Ask about this productRelated genes to: ACOT11 Blocking Peptide
- Gene:
- ACOT11 NIH gene
- Name:
- acyl-CoA thioesterase 11
- Previous symbol:
- THEA
- Synonyms:
- STARD14, BFIT, KIAA0707, BFIT1, THEM1
- Chromosome:
- 1p32.3
- Locus Type:
- gene with protein product
- Date approved:
- 2002-03-11
- Date modifiied:
- 2014-11-18
Related products to: ACOT11 Blocking Peptide
Related articles to: ACOT11 Blocking Peptide
- Colon cancer (CC), a malignancy with high global incidence and mortality, remains a major public health burden. As a pivotal aspect of tumor metabolic reprogramming, fatty acid metabolism has drawn significant research interest. This study was designed to elucidate the relationship between fatty acid metabolism-related gene expression and prognosis in patients with CC. - Source: PubMed
Publication date: 2026/03/15
Zhou ShulingChen MinDong ZhikunYang YongShi XiaoruiKang HuanShi ChangbeiWang Xuan - Colorectal cancer (CRC) is a leading cause of cancer-related death, often marked by intratumoral heterogeneity, immune evasion, and therapeutic resistance. Recent advancements in single-cell and spatial transcriptomics have enabled a deeper understanding of the tumor microenvironment (TME), revealing key insights into metabolic reprogramming and immune suppression. This study focuses on the role of sodium-overload cell death (NECSO) and its interaction with immune modulation in CRC pathogenesis. - Source: PubMed
Publication date: 2026/02/10
Ji YanchaoYu BoYin XuedongYu TianqiWu XuZhao ZongruiWang ZhengGao XiangjieZhao JiajunFang ZhihaoWang YaxuanYu Yingnan - Esophageal squamous cell carcinoma (ESCC) is a cancer with a poor prognosis, characterized by distinct geographical distribution and family clustering. - Source: PubMed
Wei Meng-XiaLei Ling-LingXu Rui-HuaLiu Yong-XuanWang RanHan Wen-LiFan Zong-MinXiao Fan-KaiSheyhidin IlyarMa LeiKu Jian-WeiYin Ming-ZhuJi Ai-FangBao Qi-DeGao She-GanHan Xue-NaLi Xin-MinChen Pei-NanZhao Xue-KeSong XinWang Li-Dong - Age-related mitochondrial dysfunction is a primary cause of muscle degeneration. We aimed to identify mitochondria-related differentially expressed genes (MR-DEGs) and construct a diagnostic model to improve the diagnosis of sarcopenia. Transcriptomic datasets GSE226151 (training) and GSE1428 (validation) were downloaded from GEO. Mitochondria-related genes (MRGs) were sourced from human MitoCarta 3.0, and MR-DEGs were screened as intersections of sarcopenia-related genes, DEGs, and MRGs. Optimal biomarkers were selected using univariate logistic regression and LASSO regression. A diagnostic model was further estimated, and the diagnostic value was determined using receiver operating characteristic (ROC) curves. Finally, interaction networks and immune correlation analyses of the optimal MR-DEGs were assessed. Six optimal MR-DEGs (ACOT11, BCO2, MRPL4, NDUFB9, UQCR10, and CASP8) were identified. The model achieved area under the curve (AUC) values of 0.935 and 0.899, respectively, in the GSE226151 and GSE1428. Significant immune correlations emerged; CD56 natural killer cells and neutrophils were correlated with MR-DEGs expression (all p < 0.05). Network analysis revealed 20 co-regulated genes that were significantly enriched in functions such as ATP synthesis-coupled electron transport, mitochondrial respiration, and oxidative phosphorylation. Our six-MR-DEG diagnostic model demonstrated a robust clinical potential for sarcopenia diagnosis, with validation across platforms and significant pathophysiological relevance to mitochondrial immune dysregulation. - Source: PubMed
Publication date: 2025/11/29
Yang XiaohuanTian MingJia ZhenyiLyu Wenke - Salidroside, a bioactive compound derived from Rhodiola, has been demonstrated to upregulate the tumor suppressor miR-1343-3p, leading to suppression of gastric cancer growth. However, the precise molecular mechanisms underlying salidroside-mediated regulation of lipid metabolism via miR-1343-3p and its downstream mRNA targets remain poorly understood. - Source: PubMed
Publication date: 2025/09/04
Zhang ZhendongCao MingyuanDu YuxinWang PingyiHou XinruiWang Xiaoping