RDHE2 Blocking Peptide
- Known as:
- RDHE2 Blocking Peptide
- Catalog number:
- 33r-1208
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Fitzgerald industries international
- Gene target:
- RDHE2 Blocking Peptide
Related genes to: RDHE2 Blocking Peptide
- Gene:
- SDR16C5 NIH gene
- Name:
- short chain dehydrogenase/reductase family 16C member 5
- Previous symbol:
- -
- Synonyms:
- RDHE2, RDH-E2, EPHD-2
- Chromosome:
- 8q12.1
- Locus Type:
- gene with protein product
- Date approved:
- 2008-12-23
- Date modifiied:
- 2016-12-12
Related products to: RDHE2 Blocking Peptide
Related articles to: RDHE2 Blocking Peptide
- Iron is essential for both humans and pathogens, yet its genetic regulation remains understudied in African populations. Here, we report genome-wide association studies of six iron-related biomarkers in 3928 children from five sites across Africa, with replication in 2868 African American adults and investigate associations with severe malaria and bacteremia. We identify previously unreported loci at genome-wide significance, for transferrin at GTF3C5, and for hepcidin at CHCHD7/SDR16C5. Variants tagging the DUP4 haplotype, encoding the Dantu blood group (rs552439837) are associated with soluble transferrin receptor levels. Variants at GTF3C5 (rs2905094) and DUP4 confer protection against severe malaria and bacteremia. The CHCHD7/SDR16C5 variant (rs73596248) increases hepcidin levels and is associated with reduced risk of Klebsiella pneumoniae and Staphylococcus aureus bacteremia. Polygenic risk scores derived from European data show limited transferability to African populations. In this work, we demonstrate new genetic insights into iron regulation and highlight iron's role in host-pathogen interactions. - Source: PubMed
Publication date: 2026/04/07
Muriuki John MuthiiMentzer Alexander JBand GavinChong Amanda YMacharia Alex WMogire Reagan MAbuga Kelvin MokayaMitchell RuthGilchrist James JWebb Emily LNdungu Francis MRaffield Laura MEkunwe LynetteBentley Amy RSirima Sodiomon BMadhi Shabir AHill Adrian V SPrentice Andrew MBejon PhilipHemani GibranSmith George DaveySandhu Manjinder SElliott Alison MWilliams Thomas NAdeyemo AdebowaleAtkinson Sarah H - Antibodies produced by B cells aid in the recognition and clearance of pathogens and are the cornerstone of vaccination strategies. Humans produce nine different antibody isotypes, and their effector functions differ according to the type of antigen and route of exposure. Phenotypic variation between isotype-switched B cell subsets is expected but not studied in detail. To obtain a molecular definition of isotype-defined cell identity, we performed proteomics and transcriptomics on isotype-defined populations of human naive and memory B cells (MBCs): CD27IgMIgD, CD27CD38IgMIgD, CD27CD38IgMIgD, and IgA1, IgA2, IgG1, IgG2, IgG3, and IgG4 MBCs (CD27CD38Ig). Combined proteome and transcriptome analysis revealed that mRNA and protein expression profiles separate isotype-defined B cell subsets according to their differentiation status. mRNA and protein expression levels correlated reasonably well for many genes. IgG4-switched B cells were most distinct from naive B cells in terms of mRNA as well as protein expression profiles. Besides a distinct expression profile of cytokine and Fc receptors, we identified a high expression of IgE-coding mRNA in IgG4-switched B cells. SDR16C5 was identified as uniquely upregulated in IgG4-switched B cells. Taken together, this study highlights the distinct phenotypic profile of IgG4-switched B cells. - Source: PubMed
Koers JanaHoogendijk Arie JTol SimonVan Alphen Floris P JDerksen Ninotska I Lvan den Biggelaar MaartjeRispens Theo - Meibum-a lipid-rich secretion produced by holocrine Meibomian glands (MG)-plays a central role in maintaining ocular surface homeostasis in humans. Previously, changes in MG lipidomes induced by inactivation of critical genes of meibogenesis, such as , , , , and others were shown to cause MG dysfunction (MGD) and dry eye in experimental animals. Here, we describe the impact of the changes in the lipid composition of meibum on its protective properties, specifically physiologically relevant thermotropic characteristics, using various mutant and wild-type animal models, and comparing them with healthy human subjects and patients with MGD. Meibum samples were analyzed using liquid chromatography/mass spectrometry (LC/MS) and differential scanning microcalorimetry (DSC). We found that any change in the balance between major lipid classes in meibum-wax esters, cholesteryl esters, triacylglycerols, and free cholesterol-cause detrimental changes in its thermotropic properties, loss of cohesiveness, and abnormal expressibility from MG, resulting in MGD-like phenotypes of the eyes and adnexa. We conclude that tested knockout mice can be valuable models for modeling and studying MGD. A combination of LC/MS and DSC can be a powerful diagnostic tool and may help to diagnose MGD and other pathologies, as well as determine their molecular mechanisms. - Source: PubMed
Publication date: 2025/11/26
Butovich Igor AWojtowicz Jadwiga CWilkerson AmberYuksel Seher - The high molecular phenotype heterogeneity of cervical cancer (CC) is the main focus of individualized therapy. Molecular classification may lead to personal treatment and new drug discovery. We summarized the molecular features by establishing a new classification of metabolism-related gene expression profiles. - Source: PubMed
Publication date: 2025/10/29
Chen XiaohongHong CaixiaZhang GuohuiLin BixianLiu JingyiWang RonglongLi Chunbo - As one of the most widely used animal models for human disease research, pigs play a critical role in elucidating disease pathogenesis. However, the genetic characteristics of experimental pig breeds remain underexplored. This study employed whole-genome resequencing to investigate three representative Chinese indigenous pig breeds and two commercial European breeds. Our analysis revealed that indigenous breeds harbor 16.3 million genetic variants (88.3% SNPs), with higher nucleotide diversity compared to commercial breeds. Selective sweep analysis using Fst and π identified key genes under strong selection, including immune regulators (BTK, IL2RG, RASGRP1), metabolic gene MED12, and neuro-associated SDR16C5, with five genes exhibiting significant allele frequency divergence between populations (P < 0.05). Notably, two signature selective regions on chromosome 6 (181,025-182,387 bp and 144,185,871-144,313,689 bp) were identified, containing fixed missense mutations in coat color gene MC1R (p.T305C/p.G283A) and vision-related gene RPE65 (p.G1503A), indicating strong artificial selection for phenotypic traits. This work systematically characterizes the high genetic diversity of Chinese indigenous pigs and their genomic advantages as disease models, providing critical insights for developing precision biomedical animal models. - Source: PubMed
Publication date: 2025/07/01
Yuan HaonanLi ChangwenZhao ShengguoYang YananChao ZheXia ChangyouQuan JinqiangGao Caixia