Ask about this productRelated genes to: LHPP Blocking Peptide
- Gene:
- LHPP NIH gene
- Name:
- phospholysine phosphohistidine inorganic pyrophosphate phosphatase
- Previous symbol:
- -
- Synonyms:
- HDHD2B
- Chromosome:
- 10q26.13
- Locus Type:
- gene with protein product
- Date approved:
- 2009-11-06
- Date modifiied:
- 2016-10-05
Related products to: LHPP Blocking Peptide
Related articles to: LHPP Blocking Peptide
- Phospholysine phosphohistidine inorganic pyrophosphate phosphatase (LHPP) is a newly discovered histidine phosphatase that can remove histidine-linked phosphate groups from proteins, but its function is unclear. Given that the LHPP protein might participate in histidine phosphorylation, it is receiving increasing attention from researchers. Recent evidence has suggested that LHPP is a novel tumor suppressor with a crucial role in cancers, as its expression is decreased in different cancers. Previous studies have confirmed that abnormal LHPP levels can lead to overactivation of pathways such as the PI3K/AKT pathway during the course of tumor pathogenesis. In addition, LHPP has been confirmed as a susceptibility gene for depression, which has triggered many related studies. However, the current understanding of the functions of LHPP in diseases is relatively limited, and a systematic summary of its mechanism is lacking. Therefore, this paper reviews relevant studies of LHPP to clarify the mechanism of its involvement in cancers and nervous system diseases and provides new strategies for disease research involving LHPP. - Source: PubMed
Publication date: 2026/02/24
Cai XuanZhang YalinZhao LuChang QingZhao YuhongLiu Zhuxi - This study aimed to assess the association between regional cortical changes measured via baseline magnetic resonance imaging (MRI) and the incidence of delirium. - Source: PubMed
Publication date: 2026/02/12
Chen YanboZheng JiayuanShen RunnanCheng JinpingWang XudongLiang TongzhouSun YujunWu JionglinZheng ZhenxiangZhou TaolueLi JiajieLiu WenzhouLi YongZeng GangSong Weidong - Research demonstrates that social vulnerability has a disproportionate effect on the utilization of health care services among minority populations. The City of Lauderhill (CoL) is predominantly composed of racial/ethnic minorities, including a significant proportion of Caribbean-born and foreign-born residents, particularly from Jamaica and Haiti. CoL has one of the highest social vulnerability indices in the US and is designated by the US Housing & Urban Development (HUD) as a low-income area. The COVID-19 pandemic and existing community challenges set the stage for forming The Lauderhill Health & Prosperity Partnership (LHPP), which utilized a collaborative, multipronged approach to address the social determinants of health (SDOH). This included a community needs assessment (CNA) and Asset-Based Community Development (ABCD) grounded in Collective Impact 3.0 (CI), which leveraged a partnership with Nova Southeastern University as an academic partner and anchor institution. Population health resident data outlined in the CNA leveraged NSU's community-based participatory research platform of the Caribbean Diaspora Healthy Nutrition Outreach Project (CDHNOP) to gain valuable insight into relevant SDOH and health metrics. CDHNOP employs trusted disease prevention-focused culturally tailored health messaging through social media, health programming, and other avenues. Our specific aims were to quantify SDOH and health metrics most relevant to this diverse population and engage public and private partnerships while harnessing city residents' collective input and involvement to engage in data-driven city-wide improvements in SDOH domains. Qualitative focus group data and quantitative surveys were used in this study. A needs assessment questionnaire developed using the Protocol for Responding to and Assessing Patients' Assets, Risks, and Experiences (PRAPARE) tool was paired with existing public and city data to provide a comprehensive assessment. Findings revealed significant challenges in social and economic vulnerability within the city, with an alarming 18-fold increase in homelessness from 2020 to 2021. A total of 235 residents partially or fully completed the survey. Among respondents, 44% reported housing insecurity, 22% were unemployed, and 16% experienced food insecurity. Focus group themes emphasized barriers to healthcare, systemic distrust, and gaps in mental health access. Survey data revealed high social vulnerability scores aligning with elevated self-reported health burdens (e.g., asthma, hypertension), reflecting systemic inequities. Higher rates of overall social vulnerability were particularly pronounced in the southeast region of the city, mirroring rates of diabetes, asthma, poor physical and mental health, and smoking. Mental health, well-being of children, access to healthcare, lack of prevention and nutrition initiatives, and distrust of the healthcare system also arose as issues. These results point to a need for place-based, equity-focused interventions that align with broader national health equity frameworks, particularly for similarly diverse urban communities. - Source: PubMed
Publication date: 2025/11/25
Haffizulla FarzannaKhanna SiyaCorona Luis FAhmed AnamDunn Melissa PHardigan Patrick - Phosphorylation is set by the opposing activities of kinases and phosphatases and this regulation likely contributes to exercise-induced adaptation. It does so by regulating mitochondrial biogenesis, muscle remodeling, and metabolic flexibility. The process by which exercise activates the AMPK, MAPK, and Akt-mTOR pathways, and how phosphatases (MKP, PHLPP, and PHPT1/LHPP) limit signal amplitude and duration to avoid maladaptive behavior, has been extensively studied. Some data suggest PHLPP2 may increase after HIIT, which could contribute to limiting Akt activity. In contrast, endurance training has been associated in some studies with relatively lower PHLPP activity; this observation may be consistent with sustained Akt-dependent mitochondrial adaptations, but direct causal evidence is limited. Systems-level phosphoproteomics unveils tissue- and time-resolved, modality-dependent phosphorylation programs and situates this axis within broader PTM crosstalk (lactylation). We outline manageable gaps linking kinase-phosphatase interactions to chromatin regulation, delineate non-canonical histidine phosphorylation, and present a condensed roadmap (time-resolving, compartment-aware phosphoproteomics integrated with epigenomic profiling) that connects enzyme function to phenotype and provides precise exercise recommendations and metabolic disease therapies. - Source: PubMed
Publication date: 2025/12/10
Chen HemingLi ZhihuiLiu YanyanJi YingLiu JunjieZheng Mi - Purpurin, a naturally occurring anthraquinone pigment, has gained attention for its promising anticancer properties. This systematic-narrative hybrid review summarises current preclinical evidence on its mechanisms of action, pharmacology, and translational potential. Literature searches were conducted using PubMed, Web of Science, Scopus, and Google Scholar up to June 2025. Purpurin demonstrates selective cytotoxicity across multiple cancer models through redox imbalance, mitochondrial dysfunction, inhibition of PI3K/AKT signalling, and upregulation of the tumour suppressor LHPP. It also interferes with amino acid and glutamine metabolism and suppresses oncogenic protein aggregation. As a photosensitiser, purpurin enhances photodynamic therapy through light-activated ROS generation. Despite these promising mechanistic insights, its clinical applicability remains limited by poor aqueous solubility, rapid metabolism, and insufficient pharmacokinetic and toxicological data. Early in vivo studies indicate favourable safety, and emerging nanoparticle-based delivery systems show potential to improve bioavailability and tumour targeting. Collectively, current findings highlight purpurin as a compelling candidate for further development in oncology, particularly as part of combination or photo-enhanced therapeutic approaches. Continued research is required to address existing pharmacological gaps and to evaluate purpurin in clinically relevant models. - Source: PubMed
Publication date: 2025/12/22
Voon Fui-LingLee Yu ZhaoOoi Xiao YingTay Charlotte Zi ErnTan Ji WeiTham Chau LingHo Yu-ChengLee Ming Tatt