Ask about this productRelated genes to: CSTB Blocking Peptide
- Gene:
- CSTB NIH gene
- Name:
- cystatin B
- Previous symbol:
- EPM1, STFB
- Synonyms:
- CST6, PME
- Chromosome:
- 21q22.3
- Locus Type:
- gene with protein product
- Date approved:
- 1996-12-12
- Date modifiied:
- 2019-04-23
Related products to: CSTB Blocking Peptide
Related articles to: CSTB Blocking Peptide
- Genetic diagnosis is increasingly crucial in medically assisted reproduction (MAR), enabling identification of infertility causes and guiding personalized treatments. This study investigates the genetic basis of empty follicle syndrome (EFS) in two independent consanguineous Algerian families with primary infertility. - Source: PubMed
Publication date: 2026/04/30
Nourine Besma Hibat AllahOunis LeylaLang CécileFeyereisen LauraZoghmar AbdelaliMilat Houssem EddineRouabah LeilaMayer ClaudineViville Stéphane - Protein N-terminal cysteines (NCys) are valuable for selective modification and posttranslational regulation, but their proteome-wide landscape remains unexplored. We constructed a library of electrophilic probes, including cyanobenzothiazole (CBT), to systematically map ligandable native NCys residues. Modifiable NCys sites were identified in proteins such as GFPT1 and CSTB, revealing accessible NCys in the human proteome. Integrating CBT into a BRD4-targeting ligand generated a reversible covalent degrader (DC = 16.7 nM, = 98%). Mechanistic studies showed that CBT modifies DCAF16 at Cys58, promoting ternary complex formation and enabling efficient ubiquitination and degradation. The platform achieved potent and selective degradation of challenging targets like EGFR and HER2 without hook effects, outperforming clinical inhibitors. This work provides the first proteome-wide map of ligandable NCys residues and establishes CBT as a versatile platform for covalent targeted protein degradation (TPD), opening new avenues for precision therapeutics. - Source: PubMed
Publication date: 2026/04/27
Zhang JixianHuang LeiLi ShengrongLi YifangTan YiLiu TongzhengLi Zhengqiu - - Source: PubMed
Publication date: 2026/04/21
Li YuLuo WenjianQian Zhang QianBai FuhaiWei JingTang LingDeng YouliangZuo DukunPeng TaotaoLi HongLong Zonghong - Persons with human immunodeficiency virus (HIV) well-treated on antiretrovirals have increased arterial inflammation, which can lead to development of atherosclerotic disease. We have previously shown that treatment with eplerenone can significantly reduce arterial inflammation, as measured by target-to-background ratio (TBR) on cardiac F-fluorodeoxyglucose positron emission tomography/computed tomography, among people with HIV. The mechanisms by which eplerenone may have treatment effects remain unclear. - Source: PubMed
Publication date: 2026/04/08
Murthy AnirudhKolossváry MártonWalpert Allie RSanchez EvaAbohashem ShadyTawakol AhmedAdler Gail KGrinspoon Steven KSrinivasa Suman - Tension band fixation (TBF) using screws or wires is the widely accepted standard of care for patellar fractures. This meta-analysis aims to quantitatively compare postoperative outcomes between Kirschner wire tension band fixation (KWTB) and cannulated screw tension band fixation (CSTB) to determine the optimal fixation method. - Source: PubMed
Publication date: 2026/04/07
Al-Naseem Abdulrahman OAli YahyaAlanzi MohammedAlotaibi LatefahAlmehandi AbdullahAltarkait AdelLari AliJarragh AliMarwan YousefBernstein Mitchell