Ask about this productRelated genes to: Lrp8 Blocking Peptide
- Gene:
- LRP8 NIH gene
- Name:
- LDL receptor related protein 8
- Previous symbol:
- -
- Synonyms:
- APOER2, MCI1, LRP-8, HSZ75190
- Chromosome:
- 1p32.3
- Locus Type:
- gene with protein product
- Date approved:
- 1998-08-13
- Date modifiied:
- 2015-11-13
Related products to: Lrp8 Blocking Peptide
Related articles to: Lrp8 Blocking Peptide
- Irritable bowel syndrome (IBS) is a prevalent disorder of gut-brain interactions, while the pathophysiology is intricate and current treatments mainly focus on improving symptoms. Our study aims to explore potential drug targets for IBS using Mendelian randomization (MR) analysis. - Source: PubMed
Publication date: 2026/04/23
Zhuo YudiZhao LuqingLi DanyanDing YangLiu NianWang YichongLiu JixiangShen ChenZhang Shengsheng - The twospot puffer (Takifugu bimaculatus) is a species of significant aquacultural value in East Asia, yet its production is constrained by slow growth rates and suboptimal body morphology. To advance genetic enhancement via marker-assisted selection, we conducted a genome-wide association study (GWAS) focusing on traits related to body shape. Utilizing a full-sib family comprising 167 individuals to reduce genetic variability, we employed whole-genome resequencing to identify 122,553 high-quality (SNPs) for association analysis. Our study identified 17 significant and suggestive SNP loci correlated with torso length (TL), body depth (BD), body width (BWI), head length (HL) and tail length (TAL). Functional annotation of surrounding genomic regions revealed 26 candidate genes associated with these traits, including lrp8, kank4 for TL; tfrc, dab1 for BD; pgm1, cp, rala, and cdh7 for BWI; gli3, sox17a, and zip12 for HL; myl9, smurf2 for TAL. These genes were implicated in skeletal development, cell migration, metabolism, and BMP/TGF-β signaling pathways. Our findings offered the first genetic insights into body shape in T. bimaculatus and provided valuable SNP markers for future genetic mapping of body shape related traits in multi-line famlies and marker-assisted selection breeding programs. - Source: PubMed
Publication date: 2026/04/01
Zhao HongbinWang LingzheChang YanwenLiang ShuangLiang JianLiu HuiruSong AnranLi LeibinGuo YongjunZhou Zhixiong - The hepatocellular carcinoma (HCC) immune microenvironment is heavily influenced by immunosuppressive neutrophils, yet the mechanisms driving their senescence-associated reprogramming remain elusive. - Source: PubMed
Publication date: 2026/04/01
Jiao JiazhengSong LeleXu ShengjunXue YuanLiao YanyanXu KeyingWen QianXiang KaiChen RongrongDong XiaoxiaJi WeiweiGuo YinlongLi GangBao HaibiaoXu XiaoZhan Lixing - Low-density lipoprotein receptor-related protein 8 (LRP8) is a neuronal receptor for apolipoprotein E and Reelin, two ligands critically involved in Alzheimer's disease (AD), neuronal migration, and memory. Because LRP8 is highly expressed in neurons, interacts with amyloid precursor protein, and undergoes γ-secretase-dependent processing, it has emerged as a potential contributor to AD-related neurodegeneration. Growing evidence also implicates LRP8 in carcinogenesis, highlighting the need to better define its molecular properties. This article addresses the limited understanding of LRP8 proteolytic processing, cellular localization, and molecular interactions, due in part to the lack of suitable antibodies. We present and characterize novel polyclonal and monoclonal antibodies directed against the C-terminal region of LRP8, suitable for Western blotting and immunocytochemistry/immunofluorescence. These reagents enabled detection of a previously unrecognized intracellular low-molecular-weight (∼12 kDa) C-terminal LRP8 fragment. These antibodies provide valuable new tools for mechanistic studies of LRP8. By improving the investigation of LRP8 processing and localization, they may facilitate a better understanding of its role in neurodegeneration and cancer. - Source: PubMed
Publication date: 2026/03/31
Medoro AlessandroFoderà EmanueleRonci MaurizioTrerotola MarcoMignogna DonatellaRaimo GennaroIntrieri MarianoDe Martino AnnaLepore AlessioPorcile CarolaBenincasa TeresaRusso ClaudioPassarella Daniela - ApoER2/LRP8 is a receptor highly expressed in the placenta; however, its physiological role in this organ remains poorly understood. The VLDL receptor has been less studied in the placenta. Reelin, a relevant ligand for both receptors, is an extracellular glycoprotein that participates in neuronal polarization, migration and differentiation, hence having a central role in the central nervous system (CNS) development. Reelin triggers a complex signaling pathway that regulates cytoskeleton dynamics, cell migration, differentiation and gene expression. This paper aimed to determine whether the Reelin signaling pathway plays a role in cellular processes involved in placentation. - Source: PubMed
Publication date: 2026/03/26
Sommer NicoleAlarcon-Godoy CarlosPizarro HéctorPacheco AníbalCarvajal Jorge AOlguín HugoGutiérrez JaimeLeiva AndreaMarzolo María-Paz