Ask about this productRelated genes to: COCH Blocking Peptide
- Gene:
- COCH NIH gene
- Name:
- cochlin
- Previous symbol:
- DFNA31, DFNA9
- Synonyms:
- COCH-5B2
- Chromosome:
- 14q12
- Locus Type:
- gene with protein product
- Date approved:
- 1998-10-16
- Date modifiied:
- 2016-10-05
Related products to: COCH Blocking Peptide
Related articles to: COCH Blocking Peptide
- Although hair aging affects appearance and hair quality, objective biomarkers linking molecular alterations to clinically relevant mechanical properties of hair remain limited. Here, we investigated the relationships among age, hair tensile resistance, and cortical disulfide bond content. Hair shafts from healthy volunteers (20-40 years vs. > 50 years) were analysed for tensile resistance, which was measured as maximum tensile force, and disulfide bond content was assessed by Raman spectroscopy. In parallel, human scalp hair follicles were stratified according to disulfide bond content and donor age to generate transcriptomic datasets for analysis. We identified follicular gene-expression signatures associated with these parameters. Differential expression analysis revealed a shared gene set associated with reduced disulfide bond content and age, which was subsequently evaluated in ex vivo human hair follicle cultures. Among these candidates, cochlin (COCH) emerged as a prominent candidate gene associated with higher cortical disulfide bond content and enhanced tensile resistance of the hair shaft. Immunohistochemical analysis revealed that COCH predominantly localized to the hair matrix and outer root sheath, supporting a follicle-derived contribution to shaft biochemistry. Together, these findings identify COCH as a promising candidate marker linked to disulfide bond integrity and tensile properties of human hair and establish an integrative framework for connecting follicular gene expression with age-associated changes in hair shaft mechanics. - Source: PubMed
Joo Hyun WooJeong GyusangShin Seung HyunKim Su NaKim DonghyunHam MiraKim Hyoung-JunePark Byung CheolPark Won-SeokSeo IncheolSung Young Kwan - Selective electrooxidation of ethylene glycol (EG) from polyethylene terephthalate (PET) hydrolysate to glycolic acid (GA) offers a sustainable route for plastic upcycling but is hindered by insufficient activity at industrially relevant current densities and severe catalyst deactivation caused by poisoning intermediates. Here, we design a two-dimensional ordered high-entropy intermetallic, HEI (PdPtRh)(InBi)ene, based on a PdIn-type body-centered-cubic framework. The ordered lattice induces pronounced p--d hybridization and charge redistribution, giving rise to a charge-confinement effect at the active sites. Operando infrared spectroscopy, CO stripping, and theoretical calculations reveal that this confined electronic environment precisely regulates the evolution of the key poisoning intermediate *COCHOH, weakening its accumulation while preserving efficient EG activation. As a result, HEI (PdPtRh)(InBi)ene achieves a current density of 554.21 mA cm at 0.9 V in PET hydrolysate (PETH). Furthermore, it maintains stable operation for 90 h in a flow cell at an industrially relevant current density of 200 mA cm, delivering an average GA Faradaic efficiency of 99.22% and an average GA production rate of 1.85 mmol h cm. These findings demonstrate charge-confinement engineering as an effective route to regulate poisoning-intermediate behavior in electrocatalytic alcohol oxidation. - Source: PubMed
Publication date: 2026/08/31
Yang RuidongGeng JiabingYu JiabaoXiao NingxinDeng KaiYin ShibinWang LiangYu HongjieWang Hongjing - Environmental micro- and nanoplastics (MNPs) are increasingly recognized as biologically active particulate contaminants, yet their influence on amyloid-beta (Aβ) structural behavior and oxidative chemistry remains insufficiently defined. In this study, consumer-derived polyethylene terephthalate (PET) MNPs were used as a real-world contaminant model to evaluate time-dependent interactions with Aβ at subagglomeration peptide concentrations. Aβ solutions (0.1-1000 pg/mL) were exposed to PET MNPs (10, 40, and 100 μg/mL) for 1-144 h and assessed using fluorescence spectroscopy, apparent Stern-Volmer-type analysis, turbidity, Rayleigh light scattering (RLS), zeta potential, dynamic light scattering (DLS), FTIR, Raman spectroscopy, UV-Vis slope factor analysis, cell-free dithiothreitol oxidative potential, and molecular docking. PET MNP exposure produced wavelength-, concentration-, dose-, and time-dependent fluorescence modulation. Apparent Stern-Volmer slopes were small and bidirectional rather than uniformly positive, indicating nonclassical fluorescence behavior rather than a single dynamic quenching or binding mechanism. Turbidity and RLS increased mainly during early exposure, suggesting formation of light-scattering Aβ-MNP-associated assemblies, whereas prolonged exposure was associated with reduced scattering signals, nanoscale DLS profiles, and fluctuating zeta potentials, indicating a change in the abundance or scattering behavior of species remaining in the measured postfiltration phase. The available data cannot distinguish interfacial reorganization from microsedimentation, localized precipitation, nonspecific vessel-wall adsorption, filtration-sensitive loss, or altered scattering efficiency. FTIR and Raman results indicated changes in Amide II/III, C-O/C-H, and aromatic-residue-associated regions, while DTT results showed modest but measurable enhancement of cell-free oxidative potential. Docking simulations suggested possible PET-Aβ contacts involving aggregation-prone aromatic and polar residues, providing mechanistic support for interfacial association. Overall, PET MNPs are best interpreted as dynamic modulators of Aβ colloidal, structural, and oxidative behavior, initially favoring Aβ-MNP association and followed by later changes in the nanoscale, spectroscopic, and optical characteristics of the measured phase, without establishing a specific aggregate morphology or late-stage mechanism. - Source: PubMed
Publication date: 2026/08/13
Saygin HasanBaysal AsliApaydin EmreOzbek Pemra - Jellyfish collagen, a sustainable and biocompatible marine biomaterial, holds great potential in food and biomedical applications. This study explores the emulsification properties and therapeutic potential of pepsin-soluble collagen derived from salt-preserved (RPSC). Structural analysis confirmed that RPSC retained an intact triple-helix structure with a denaturation temperature of approximately 36.0 °C and formed elastic gels at concentrations ≥1.5% (/). As an emulsion stabilizer, RPSC (2%, /) effectively stabilized oil-in-water emulsions with oil fractions up to 50%, forming viscoelastic networks that exhibited excellent centrifugal stability but limited freeze-thaw tolerance. The gel-sol transition occurred near 38.0 °C, consistent with the thermal denaturation of RPSC. As a wound healing promoter, RPSC showed no cytotoxicity and dose-dependently enhanced 3T3 fibroblast viability, migration, and SOD activity. Notably, RPSC downregulated TGF-β1 expression and suppressed endogenous type I collagen synthesis, indicating a scar-mitigating profile distinct from conventional pro-fibrotic collagen dressings. These findings establish RPSC as a bifunctional marine biomaterial for both emulsified food systems and regenerative wound dressings in the biomedical field. - Source: PubMed
Publication date: 2026/07/01
Hu BingZong ZixinHan LingyuYao ZiangYang JixinLiu RonggangCao JijuanAl-Assaf Saphwan - Telomeres play a crucial role in chromosomal stability and cancer development. However, the prognostic significance of telomere-related genes (TRGs) in colon adenocarcinoma (COAD) remains unexplored. In this study, we aimed to establish a TRG-based prognostic model for COAD, explore its association with the tumor immune microenvironment and drug sensitivity, and offer new therapeutic targets. - Source: PubMed
Publication date: 2026/05/18
Wang ZhiyongZhang ShuominDong YiLi ZhikaiLi ZizhanLuan ZhigangWang SenLiu JipanLi Yong