Ask about this productRelated genes to: CDKN1C Blocking Peptide
- Gene:
- CDKN1C NIH gene
- Name:
- cyclin dependent kinase inhibitor 1C
- Previous symbol:
- BWCR, BWS
- Synonyms:
- P57, KIP2
- Chromosome:
- 11p15.4
- Locus Type:
- gene with protein product
- Date approved:
- 1995-09-14
- Date modifiied:
- 2019-04-23
Related products to: CDKN1C Blocking Peptide
Related articles to: CDKN1C Blocking Peptide
- This study aimed to comprehensively characterize the relationship between glycated hemoglobin (HbA1c) and intervertebral disc degeneration (IVDD) by integrating population-level epidemiological profiling, Mendelian randomization (MR) analysis, multi-omics data, and single-cell transcriptomics. The objectives included clarifying the causal effect of HbA1c on IVDD, identifying key HbA1c-related genes, elucidating their cellular and molecular roles in disc degeneration, and exploring potential therapeutic targets. Global Burden of Disease (GBD) 2021 database was used to evaluate the incidence rate of diabetes mellitus (DM) and low back pain (LBP) across the entire global population. To assess the causal effect of HbA1c on IVDD, MR approache was conducted using summary statistics from large genome-wide association studies. Subsequently, integrating cis-eQTL information, bulk RNA sequencing, and single-cell RNA sequencing were performed to identify HbA1c-related genes involved in disc degeneration, and explore their roles along pseudotime differentiation trajectories. Potential associations between hub genes and IVDD, as well as candidate therapeutic compounds targeting these genes, were further evaluated through database screening and molecular docking. The findings from GBD indicated a correlation between diabetes and low back pain in both 1990 and 2021. The results of MR analysis revealed a causal relationship between HbA1c levels and IVDD. After integrated analysis of the eQTLGen database and RNA-seq data, we identified five hub HRGs, including STAT5A, CDKN1C, TRPS1, NME4, and OASL, which have been implicated in multiple biological processes and pathways associated with IVDD. Moreover, the scRNA-seq analysis showed that hub HRGs were associated with specific cell subpopulations in human nucleus pulposus (NP) tissues, such as inflamed chondrocytes, fibrochondrocytes, chondrocytes, and calcifying chondrocytes. Additionally, hub HbA1c related genes (HRGs) have been found to be associated with several DDDs such as back pain, osteoporosis, and spinal stenosis. Meanwhile, 12 drugs, including resveratrol, dexamethasone, and simvastatin, were identified that have the potential to target hub HRGs. This study revealed a causal effect of HbA1c on IVDD and identified five key HbA1c-related genes (STAT5A, CDKN1C, TRPS1, NME4, and OASL) involved in disc degeneration, providing potential targets for future research. - Source: PubMed
Publication date: 2026/03/27
Li ZhonghuiMa WeibangSun LingzhiGuo JiajieZhuang YongNing XuSun HongLiu Miao - - Source: PubMed
Publication date: 2026/03/26
Wu ShanshanZhang YananZhang HuifengYan XuePi Yalei - Genomic imprinting at the 11p15.5 region is critically involved in fetal growth regulation. Disturbances in this region are primarily associated with two opposing growth disorders: Silver-Russell syndrome (SRS, growth restriction) and Beckwith-Wiedemann syndrome (BWS, overgrowth). While epigenetic alterations are well-characterized in SRS and BWS, copy number variants (CNVs) rearrangements remain incompletely understood, particularly in terms of how duplication size and parental origin shape the phenotypic spectrum. - Source: PubMed
Publication date: 2026/03/16
Wang ChenyangZhang HengyuanWang MeiyingGao JuanLv YibingHuang JianmeiPan ShuxianWu DongKang BingHou QiaofangLiao Shixiu - Endothelial cells (ECs) are central regulators of vascular and metabolic homeostasis, yet their organ- and depot-specific diversity remains underexplored. Two major types of adipose tissue (AT) can be distinguished that differ substantially in their physiological function and vascularization: white AT (WAT), which is the major energy storage and brown AT (BAT), which is highly vascularized and dissipates energy [1-5]. While ECs from these depots likely contribute to adipose function, their characterization has been hindered by technical limitations in isolation and culture. Here, we establish a protocol for isolating and expanding ECs from murine BAT and WAT, enabling transcriptomic and functional analyses across depots. We demonstrate that freshly isolated BAT-ECs express depot-enriched gene signatures, including Rgcc, Cdkn1c, Tcf15, Meox2, and Efnb1, several of which are dynamically regulated during cold-induced BAT activation. These findings reveal novel BAT-EC markers and highlight specialized endothelial programs that may support BAT function. However, we also uncover that culturing BAT-ECs profoundly remodels EC identity. Transcriptomic profiling shows that BAT-ECs rapidly downregulate BAT-enriched endothelial markers and acquire features resembling WAT-ECs. This dedifferentiation is accompanied by signatures of proliferation, adhesion remodeling, and endothelial-to-mesenchymal transition. While these changes present challenges for maintaining depot-specific identity in culture, they also provide a framework to better interpret experimental outcomes and to investigate EC plasticity. Taken together, our study delivers a novel isolation and culture protocol for adipose ECs, defines BAT-EC markers, and demonstrates how culture conditions reshape their identity. These insights build the foundation for future research of AT vasculature. - Source: PubMed
Publication date: 2026/03/12
Elschner TabeaGrein StephanSander JanaHildebrand StaffanHeubach LaraPannwitz NinaMircea MariaRaimundez ElbaKaragiannakou VasilikiGeorgiadi AnastasiaHeeren JoergHasenauer JanPfeifer AlexanderWilhelm-Jüngling Kerstin - Spasmolytic polypeptide-expressing metaplasia (SPEM) is a gastric precancerous lesion (GPL) with high malignant potential. The ethyl acetate extract of Thunb. effectively ameliorates GPL and gastric cancer progression. Meanwhile, the primary active constituent of this plant, pristimerin, also demonstrates notable antitumor activity. - Source: PubMed
Wen Jun-SongPan Zi-WeiYao Xue-DanLiu Yan-QingZhu Yao-Dong