Ask about this productRelated genes to: COCH Blocking Peptide
- Gene:
- COCH NIH gene
- Name:
- cochlin
- Previous symbol:
- DFNA31, DFNA9
- Synonyms:
- COCH-5B2
- Chromosome:
- 14q12
- Locus Type:
- gene with protein product
- Date approved:
- 1998-10-16
- Date modifiied:
- 2016-10-05
Related products to: COCH Blocking Peptide
Related articles to: COCH Blocking Peptide
- Environmental micro- and nanoplastics (MNPs) are increasingly recognized as biologically active particulate contaminants, yet their influence on amyloid-beta (Aβ) structural behavior and oxidative chemistry remains insufficiently defined. In this study, consumer-derived polyethylene terephthalate (PET) MNPs were used as a real-world contaminant model to evaluate time-dependent interactions with Aβ at subagglomeration peptide concentrations. Aβ solutions (0.1-1000 pg/mL) were exposed to PET MNPs (10, 40, and 100 μg/mL) for 1-144 h and assessed using fluorescence spectroscopy, apparent Stern-Volmer-type analysis, turbidity, Rayleigh light scattering (RLS), zeta potential, dynamic light scattering (DLS), FTIR, Raman spectroscopy, UV-Vis slope factor analysis, cell-free dithiothreitol oxidative potential, and molecular docking. PET MNP exposure produced wavelength-, concentration-, dose-, and time-dependent fluorescence modulation. Apparent Stern-Volmer slopes were small and bidirectional rather than uniformly positive, indicating nonclassical fluorescence behavior rather than a single dynamic quenching or binding mechanism. Turbidity and RLS increased mainly during early exposure, suggesting formation of light-scattering Aβ-MNP-associated assemblies, whereas prolonged exposure was associated with reduced scattering signals, nanoscale DLS profiles, and fluctuating zeta potentials, indicating a change in the abundance or scattering behavior of species remaining in the measured postfiltration phase. The available data cannot distinguish interfacial reorganization from microsedimentation, localized precipitation, nonspecific vessel-wall adsorption, filtration-sensitive loss, or altered scattering efficiency. FTIR and Raman results indicated changes in Amide II/III, C-O/C-H, and aromatic-residue-associated regions, while DTT results showed modest but measurable enhancement of cell-free oxidative potential. Docking simulations suggested possible PET-Aβ contacts involving aggregation-prone aromatic and polar residues, providing mechanistic support for interfacial association. Overall, PET MNPs are best interpreted as dynamic modulators of Aβ colloidal, structural, and oxidative behavior, initially favoring Aβ-MNP association and followed by later changes in the nanoscale, spectroscopic, and optical characteristics of the measured phase, without establishing a specific aggregate morphology or late-stage mechanism. - Source: PubMed
Publication date: 2026/08/13
Saygin HasanBaysal AsliApaydin EmreOzbek Pemra - Jellyfish collagen, a sustainable and biocompatible marine biomaterial, holds great potential in food and biomedical applications. This study explores the emulsification properties and therapeutic potential of pepsin-soluble collagen derived from salt-preserved (RPSC). Structural analysis confirmed that RPSC retained an intact triple-helix structure with a denaturation temperature of approximately 36.0 °C and formed elastic gels at concentrations ≥1.5% (/). As an emulsion stabilizer, RPSC (2%, /) effectively stabilized oil-in-water emulsions with oil fractions up to 50%, forming viscoelastic networks that exhibited excellent centrifugal stability but limited freeze-thaw tolerance. The gel-sol transition occurred near 38.0 °C, consistent with the thermal denaturation of RPSC. As a wound healing promoter, RPSC showed no cytotoxicity and dose-dependently enhanced 3T3 fibroblast viability, migration, and SOD activity. Notably, RPSC downregulated TGF-β1 expression and suppressed endogenous type I collagen synthesis, indicating a scar-mitigating profile distinct from conventional pro-fibrotic collagen dressings. These findings establish RPSC as a bifunctional marine biomaterial for both emulsified food systems and regenerative wound dressings in the biomedical field. - Source: PubMed
Publication date: 2026/07/01
Hu BingZong ZixinHan LingyuYao ZiangYang JixinLiu RonggangCao JijuanAl-Assaf Saphwan - Telomeres play a crucial role in chromosomal stability and cancer development. However, the prognostic significance of telomere-related genes (TRGs) in colon adenocarcinoma (COAD) remains unexplored. In this study, we aimed to establish a TRG-based prognostic model for COAD, explore its association with the tumor immune microenvironment and drug sensitivity, and offer new therapeutic targets. - Source: PubMed
Publication date: 2026/05/18
Wang ZhiyongZhang ShuominDong YiLi ZhikaiLi ZizhanLuan ZhigangWang SenLiu JipanLi Yong - The selective oxidation of ethylene (CH) and propylene (CH) offers the most important route for preparing a variety of platform chemicals. However, current industrial synthesis still relies on diversified thermo-oxidation methods, resulting in complex, inefficient, and high-cost production. Herein, we report a redox heterometallic cluster (TiMn) catalyst capable of achieving unprecedented cascade oxidation of CH and CH to divergent products in a simple photoassisted electrochemical system. In situ characterizations combined with theoretical calculations disclose that under photoelectrochemical (PEC) operation, different electron transfer processes between the peripheral Mn centers and the internal {TiO} "electron reservoir" produce multiple active oxidation states (Mn → Mn and Ti → Ti), which are able to activate multireactants and generate stabilized bromine radical (Br) and hydroxyl radical (OH) intermediates. As a result, the TiMn enables controlled tandem oxidation of CH/CH to bromoethanol (BrCHCHOH)/bromopropanol (BrCHCHOHCH), ethylene oxide (EO)/propylene oxide (PO), and bromoacetic acid (BrCHCOOH)/bromoacetone (BrCHCOCH) via shared (Br + OH)-dominated catalytic mechanisms, with high conversions (>99%), yields (up to 87%), and Faradaic efficiencies (FEs, up to 75%). Last but not least, this cascade catalytic system is applicable to a wide olefinic substrate scope as well as sustainable scaled-up production. - Source: PubMed
Publication date: 2026/06/23
Liu Jing-JingXu ShanZhang Shuai-BingChen Xiao-HongLi Run-HanShi Jing-WenChen BanglinLiu BinLan Ya-QianLiu Jiang - Regional diversity may influence the composition of human milk fat globule membrane (HMFGM) protein composition and protein glycosylation. Here, we first systematically evaluated the efficiency and stability of six methods for the extraction of HMFGM proteins from breast milk. The optimal method (methanol-chloroform precipitation of MFGM proteins, followed by solubilization in 0.4% SDS lysis buffer) was further applied to the proteome and N-glycoproteome analysis of 49 breast milk samples from five regions across China. Proteomic analysis revealed the geographically divergent expression of BST2, COCH, FUCA1 and FGFBP1 in MFGM. The parallel N-glycoproteomic profiling identified 4914 site-specific N-glycans mapping to 689 glycoproteins, 699 glycosylation sites, and 420 glycan structures. This multiomics study reveals region-specific variations in the molecular composition of HMFGM proteins and their N-glycoprotein derivatives, elucidating the structural and functional dynamics of the human HMFGM in representative regions of China. - Source: PubMed
Publication date: 2026/06/22
Cui XinlingCao JunxiaYang GuoqianMin YaoLu HaiJiang ShilongLin LingLi HongmeiYing Wantao