LYK5 Blocking Peptide
- Known as:
- LYK5 Blocking Peptide
- Catalog number:
- 33r-1125
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Fitzgerald industries international
- Gene target:
- LYK5 Blocking Peptide
Related genes to: LYK5 Blocking Peptide
- Gene:
- STRADA NIH gene
- Name:
- STE20 related adaptor alpha
- Previous symbol:
- -
- Synonyms:
- NY-BR-96, LYK5, Stlk, STRAD
- Chromosome:
- 17q23.3
- Locus Type:
- gene with protein product
- Date approved:
- 2008-09-15
- Date modifiied:
- 2018-11-09
Related products to: LYK5 Blocking Peptide
Related articles to: LYK5 Blocking Peptide
- Right pulmonary vein-to-right pulmonary artery (RPV/RPA) ratio, measured at the end of the T wave, helps identify congestive heart failure in dogs with myxomatous mitral valve disease (MMVD). The aim of this study was to investigate if RPV/RPA, measured at different time points during cardiac cycle, and RPV indexed to the aortic root (Ao) would help to identify MMVD dogs in stage C. - Source: PubMed
Publication date: 2026/04/06
Patata VPorciello FRishniw MCaivano DCorda ADomenech OVezzosi TGuglielmini CPoser HSpina FBirettoni F - Torrefied hemp hurd (HH) was investigated as a sustainable filler for poly (lactic acid) (PLA)-based composites. HH, a byproduct of the textile industry, underwent torrefaction at 220, 260, and 300 °C to enhance its compatibility with PLA. The resulting fillers (HH220, HH260, HH300) were characterized in terms of morphology, structure, and thermochemical properties. Composites incorporating 2.5 and 5 wt% of each torrefied filler were prepared via melt mixing and characterized for their structural, thermal, mechanical, and tribological behavior. SEM analysis revealed that higher torrefaction temperatures resulted in improved filler dispersion and adhesion to the PLA matrix. While all composites exhibited reduced ductility (i.e., elongation at break), those containing HH300 demonstrated the highest increases in Young's modulus, tensile strength, hardness, and wear resistance. Notably, the HH300 composite containing 5 wt% showed significant improvements over unfilled PLA, including increased stiffness (+ 12%) and toughness (+ 27%), as well as substantial reductions in coefficient of friction (- 83%), and wear rate, that is reduced by about three orders of magnitude. Finally, when compared to the composite containing untreated hemp hurd, stiffness increased by 24%, toughness by 78%, with wear rate still reduced by about three orders of magnitude and friction coefficient lowered by 80%. Torrefied hemp hurd, especially when treated at high temperatures, is thus a promising bio-based reinforcement that improves the performance of PLA composites in structural and tribological applications. - Source: PubMed
Publication date: 2026/05/09
Brachi PaolaRuoppolo GiovannaFaga Maria GiuliaDi Maro MattiaMalucelli GiulioDuraccio Donatella - Aortic stenosis is a progressive fibro-inflammatory valvular disorder with major clinical burden and no disease-modifying pharmacological therapy. Defining molecular circuits associated with thrombo-inflammatory activation to extracellular matrix remodeling may enable future therapeutic targeting and biomarker development. - Source: PubMed
Publication date: 2026/05/08
Iacobucci IlariaMonaco VittoriaLobianco Alessia LubranoCipolletta BrunellaBirolo LeilaConte MaddalenaMyasoedova Veronika AValerio VincenzaPoggio PaoloParisi ValentinaMonti Maria - Growth Differentiation Factor 15 (GDF15) has been associated with different pathological conditions, including cancer cachexia. Various strategies, such as monoclonal antibodies and peptide antagonists, have been developed to inhibit GDF15 activity; however, it is currently unknown whether using small organic molecules (SOMs) can effectively target GDF15. Here, we implemented a structure-based in silico screening workflow using a curated compound library to identify SOMs with potential binding affinity for GDF15. The top-ranking SOMs predicted to interact with either the monomeric or dimeric forms of GDF15 were then tested in vitro in acellular systems, as well as in normal (dermal fibroblasts, DFs) and cancer (ovarian, OV90) cells characterized by low or high GDF15 expression levels, respectively. Among the tested SOMs, dioxoimidazolidin derivative (named SOM D) emerged as particularly promising, as resulted capable of disturbing GDF15 dimer stability and GDF15-GFRAL interaction. Furthermore, SOM D significantly modulated genes and proteins recognized as downstream of GDF15 signaling, such as IL-6 and NF-κB, particularly in OV90 cells, but not in DFs. Overall, these results support the idea that GDF15 activity could be modulated through SOMs and warrant further structure-activity optimization and quantitative target-engagement studies to assess the therapeutic potential of these scaffolds as GDF15 inhibitors. - Source: PubMed
Publication date: 2026/05/07
Chiariello AntonioLenti LorenzoTrofarello LorenzoSollazzo ManuelaLauriola MattiaDel Rio AlbertoSalvioli StefanoParenti Marco DanieleConte Maria - Membrane distillation (MD) is a thermally driven separation process that has attracted attention for its ability to couple with low-grade or renewable heat sources, making it well suited for sustainable water desalination amid rising freshwater demand and climate change pressures. A key open issue remains the optimization of fluid-dynamics within flat-sheet MD modules to minimize flow maldistribution and maximize both heat and mass transfer, and thus module performance. In this work, we numerically investigate and optimize spacer geometries - components that play a critical role in governing these transport processes. Here, using a validated computational fluid dynamics (CFD) approach, we simulate the hydrodynamics and thermal behavior of the direct contact membrane distillation (DCMD) process. Our model is first validated against published experimental data, ensuring that predicted temperature and velocity fields match observed performance metrics. We then conduct an extensive parametric study across a range of novel spacer designs - varying filament shape, orientation, and spacing - to assess their influence on flow uniformity, temperature and concentration polarization, and overall thermal efficiency. Compared to the best performing spacer configuration reported in the literature, our twisted and elliptical spacer geometries achieve up to a 5.4% reduction in temperature polarization coefficient, indicating a measurable enhancement in heat and mass transfer efficiency. These findings provide a clear roadmap for future experimental implementation of innovative spacers in MD modules, with the goal of significantly improving desalination performance and reducing energy consumption. - Source: PubMed
Publication date: 2026/05/07
Karimi SaraMorciano MatteoTurmo Carlos PlanaPiredda Matteo MariaAsinari PietroGloth OliverFasano Matteo