Ask about this productRelated genes to: NUSAP1 Blocking Peptide
- Gene:
- NUSAP1 NIH gene
- Name:
- nucleolar and spindle associated protein 1
- Previous symbol:
- -
- Synonyms:
- FLJ13421, LNP, ANKT, NuSAP1, SAPL, BM037, PRO0310p1, Q0310
- Chromosome:
- 15q14
- Locus Type:
- gene with protein product
- Date approved:
- 2003-11-05
- Date modifiied:
- 2015-03-03
Related products to: NUSAP1 Blocking Peptide
Related articles to: NUSAP1 Blocking Peptide
- Prostate cancer (PCa) is a leading malignancy in men, and understanding its molecular mechanisms is crucial for advancing therapeutic strategies. Ubiquitination, a key post-translational modification, regulates protein degradation and signaling, playing a vital role in cancer progression. This study focuses on HECTD4, a HECT-type E3 ubiquitin ligase, to identify its ubiquitination targets and understand its role in PCa. - Source: PubMed
Takashima YasuoTanaka MasamiYoshii KengoYagi TomohitoMiyagawa-Hayashino AyaTashiro Kei - This study aimed to identify shared molecular mechanisms and potential biomarkers linking lung adenocarcinoma (LUAD) and pneumonia, conditions associated with pulmonary inflammation and cancer progression. Transcriptomic datasets for pneumonia (GSE196399 and GSE202947) and LUAD (GSE19188 and GSE31210) were analyzed using the package in R. Overlapping differentially expressed genes were identified, and protein-protein interaction networks were constructed via STRING. Hub genes were screened using CytoHubba and validated through ROC, survival, and genomic analyses. Functional validation included siRNA-mediated knockdown of CCNB2 and NUSAP1 in A549 and H1975 cells, followed by RT-qPCR, Western blotting, proliferation, colony formation, and wound-healing assays. Sixty-two genes were co-dysregulated in LUAD and pneumonia. Four hub genes (CCNB2, GTSE1, TK1, NUSAP1) were significantly upregulated, showed strong diagnostic accuracy (AUC 0.75-0.90), and correlated with poor survival. Knockdown of CCNB2, NUSAP1, GTSE1, and TK1 suppressed proliferation and migration in LUAD cells. CCNB2, GTSE1, TK1, and NUSAP1 are shared molecular drivers of LUAD and pneumonia, offering diagnostic, prognostic, and therapeutic potential. - Source: PubMed
Publication date: 2026/03/27
Li ZheJu BaozhaoZhao Keming - Gastric adenocarcinoma (GAC) exhibits marked interpatient heterogeneity. Compact, biologically interpretable signatures linked to tumor-immune contexture may aid reproducible risk stratification and hypothesis generation for therapeutic responsiveness. - Source: PubMed
Publication date: 2026/03/14
Fan RuihuaWang JiruXu LijuanJin Yan - - Source: PubMed
Publication date: 2026/04/01
Chen GuojieLi WenYaGe RuomuGuo TingZhang YuhanZhou ChenglinLin Mei - Nucleolar and spindle-associated protein 1 (NUSAP1), a mitotic regulator critical for cancer cell cycle progression, remains poorly characterized in endometrial carcinoma (EC). Here, we integrated bioinformatics analysis with functional assays, including flow cytometry, Transwell invasion, ER stress imaging (ER fluorescence probe), intracellular Ca measurement (Fluo-4 AM), and Western blotting, to dissect the role of NUSAP1 role in EC. NUSAP1 was significantly overexpressed in EC tissues compared to normal controls. Strikingly, we identified a functional interaction between NUSAP1 and the inositol 1,4,5-trisphosphate receptor (IP3R), a key ER calcium release channel. Knocking down NUSAP1 suppressed EC cell proliferation and invasion while inducing mitophagy and apoptosis. These effects were accompanied by elevated cytosolic Ca levels, exacerbated ER stress, and increased phosphorylated IP3R (p-IP3R). Conversely, NUSAP1 overexpression reciprocally attenuated these phenotypes. IP3R silencing alone reduced intracellular Ca and ER stress without altering NUSAP1 expression, whereas NUSAP1 overexpression combined IP3R knockdown synergistically amplified these effects. Mechanistically, NUSAP1 governs IP3R phosphorylation to regulate Ca homeostasis, ER stress, and mitophagy, thereby modulating apoptotic signaling in EC. Our study unveils the NUSAP1-IP3R axis as a central driver of EC progression, offering novel therapeutic targets for calcium-dependent oncogenic pathways. - Source: PubMed
Publication date: 2026/01/06
Xiao HongyanWang HonghongYang HuiLi FangMa LijunMa Hongyun