Ask about this productRelated genes to: DDX41 Blocking Peptide
- Gene:
- DDX41 NIH gene
- Name:
- DEAD-box helicase 41
- Previous symbol:
- -
- Synonyms:
- ABS, MGC8828
- Chromosome:
- 5q35.3
- Locus Type:
- gene with protein product
- Date approved:
- 2003-06-13
- Date modifiied:
- 2019-04-23
Related products to: DDX41 Blocking Peptide
Related articles to: DDX41 Blocking Peptide
- Patients with lymphoid malignancies are at increased risk for second primary hematological malignancies (SPHM), due to reduced immune surveillance, genetic predispositions, and previous cancer therapies, including chemotherapy. SPHMs can substantially increase morbidity and mortality. - Source: PubMed
Publication date: 2026/04/24
J JiangS BhattaJ GallowayS LisathA SrisuwananukornN SharmaAk EisfeldN BummaSs DevarakondaE UmyarovaAe RoskoAm KhanJ WoyachDm BensonU BorateF Cottini - - Source: PubMed
Publication date: 2026/04/23
Acosta-Medina Aldo AMangaonkar Abhishek A - - Source: PubMed
Publication date: 2026/04/14
Huber SandraKornauth ChristophHutter StephanMeggendorfer ManjaSummerer IsoldeKern WolfgangHaferlach TorstenPohlkamp ChristianHoermann Gregor - Fungal keratitis (FK) is a severe, sight-threatening infection with limited therapeutic options. Although the proto-oncogene PIM1 has been implicated in various inflammatory diseases, its role and underlying mechanisms in FK remain unknown. - Source: PubMed
Han FangWang LeyiWu JiayinMa HanlinLuo XiaLi Jianqiao - A 62-year-old male presented with fatigue, dizziness, palpitations, and pancytopenia, subsequently diagnosed with myelodysplastic neoplasm (MDS) with increased blasts 2, alongside mutations in and via a targeted 521-gene hematologic disorder panel. Treatment commenced with azacitidine and supportive care, leading to transient complete remission, and the two related mutations were eliminated. However, disease relapse occurred with the emergence of a novel mutation, accompanied by two mutations detected at diagnosis. Despite adjustments in the treatment regimen, such as adding daratumumab, the patient’s disease progressed to secondary acute myeloid leukemia (sAML) with increased variant allele frequencies in three mutations. This indicated the novel mutation might be associated with AML transformation. Ultimately, after discontinuing treatment, the patient passed away. This case indicates three co-mutations, including , and , may led to rapid disease progression, and underscores the challenges in managing MDS progressing to sAML, highlighting the prognostic value of genetic mutations detected through multiple genetic tests and the need for further treatment strategies. - Source: PubMed
Publication date: 2026/03/27
Guo GuiyingCheng HuanchenSun MengLiu LixiaQin JiayueLiu YuGong Tiejun