. However, its exact mechanisms in stroke pathophysiology remain unclear. This study utilized a multi-omics approach, integrating gene expression data from bulk and single-cell RNA sequencing, to investigate the role of mitophagy-related genes (MRGs) in IS. We identified differentially expressed MRGs (DE-MRGs) in IS using bioinformatics techniques, including weighted gene co-expression network analysis (WGCNA) and machine learning models, which led to the identification of five core biomarkers: SRPRB, ATP5J, LSM7, DEGS1, and TGDS. Validation via qPCR and analysis of immune cell infiltration further supported their relevance. Single-cell analysis revealed significant differences in mitophagy activity in microglial subpopulations, with ATP5J showing dynamic expression patterns linked to stroke-induced mitochondrial dysfunction. Additionally, pseudo-time analysis suggested a progressive shift from homeostatic to disease-associated microglial states. Our findings highlight the complexity of mitophagy regulation in IS and suggest that targeting mitophagy-related pathways, such as ATP5J, could provide novel therapeutic strategies for IS management. - Source: PubMed
Publication date: 2026/03/06
Cao ZhanWang YingluanSun MingjianDu RunyiFeng XuWang LinZhao ZiyiSun Wei - Heart failure is a major cause of global morbidity and mortality, often complicated by ventricular arrhythmias (VAs) that worsen prognosis. The (signal recognition particle receptor beta subunit) is an endoplasmic reticulum membrane-anchored protein involved in protein processing. - Source: PubMed
Publication date: 2026/01/22
Zhang JingjingPan YuchengGong YangKong BinChen TaoShuai WeiHuang He - Endometrial receptivity is essential for successful pregnancy, and endometriosis is widely recognized as a disruptor of this process. Poor endometrial receptivity is also a key factor contributing to recurrent implantation failure. Although some molecular mechanisms related to endometrial receptivity have been identified, their specific roles in endometriosis and recurrent implantation failure remain unclear. This study aimed to elucidate the shared molecular mechanisms affecting endometrial receptivity in endometriosis and recurrent implantation failure using multi-omics data analysis. We sourced datasets from the NCBI GEO database and employed weighted gene co-expression network analysis to identify gene modules associated with these conditions, followed by gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses. Single-cell sequencing analysis and immunofluorescence were used for expression analysis. We identified 3690 and 4892 upregulated genes and 2675 and 5065 downregulated genes in endometriosis and recurrent implantation failure, respectively. Functional enrichment analysis and validation identified 15 hub genes including SRPRB, SLC35B1, and SLC25A6. Receiver operating characteristic curve analysis demonstrated that these genes are associated with high diagnostic accuracy. Single-cell sequencing analysis indicated that these genes are predominantly expressed in basal epithelial cells, with RBM3 being particularly prominent. This study provides new insights into the molecular mechanisms underlying endometrial receptivity and identifies potential targets for the diagnosis and treatment of endometriosis and recurrent implantation failure. - Source: PubMed
Publication date: 2025/12/29
Yu JieWang WeiLi QiongLan LanJiang Li-LiHe Xin-RongJiang Xiao-WeiYan Yu-LinYao Xiao-MingWang Meng-YueDuan Ping-MeiHuang Lin-ChunQi Hai-FengYu Ting-He - To screen differentially expressed genes (DEGs) in triple-negative breast cancer (TNBC) by bioinformatic methods and explore their relationship between TNBC prognosis and related biological functions. - Source: PubMed
Liu YaruiZeng Ying