Ask about this productRelated genes to: COCH Blocking Peptide
- Gene:
- COCH NIH gene
- Name:
- cochlin
- Previous symbol:
- DFNA31, DFNA9
- Synonyms:
- COCH-5B2
- Chromosome:
- 14q12
- Locus Type:
- gene with protein product
- Date approved:
- 1998-10-16
- Date modifiied:
- 2016-10-05
Related products to: COCH Blocking Peptide
Related articles to: COCH Blocking Peptide
- Root nodules host nitrogen-fixing bacteria and likely evolved through modifications of the lateral root program. Members of the NOOT-BOP-COCH-LIKE transcriptional coregulator family suppress root identity in nodules and plant hormones play key roles in nodule organogenesis, but the interaction between these pathways is unclear. In this study, we investigate how COCH regulates nodule identity through crosstalk with plant hormones, using the Pisum sativum cochleata (Pscoch) mutant - which forms root-nodule hybrids - in combination with hormone biosensors, double mutants, hormone quantification, and RNA-seq analysis. We found that COCH suppresses cytokinin levels and response during nodule formation. By contrast, PsCOCH promotes auxin accumulation and precise auxin response patterning in nodules. Mutant coch developing nodules have gene expression profiles more similar to that of root primordia, with increased expression of defence and auxin response genes and reduced expression of cytokinin biosynthesis genes compared to wild-type. We found gibberellin is unlikely to act downstream of PsCOCH. Constitutive expression of PsCOCH also produces root-nodule hybrids and we found intriguing links between the autoregulation of nodulation pathway and PsCOCH. We show that PsCOCH is required for spatial tight regulation of auxin and cytokinin during nodule organogenesis and identify key hormone and signalling genes that act downstream of COCH. - Source: PubMed
Publication date: 2026/05/01
Velandia KarenSohail Muhammad NoumanScott Tiana ECorrea-Lozano AlejandroMannix AlannahFoo Eloise - Triple-negative breast cancer (TNBC) is an aggressive subtype with high malignancy and poor prognosis. Immunotherapy is a promising treatment for TNBC patient. Although T cell-mediated tumor killing related genes (TTKRGs) play critical roles in antitumor immunity, their prognostic value and potential function in TNBC is still unclear. - Source: PubMed
Publication date: 2026/04/10
Zhang ChenyuHu YanminHan YongmingZhao PeipeiHan BaosanHu Xingjie - Dehydrogenation reactions are thermodynamically constrained by their inherent endothermic nature. The concomitant thermodynamic barriers can be overcome via photochemical strategies that harness light to activate intrinsically strong C═O, C─H, and O─H bonds. This review surveys recent progress and challenges in acceptorless light-driven dehydrogenation reactions, focusing on dehydrogenation of linear sp-hybridized bonds, dehydrogenative coupling reactions, dehydrogenative cyclizations, and dehydrogenation of cyclic hydrocarbons. We identified distinct trends in the catalysts used for light-driven dehydrogenations, including homogeneous unary photocatalysts in which a single molecule absorbs light and catalyzes both oxidation and hydrogen evolution, cooperative homogeneous systems in which two separate catalysts fulfill these roles, as well as heterogeneous systems including nanostructured semiconductors and hybrid materials. In particular, this work uniquely synthesizes mechanistic knowledge across these classes and introduces a unifying classification framework that clarifies how distinct photochemical mechanisms achieve bond activation and hydrogen evolution without external acceptors. First, homogeneous unary photoactive Rh(I) catalysts promote dehydrogenation of both linear and cyclic sp-hybridized C-C bonds in hydrocarbon substrates via oxidative C-H addition with subsequent β-hydride elimination. Second, binary homogeneous photocatalytic systems, consisting of a photosensitizer and a transition-metal-based proton reduction catalyst, enable all four types of dehydrogenation reactions via SET. Third, heterogeneous catalysts employed in light-driven dehydrogenation reactions often comprise a semiconductive support material integrated with a transition-metal-based active site, functioning via Mott-Schottky type photoinduced charge separation. - Source: PubMed
Publication date: 2026/04/17
Verhoef Caroline JMa RunxuanSlootweg J Chris - Congenital hearing loss (HL) in the Vietnamese population remains understudied despite its genetic diversity, limiting our understanding of its genetic etiology and hindering the development of effective, population-specific diagnostic strategies. In this descriptive cross-sectional whole-exome sequencing study, we enrolled 150 children with congenital non-syndromic HL (NSHL) from hospitals and hearing centers across Northern, Central, and Southern Vietnam to describe the genetic landscape of HL and provide new insights into rare and HL-associated variants. Clinical variant annotation was performed for 1589 deafness-associated genes, focusing on pathogenic, likely pathogenic, and variants of uncertain significance. Genetic factors strongly associated with NSHL accounted for 7.33% (11 of 150) of moderate-to-profound HL cases, involving both autosomal dominant and autosomal recessive inheritance patterns. Four variants across three genes were identified, namely GJB2:c.235del (p.L79CfsTer3), GJB2:c.109G > A (p.V37I), COCH:c.538C > T (p.R180Ter), and MYO6:c.2751dup (p.Q918TfsTer24). Two of these variants demonstrated a trend toward disease enrichment within the cohort, with the highest minor allele frequency (MAF) observed in GJB2:c.109G > A at 11%, followed by MYO6:c.2751dup at 2%. Although GJB2:c.235del showed a relatively high MAF of 1.3%, the observed minor alleles did not differ significantly from those in the East Asian and KHV control populations. These findings reveal distinct clinical and molecular profiles of congenital HL, providing essential knowledge for the development of targeted screening and diagnostic strategies tailored to the Vietnamese pediatric population. - Source: PubMed
Hoang Nguyen CongNguyen-Le Duc-MinhTran Huyen-Trang ThiNguyen Thanh TraNguyen Manh HungNgo Dai-PhuLe GiauVan-Ho Hoang-KimHa Gia HuyAnh Tran TrungHoang VietLan Le Thi HuongTuan Nguyen MinhNguyet Dao MinhGiang Bui BangThanh Le DinhNguyen Phu HungLuu Phuc-Loi - The title compound, [Fe(CH)(CHO)], was synthesized through a Claisen-Schmidt condensation. The title compound crystallizes in the monoclinic space group 2/ with four mol-ecules per unit cell. In the crystal, mol-ecules are arranged in pairs with asymmetrical stacking by O⋯H inter-molecular inter-actions. The ferrocenyl indanone derivative is involved in several inter-molecular inter-actions, including C⋯H, C⋯O, C-H⋯O, and H⋯H contacts. The cyclo-penta-dienyl rings of ferrocene exhibit an average torsion angle of approximately -15.418°. The indanone fragment and the substituted cyclo-penta-dienyl ring are nearly coplanar, forming a dihedral angle of 8.18 (14)°. The Hirshfeld surface analysis qu-anti-fied the contributions from specific inter-actions involving the carbonyl moiety, π-π stacking, and H⋯H contacts. The two-dimensional fingerprint plots and NMR spectra were also analyzed. - Source: PubMed
Publication date: 2026/03/24
Méndez-Román José ABurgos-Suazo AlejandroSantiago-Martoral Liz NPiñero Cruz Dalice MMontes-González Ingrid