Ask about this productRelated genes to: FOXM1 Blocking Peptide
- Gene:
- FOXM1 NIH gene
- Name:
- forkhead box M1
- Previous symbol:
- FKHL16
- Synonyms:
- HFH-11, trident, HNF-3, INS-1, MPP2, MPHOSPH2, TGT3
- Chromosome:
- 12p13.33
- Locus Type:
- gene with protein product
- Date approved:
- 1997-07-25
- Date modifiied:
- 2016-10-05
Related products to: FOXM1 Blocking Peptide
Related articles to: FOXM1 Blocking Peptide
- Clear cell renal cell carcinoma (ccRCC) is the most common renal carcinoma subtype. Aging-related genes (ARGs) are implicated in ccRCC progression, though their mechanisms remain unclear. This study aimed to elucidate the molecular mechanisms of ARGs in ccRCC and identify potential prognostic biomarkers and therapeutic targets. Transcriptomic data from the cancer genome atlas (TCGA-ccRCC) cohort were analyzed. differentially expressed genes and ARGs were intersected to identify candidate genes. Prognostic ARGs were then screened using machine learning algorithms. A risk model was constructed and validated through survival analysis, stratifying patients into high- and low-risk groups. Functional enrichment, immune infiltration, and drug prediction analyses were performed. The expression levels of prognostic genes in ccRCC tissues were validated through reverse transcription quantitative polymerase chain reaction (RT-qPCR). A total of 2312 differentially expressed genes and 307 ARGs were identified, of which 25 overlapping genes were selected as candidates. Seven ARGs were significantly associated with patient prognosis: protective PCK1, and risk-related TOP2A, TFAP2A, CCNA2, FOXM1, CDKN2A, and PLAU. High-risk patients showed reduced overall survival rates. Immune infiltration and checkpoint expression differed significantly between risk groups. decision curve analysis indicated high clinical utility. Drug prediction identified 69 potential therapeutic compounds, including tyrosine kinase and mTOR inhibitors. RT-qPCR validated 5 genes' expression, consistent with bioinformatics predictions, though discrepancies were observed in the expression patterns of FOXM1 and CDKN2A. Seven ARGs were identified as key prognostic markers in ccRCC. A robust risk model was established, providing insights into ARG-related mechanisms and potential diagnostic and therapeutic strategies. - Source: PubMed
Liu ChenShuang WeibingCao XiaomingGao Ying - Endometrial cancer(EC) is increasing worldwide, but its molecular mechanisms remain unclear. This study explored whether RBM15B-mediated m6A modification of FOXM1 promotes EC progression through the AURKA/TPX2 axis and epithelial-mesenchymal transition(EMT). Bioinformatics analyses assessed FOXM1 expression and prognosis in EC. RNA pull-down, MeRIP-PCR, dot blot, and RNA stability assays examined m6A regulation. Colony formation, Transwell, wound healing, and tumor sphere assays evaluated malignant behaviors. FOXM1 was significantly upregulated in EC and associated with unfavorable prognosis. Functional assays showed that FOXM1 enhanced proliferation, migration, invasion, and stemness of EC cells. Mechanistically, RBM15B increased m6A modification of FOXM1 mRNA and promoted expression. RBM15B knockdown inhibited malignant phenotypes and reduced activation of the downstream AURKA/TPX2 pathway. RBM15B-mediated m6A methylation stabilizes FOXM1 expression, activates the AURKA/TPX2 axis, and promotes EMT and EC progression. Targeting the RBM15B/FOXM1/AURKA/TPX2 pathway may offer therapeutic potential. - Source: PubMed
Publication date: 2026/05/18
Zhang LijingWu Ping - The ATR-enforced S/G2 checkpoint activates during DNA replication to restrain CDK1-dependent phosphorylation of FOXM1 and subsequent transactivation of the G2/M gene network until the end of S phase. However, the extent to which this checkpoint ensures the completion of DNA replication and whether it safeguards genomic integrity has remained unknown. Here, we induce S/G2 checkpoint failure throughout S phase in non-malignant human epithelial cells using multiple ATR pathway inhibitors. Consequently, the mitotic kinase complex cyclin B1-CDK1 prematurely shuts-down the DNA replication program, preventing the completion of genome duplication. In turn, this leads to the retention of inactive replisomes on chromatin and unfired origins into the G2 phase, which induce subsequent accumulation of pan-nuclear ᵧH2AX and mitotic failure. Collectively, these findings indicate the S/G2 checkpoint ensures replication completion and genome stability. - Source: PubMed
Publication date: 2026/05/09
McEvoy Melissa JSaldivar Joshua C - It is well established that tumor-associated macrophages (TAMs) are crucial to the development of tumors. Here, we looked into how SHP2 and M2/M1 macrophages affected gastric cancer. - Source: PubMed
Publication date: 2026/04/30
Bai JingRen HuiZhang YachenLi Xiao - What is the role of FOXM1 in the pathogenesis of recurrent pregnancy loss (RPL) characterized by increased decidual senescence, and how do two progesterone analogues (medroxyprogesterone acetate [MPA] and dydrogesterone [DYD]) modulate FOXM1 expression and associated senescence markers in an in-vitro decidualization model? - Source: PubMed
Publication date: 2026/02/28
Kendirci-Katirci RemziyeKatirci ErtanSanhal Cem YKirtis EmineSati LeylaCelik-Ozenci Ciler