Ask about this productRelated genes to: ACAA2 Blocking Peptide
- Gene:
- ACAA2 NIH gene
- Name:
- acetyl-CoA acyltransferase 2
- Previous symbol:
- -
- Synonyms:
- DSAEC
- Chromosome:
- 18q21.1
- Locus Type:
- gene with protein product
- Date approved:
- 1999-09-28
- Date modifiied:
- 2016-10-05
Related products to: ACAA2 Blocking Peptide
Related articles to: ACAA2 Blocking Peptide
- Aberrant epithelial remodeling, driven by a shift from ciliated to goblet cell ratio, is central to chronic nasal inflammation. Despite the known role of metabolism in normal epithelial differentiation, the specific metabolic reprogramming patterns underlying this pathological shift of nasal epithelium induced by type 2 inflammatory milieu is poorly understood. This study aimed to delineate the key metabolic pathways involved in aberrant nasal epithelial differentiation. - Source: PubMed
Publication date: 2026/04/27
Lin YutongYe XiaoyanZhong YingqianLi LiyueHuang XianxiongChen HexinMeng QingxiangGao YifangLi JianHuang JianfengLi Chunwei - Adipose tissue functions not only as a primary energy reservoir but also as a metabolically active endocrine organ. However, the morphological and molecular differences among adipose depots from different anatomical sites in Yili horses remain unclear. This study aimed to compare the morphological characteristics and proteomic profiles of subcutaneous adipose tissue (SAT) and pericardial adipose tissue (PCAT). To this end, adipose tissue samples from 18 Yili horses were analyzed using hematoxylin and eosin (H&E) staining, while a subset of samples from 6 horses was subjected to proteomic analysis. The results demonstrated that adipocytes in PCAT showed significantly larger areas and diameters but a lower number per field than those in SAT ( < 0.01). Proteomic profiling identified 451 differentially expressed proteins (DEPs) between SAT and PCAT. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses indicated that these DEPs were primarily involved in fatty acid catabolism, glycolysis, ECM-receptor interaction, thermogenesis, Wnt signaling, and other related pathways. Notably, enrichment analyses further revealed that SAT exhibited more active substrate utilization, energy metabolism, and lipid turnover, whereas PCAT was more associated with structural regulation and cardiovascular-related signaling pathways. Furthermore, correlation analysis between adipocyte morphological metrics and proteomic data identified ACAA2, ENO1, TPI1, PLIN1, COL6A3, and ITGB1 as candidate proteins regulating the site-specific differences in morphology and metabolic function between SAT and PCAT. These findings reveal distinct morphological and proteomic features of different adipose depots in Yili horses, providing a foundation for understanding depot-specific adipose function and its underlying regulatory mechanisms. - Source: PubMed
Publication date: 2026/04/16
Yang LipingSong LirongLu ZhixinYao XinkuiWang JianwenZeng YaqiRen WanluLuo PenghuiMeng Jun - - Source: PubMed
Publication date: 2026/04/20
Chen YongWang YaqianNing XiaoyuanXu Jiayun - Abnormal paternal methylation of imprinted genes is associated with preeclampsia. C19MC is an imprinted miRNA cluster that plays an important role in placental development. Thus, the present study investigated methylation of C19MC in the spermatozoa and placentae and, its expression in the placentae of early-onset preeclampsia (EOPE). The study was carried out with n = 25 (controls) and 14 (EOPE cases). Methylation study of C19MC differentially methylated region (DMR) was performed by pyrosequencing of spermatozoa and placental villi samples. Expression levels of C19MC miRNAs in the placental villi were measured by small RNA sequencing on Illumina NovaSeq 6000. Publicly available datasets of EOPE were examined. The mRNA targets of differentially expressed miRNAs (DEMs) that were expressed in these datasets were subject to gene ontology analysis. The expression levels of target genes were quantified by qPCR. C19MC was not differentially methylated in the preeclampsia group spermatozoa. The DMR showed hypomethylation and, elevated expression of miR-518a-5p/527 and miR-520a-5p in the placental villi of the case group. The targets DAB2IP, ACAA2, TRAF2, VCAM1, CADM3, TWIST1 and CUL3 were significantly downregulated in the preeclamptic placentae. Birth weight and systolic blood pressure had a significant association with methylation in placental villi. The study is the first to explore methylation of C19MC in the spermatozoa and placentae from EOPE couples. Aberrant expression of C19MC miRNAs and their targets could be associated with pathophysiology of EOPE. The study paves the way for assessment of C19MC DEMs and target mRNAs as potential therapeutic targets for EOPE. - Source: PubMed
Publication date: 2026/03/09
Nair SwetaJoseph ShainiWarke HimangiBansal VandanaPatil AnushreeNishi KumariBalasinor Nafisa H - Obesity and its associated metabolic disorders pose a major global health challenge. Theaflavins (TFs), bioactive polyphenols derived from black tea, have demonstrated potential in alleviating metabolic diseases. This study aimed to investigate the ameliorative effects and underlying mechanisms of TFs on high-fat diet (HFD)-induced obesity from the perspectives of oxidative stress, the branched-chain amino acid (BCAA) degradation pathway, and the gut microbiota. , TFs exhibited potent free-radical scavenging capacity. , TFs dose-dependently attenuated HFD-induced weight gain, dyslipidemia and glucose intolerance. Concurrently, TF administration alleviated hepatic steatosis and ultrastructural damage and improved liver function. Importantly, TFs suppressed hepatic oxidative stress and downregulated the HFD-induced overexpression of the valine, leucine, and isoleucine degradation pathway at both mRNA and protein levels (HADH, HMGCL, ACSF3, ACADS, ALDH3A2, and ACAA2). Furthermore, gut microbiota analysis revealed that TFs improved HFD-induced gut dysbiosis, characterized by the enrichment of butyrate-producing genera (, and ) and a reduction in the relative abundance of harmful taxa (, and ). Correlation analysis integrated these findings, revealing significant associations between the TF-induced microbial shifts, the ameliorated metabolic phenotypes, and the suppressed hepatic BCAA catabolism. Our study demonstrated that the alleviation of obesity by TFs was associated with multifaceted improvements, including enhanced antioxidant capacity, amelioration of dysregulated hepatic BCAA catabolism, and modulation of gut microbial homeostasis, highlighting their potential as a dietary intervention for metabolic diseases. - Source: PubMed
Publication date: 2026/03/09
Pan RuiliWu PingZhang YifanShi XiaoleiZhang YuGu DajiangZhao Jin