Ask about this productRelated genes to: CUTA Blocking Peptide
- Gene:
- CUTA NIH gene
- Name:
- cutA divalent cation tolerance homolog
- Previous symbol:
- C6orf82, ACHAP
- Synonyms:
- -
- Chromosome:
- 6p21.32
- Locus Type:
- gene with protein product
- Date approved:
- 2003-05-19
- Date modifiied:
- 2016-07-19
Related products to: CUTA Blocking Peptide
Related articles to: CUTA Blocking Peptide
- Zearalenone (ZEN), a prevalent estrogenic mycotoxin found in grains and oils, poses significant health risks due to its endocrine-disrupting properties. This study elucidates the application of a laccase-mimicking copper-tannic acid (CuTA) nanozyme as an effective catalyst for the degradation of ZEN. The CuTA nanozyme was capable of directly catalyzing the oxidation of ZEN, with optimal reaction conditions observed at a pH of 7.0 and temperatures ranging from 37 to 57 °C. The degradation products of ZEN were identified as 13-hydroxy-zearalenone (13-OH-ZEN) and 15-hydroxy-zearalenone (15-OH-ZEN). Furthermore, cytotoxicity assessments demonstrated that the CuTA nanozyme-mediated degradation of ZEN effectively reduced the hepatotoxicity of this mycotoxin. The E-screen bioassay revealed a 43.7-fold reduction in the estrogenic activity of ZEN after CuTA-mediated degradation. In corn oil, the CuTA nanozyme achieved 82% ZEN removal within 12 h and maintained 58% efficiency after four reuse cycles. These results highlight the potential use of the CuTA nanozyme to detoxify ZEN in corn oil. - Source: PubMed
Publication date: 2026/03/02
Li HongfeiRao ZhiyongGuo MingluZhang XingkeWang ZhixiangZhang WeiGuo Yongpeng - Inactive ovaries (IO) are a common reproductive disorder in early lactating dairy cows. This condition significantly reduces reproductive efficiency and economic returns. Although many studies have explored the metabolic characteristics of postpartum IO, systematic proteomic analyses using multiple biological samples are still lacking. This study used data-independent acquisition (DIA) proteomics to systematically analyze protein expression profiles in serum, follicular fluid (FF), and ovarian tissues of dairy cows. The goal was to identify potential molecular regulatory mechanisms and key biological pathways involved in IO. Serum, FF, and ovarian tissue samples were collected from six healthy and six IO multiparous Holstein cows at 63 (± 3) days postpartum. These samples were analyzed using DIA-based quantitative proteomics. - Source: PubMed
Publication date: 2026/02/09
Hao YuJiang XuejieBai YunlongXia ChengSong YuxiZheng Jiasan - Constructing integrated multifunctional hydrogels with both high toughness and diverse functionalities is beneficial for the development of flexible antibacterial materials and wearable sensors. However, current hydrogels often fail to achieve a synergistic balance among toughness, antibacterial activity, and sensing responsiveness, limiting their practical applications. Herein, a "nano-bridge" strategy is proposed to fabricate a double-network hydrogel system (PHS-CT) composed of a covalent polyacrylamide network and a dynamic borate-crosslinked hydroxypropyl guar gum/sodium alginate network. The incorporated Cu-TA nanosheets serve not only as "structural bridges" to enhance the crosslinking density and mechanical performance (strain up to 1997.7%, toughness up to 1.53 MJ/m), but also as "functional bridges" to enable photothermal conversion and improved antibacterial activity (bacterial killing rate of 99.0% against E. coli under NIR irradiation). In addition, benefiting from the dynamic reversibility of borate ester bonds as well as the re-forming capability of hydrogen bonds at the fracture interface, the hydrogel exhibits favorable self-healing ability (self-healing efficiency up to 91.0%), and can function as a flexible strain sensor capable of accurately detecting both large-scale and subtle deformations. This strategy provides a feasible strategy for constructing multifunctional dual-network hydrogels, and may be useful for photothermal antibacterial and flexible sensing applications. - Source: PubMed
Publication date: 2026/01/29
Wang JunyanWang JianhuiZhu LaixiangZhang NaXu NannanLiu FuhaoWang YanqingGao Chuanhui - In the present work, the investigation of polycrystalline nanomaterials has been extended to a specific nanoalloy of copper and tantalum having a 9:1 atomic concentration. The study aims to analyze the influence of temperature and average grain size (AGS) on the mechanical behavior of the polycrystalline Cu-Ta nanoalloy. The results indicate that the critical grain size of polycrystalline 9Cu-Ta is smaller than that of pure Cu. The critical grain size of polycrystalline Cu (6.86 nm) is reduced to 3.89 nm with the addition of approximately 10% Ta atoms. This reduction is attributed to the combined effects of dislocation slip and subgrain strengthening mechanisms. Furthermore, the investigation highlights the variation of mechanical properties with increasing temperature and the influence of temperature on the critical grain size. The analysis also reveals the existence of distinct plastic deformation mechanisms corresponding to the critical grain size in the polycrystalline Cu-Ta nanoalloy. - Source: PubMed
Publication date: 2026/02/03
Gupta Mahesh KumarRai Santosh KumarPanwar VinayMahapatra R PTevatia Abhishek - Semen cryopreservation and artificial insemination have crucial and beneficial effects on cattle breeding. The freezability of sperm, as primarily reflected by post-thaw sperm motility (PTM), is essential for evaluating semen quality. Some studies have shown notable differences in sperm freezability among various bulls. Here, we compared protein profiles of sperm cells and seminal plasma extracellular vesicles (SPEVs) in the high sperm freezability group and the low sperm freezability group of Holstein bulls to identify the important proteins and their mechanisms that affect sperm freezability. As a result, 432 and 394 differentially expressed proteins (DEPs) were identified in sperm and SPEVs between high and low freezability groups. The results of weighted correlation network analysis (WGCNA) showed that the blue module was significantly (r = 0.89, P = 9 × 10) associated with sperm freezability. In addition, the pathway analysis revealed that "Metabolic pathways" and "Oxidative phosphorylation" were the predominant biological processes represented. Furthermore, 17 DEPs were found located in the previously identified QTLs related to post-thaw sperm motility, indicating possible variation in their genes. Interestingly, the expression of 142 protein pairs in sperm were significantly (|r| >0.9, P < 0.05) correlated with their expression in SPEVs. Finally, we detected genetic variations in six important candidate genes (STK38, HSPA1A, HSP90B1, LPO, DNASE2 and CUTA), and found that a missense mutation (Chr23g. 23:27522566 A > G) in HSPA1A may affect sperm freezability by decreasing the expression of HSPA1A. Our study highlighted the different protein characteristics of sperm and SPEVs in samples with distinct sperm freezability. These proteins, together with relevant SNPs might be useful markers for selecting bulls with high sperm freezability. - Source: PubMed
Publication date: 2026/02/02
Cao JinkangLeng BingwenZhang ChunWang YachunZhang YiZheng XianruiZhang YuanpeiLi YanqinJiang Li