Ask about this productRelated genes to: STIP1 Blocking Peptide
- Gene:
- STIP1 NIH gene
- Name:
- stress induced phosphoprotein 1
- Previous symbol:
- -
- Synonyms:
- HOP, STI1
- Chromosome:
- 11q13.1
- Locus Type:
- gene with protein product
- Date approved:
- 1999-08-25
- Date modifiied:
- 2016-10-05
Related products to: STIP1 Blocking Peptide
Related articles to: STIP1 Blocking Peptide
- Epigenome-wide association studies (EWAS) have identified associations between DNA methylation and blood pressure, yet most rely on single-time-point data and cannot capture how methylation and blood pressure relationships change with age. - Source: PubMed
Publication date: 2026/05/06
Xu GangZhuang XiaoweiAmei AmeiWang ZuohengOh Edwin C - PINK1 serves as the central regulator of PINK1-PRKN-mediated mitophagy, and its precise regulation is critical for efficient mitochondrial clearance. Although the cleavage of PINK1 and its subsequent degradation via the N-end rule pathway under basal conditions are well understood, how full-length PINK1 stability is regulated following mitochondrial damage has remained elusive. In our recent study, we identified the STUB1-VCP/p97 axis as a mechanism that fine-tunes full-length PINK1 levels during mitophagy. We demonstrate that STUB1 functions as an E3 ubiquitin ligase that catalyzes K48-linked polyubiquitination of full-length PINK1, which is subsequently recognized and extracted by VCP/p97 for proteasomal degradation. Disruption of this axis results in excessive accumulation of full-length PINK1, accelerated turnover of PRKN, and impaired mitophagy. Moreover, we find that this regulatory mechanism is compromised in the brains of patients with Alzheimer disease (AD), and its disruption leads to neuronal mitophagy defects and impaired associated learning capability in . These findings demonstrate that the STUB1-VCP/p97 complex fine-tunes PINK1 levels to ensure efficient mitophagy and preserve mitochondrial homeostasis.: AD, Alzheimer disease; CALCOCO2/NDP52, calcium binding and coiled-coil domain 2; MPP, mitochondrial processing peptidase; MQC, mitochondrial quality control; OMM, outer mitochondrial membrane; OPTN, optineurin; PARL, presenilin associated rhomboid like; PINK1, PTEN induced kinase 1; PRKN, parkin RBR E3 ubiquitin protein ligase; SILAC, stable isotope labeling by amino acids in cell culture; STUB1, STIP1 homology and U-box containing protein 1; TPR, tetratricopeptide repeat; VCP/p97, valosin containing protein; WIPI2, WD repeat domain, phosphoinositide interacting 2. - Source: PubMed
Publication date: 2026/04/16
Lin Jin-YiHuang Ze-BoFang Evandro FLu Guang - Spinocerebellar ataxias comprise a group of neurodegenerative disorders characterized by progressive cerebellar ataxia with clinical and genetic heterogeneity. Autosomal recessive spinocerebellar ataxia type 16 (SCAR16) is characterized by cerebellar ataxia accompanied by pyramidal tract damage, cognitive decline, hypogonadism, and extrapyramidal symptoms. SCAR16 is caused by mutations in the STIP1 homology and U-box containing protein 1 () gene. - Source: PubMed
Publication date: 2026/03/19
Zheng Kun-MuTang Ming-KunLi Jian-PengLiu QiBi MinWan Hui-JuanJiang Hui-WenYu Zi-WenWang JingXu Chu-ChuanWu Jing-XunXiao Nai-AnJiang Bin - DNA topoisomerase IIɑ (TOP2A) is crucial for maintaining genomic stability and is an important target for genotoxic chemotherapeutic drugs. STIP1 homology and U-box-containing protein 1 (STUB1) is a U-box containing E3 ubiquitin ligase that participates in the degradation of specific oncogenic proteins. This research examined the potential regulatory function of STUB1 in relation to TOP2A, and explored its functional implications. - Source: PubMed
Publication date: 2026/03/18
Yue BaohuiXiang QiaolingQiu HuiminHuang MingxiangQi MengxinYi XianglanZhou ShengXiong Jing - Lenvatinib is a first-line therapeutic option for advanced hepatocellular carcinoma (HCC), while acquired resistance severely limits its clinical efficacy. The precise molecular targets reversing Lenvatinib resistance remain inadequately explored. This study aims to elucidate the role of ubiquitin-specific peptidase 1 (USP1) in mediating resistance and identify potential therapeutic targets to improve treatment outcomes in HCC. - Source: PubMed
Publication date: 2026/03/13
Qiang YuweiBian SaiyanTong YunChen WeitingTang ZhangzhiDai ChengchenLiu MingyuXu BanglongJiang LihanMa KexinHe XuyangLi JinlongXiao MingbingZheng Wenjie