Ask about this productRelated genes to: SYT12 Blocking Peptide
- Gene:
- SYT12 NIH gene
- Name:
- synaptotagmin 12
- Previous symbol:
- -
- Synonyms:
- SRG1
- Chromosome:
- 11q13.2
- Locus Type:
- gene with protein product
- Date approved:
- 2002-03-17
- Date modifiied:
- 2015-11-20
Related products to: SYT12 Blocking Peptide
Related articles to: SYT12 Blocking Peptide
- - Source: PubMed
Publication date: 2026/02/21
Niu XingdongMa FubinLi FangyingWei CunchunZhang JunruiGao ZhenhuaWang JunhongDa Mingxu - Plant synaptotagmins, especially SYT1, are involved in responses to different environmental stressors. We revealed that SYT1 abundance at the cell periphery in Arabidopsis roots and its turnover decelerated upon salt stress. Results of proteomic analysis of the Arabidopsis syt1-2 allele demonstrated that under salt stress, more proteins accumulated and were depleted in the mutant than in the wild-type seedlings' roots. In both genotypes, these were mostly proteins hitherto unknown to be affected by salt stress. Proteins associated with the cytoskeleton, water deprivation, proteasome activity, oxidative stress, glutathione, lipid transfer, and glucosinolates were the most affected. When we analyzed the consequence of the mutation, 10 proteins were differentially abundant in mutant versus wild type in standard conditions, and 24 proteins under sodium chloride stress. Since these were relatively small numbers, syt1-2 was subjected to thorough molecular analysis. Results indicated that the altered SYT1 transcript was produced in syt1-2 with 75% reduced abundance compared to the unchanged transcript in the wild type. - Source: PubMed
Publication date: 2025/11/25
Kusá ZuzanaŠafránek MartinPeterková DarinaLabajová MáriaShumbusho AlainKrausko MiroslavShekhawat Gyan SDanchenko MaksymBaráth PeterJásik Ján - Synaptotagmin 12 (SYT12), a protein found to be upregulated in papillary thyroid cancer (PTC), has emerged as a potential biomarker for this malignancy. However, the mechanisms governing its expression remain poorly understood. In this study, we identify SYT12 as a novel substrate of SPOP, an adaptor of the Cullin 3 E3 ubiquitin ligase complex. SPOP binds to SYT12 and mediates SYT12's K48-linked polyubiquitination and subsequent proteasomal degradation. This interaction is dependent on the degron motif within SYT12, and deletion or mutation of the degron significantly impairs SPOP binding and stabilizes SYT12. We further demonstrate that GSK-3β-mediated phosphorylation of the degron is essential for SPOP recognition. Pharmacological inhibition of GSK-3β disrupts the SPOP-SYT12 interaction and increases SYT12 protein levels. Functionally, the SPOP-SYT12 axis modulates PTC cell viability and proliferation. Collectively, these findings uncover a novel regulatory mechanism of SYT12 expression and suggest that targeting the SPOP-SYT12 pathway may represent a promising therapeutic strategy for PTC. - Source: PubMed
Publication date: 2025/07/10
Zhou ShaochengDu QidanXu LimeiKang Xiaohong - The diameter of mature follicles in donkeys is several times larger than in cattle and sheep, but the key genes responsible for maintaining follicular development and preventing apoptosis remain unclear. - Source: PubMed
Publication date: 2025/05/20
Wang YanpingGao ZihaoZhang QiangGuo XuchuanXia WeiGu XinliZeng Weibin - This study employs integrated bioinformatics analysis and in vitro cellular experiments to elucidate the role of Synaptotagmin-12 (SYT12) in the progression of gastric cancer. - Source: PubMed
Publication date: 2024/10/29
Niu XingdongMa FubinLi FangyingWei CunchunZhang JunruiGao ZhenhuaWang JunhongDa Mingxu