URG4 Blocking Peptide
- Known as:
- URG4 Blocking Peptide
- Catalog number:
- 33r-1272
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Fitzgerald industries international
- Gene target:
- URG4 Blocking Peptide
Related genes to: URG4 Blocking Peptide
- Gene:
- URGCP NIH gene
- Name:
- upregulator of cell proliferation
- Previous symbol:
- -
- Synonyms:
- URG4, KIAA1507, FLJ20654, DKFZp666G166, DKFZp686O0457
- Chromosome:
- 7p13
- Locus Type:
- gene with protein product
- Date approved:
- 2009-12-15
- Date modifiied:
- 2014-11-19
Related products to: URG4 Blocking Peptide
Related articles to: URG4 Blocking Peptide
- - Source: PubMed
Publication date: 2024/08/15
Yu DapengXu XiangyanLi SufenZhang Kai - Choroid plexus carcinomas (CPCs) are extremely rare brain tumors and carry a dismal prognosis. Treatment options are limited and there is an urgent need to develop models to further research. In the present study, we established two CPC cell lines and performed multi-omics analyses. These cell lines serve as valuable models to propose new treatments in these rare but deadly brain tumors. - Source: PubMed
Publication date: 2024/01/08
Hesham DinaOn JotaroAlshahaby NouranAmer NadaMagdeldin SamehOkada MasayasuTsukamoto YoshihiroHiraishi TetsuyaImai ChihayaOkuda ShujiroWakai ToshifumiKakita AkiyoshiOishi MakotoEl-Naggar ShahendaNatsumeda Manabu - (1) Background: Colorectal cancer (CRC) is the third most common cancer in terms of incidence and mortality. Approximately 90% of all colorectal cancer cases are adenocarcinomas, originating from epithelial cells of the colorectal mucosa. Upregulated gene 4 (URG4) is an oncogene involved in cancer development. The aim of the study was to assess the immunohistochemical expression of URG4 protein expression in Polish patients with colon adenocarcinoma who were not treated with any therapy before radical surgery. (2) Methods: The study used colon tissue samples taken from people with a confirmed diagnosis of colorectal adenocarcinoma after a thorough histopathological examination. The associations between the immunohistochemical expression of URG4 and clinical parameters were analyzed by the Chi2 test or Chi2Yatesa test. The study conducted an analysis of the correlation between the expression of URG4 and the five-year survival rate of patients through the application of the Kaplan-Meier analysis and the log-rank statistical test. The intracellular localization of URG4 was identified through the utilization of transmission electron microscopy (TEM) methodology. (3) Results: In univariate Cox regression analyses, immuno-histochemical expression of URG4, grade of histological differentiation, depth of invasion, angioinvasion, PCNA expression, stage of disease and lymph node involvement were found to be significant prognostic factors. Within our patient cohort, it was observed that the degree of tumour differentiation and URG4 expression were found to be distinct prognostic factors in regard to the 5-year survival rates of those with colon adenocarcinoma. (4) Conclusions: High immunohistochemical expression of URG4 correlates with poor prognosis in patients with colon adenocarcinoma. - Source: PubMed
Publication date: 2023/08/23
Brzozowa-Zasada MarlenaPiecuch AdamMichalski MarekStęplewska KatarzynaMatysiak NataliaKucharzewski Marek - - Source: PubMed
Publication date: 2023/03/30
Zhang ChuanlinWu YuhuaiYue QiaoningZhang XiguangHao YingluLiu Jianping - Hepatocellular Carcinoma (HCC) is the fourth leading cause of cancer-related death in the World. Epidermal Growth Factor Receptor (EGFR) pathway plays an important role in HCC tumorigenesis. In the tumor microenvironment of HCC, the expression of EGF is aberrant. Here we describe the EGF-dependent regulation of URGCP gene in Human Hepatoma cancer cells (Hep3B). The effect of EGF cytokine on Hep3B proliferation was shown using MTT method. EGF-mediated URGCP expression was determined at mRNA and protein level with qRT-PCR analyses and Western blotting method, respectively. Different lengths of URGCP promoter constructs were transient transfected in to Hep3B cells and the basal promoter activities were determined in the presence of EGF. In addition, some pathway analyses were performed to find out the mechanism of EGF mediated up-regulation of the URGCP gene. In the presence of EGF, URGCP expression increases in concentration and time dependent manner. EGF mediated URGCP up-regulation might depend on a cis-acting element located between -344 and -482 positions in its promoter. - Source: PubMed
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