Ask about this productRelated genes to: CYP8B1 antibody
- Gene:
- CYP8B1 NIH gene
- Name:
- cytochrome P450 family 8 subfamily B member 1
- Previous symbol:
- -
- Synonyms:
- CYP12
- Chromosome:
- 3p22.1
- Locus Type:
- gene with protein product
- Date approved:
- 1998-06-25
- Date modifiied:
- 2015-12-09
Related products to: CYP8B1 antibody
Related articles to: CYP8B1 antibody
- - Source: PubMed
Publication date: 2026/04/21
Ling LiAli TahirLv MingyueZeng XiaoyingDuan CaixueGui ShuayanZhao Haiyan - - Source: PubMed
Publication date: 2026/04/19
Chen QiliangLiu JianWang JunqiaoYin TingWu YediZhang TianpengYu Fangjun - HeDan Capsules(HD), a traditional Chinese medicinal preparation, possesses the effects of resolving phlegm, reducing turbidity, activating blood circulation, and resolving blood stasis. It is clinically indicated for the treatment of hyperlipidemia and metabolic dysfunction-associated steatotic liver disease (MASLD). However, the mechanism by which HD ameliorates MASLD remains unclear. - Source: PubMed
Publication date: 2026/04/12
Liu HuiruWang SongsongWang NaWang FangRen JinZhou ZirongLiu KairuiWang XinyanLi YuboFu ChunshengHan Liwen - Hepatic bile acid (BA) dysregulation contributes to diarrhea in weaned piglets. Although farnesoid X receptor (FXR) is a key therapeutic target, its agonist chenodeoxycholic acid (CDCA) may exacerbate intestinal injury, underscoring the need for safer FXR-targeting strategies. In this study, BA metabolomics identified ileal accumulation of 7-ketoLCA in naturally diarrheic piglets. Mouse oral gavage confirmed the pathogenicity of 7-ketoLCA. Using AlphaFold3 and Co-IP assays, we uncover a novel interaction between FXR and vitamin D receptor (VDR) in porcine liver and TNF-α-stimulated hepatocytes. Dietary vitamin D metabolites alleviate diarrhea, reduce ileal 7-ketoLCA, and enhance intestinal barrier integrity in diarrheic piglets. These effects occur through enhanced VDR-FXR binding, which potentiates FXR transactivity. This interaction downregulates BA synthesis genes CYP7A1/CYP8B1 while upregulating export transporters BSEP/MRP2, ultimately restoring BA homeostasis and attenuating inflammatory injury. These findings reveal a VDR-FXR-mediated regulatory mechanism and support vitamin D metabolites as a safe nutritional intervention for piglet diarrhea. - Source: PubMed
Publication date: 2026/04/08
He LuWu JiyaoWang YaotongJiao YangyangZhang FengLin ZishenLiu QinghuaFeng Yue - Cold exposure remodels bile acid metabolism, but whether these changes are conserved across mouse strains and biological compartments is unclear. We profiled bile acid composition in C57BL/6J (C57) and C3H/HeJ (C3H) mice housed at 30°C or exposed to 10°C for 6, 24, or 72 h. Total, conjugated, and unconjugated bile acids were quantified in liver, plasma, and feces. In the liver, Cyp7a1 and Cyp8b1 increased after 24 h of cold in both strains, and Cyp2c70 and Cyp7b1 increased with higher levels in C3H. C57 showed decreases in taurine-conjugated muricholic acids (T-α-MCA, T-β-MCA, and T-ω-MCA) after 72 h of cold exposure, whereas C3H maintained or increased hepatic TCA, TUDCA, and β-MCA. In plasma, C57 accumulated conjugated bile acids at 72 h (TCA, TCDCA, TUDCA, and THDCA), while levels in C3H remained largely unchanged. In feces, total bile acids fell at 6 h in both strains, and conjugated species were consistently higher in C3H across conditions. C57 mice showed hepatic depletion and systemic accumulation of conjugated bile acids, while C3H maintained higher hepatic and fecal conjugates, consistent with enhanced excretory flux. These distinct profiles highlight TCA, TUDCA, β-MCA, and TCDCA as candidate bile acid species associated with cold-induced thermogenic adaptation. Together, our findings reveal that genetic background and temperature interact to shape bile acid handling and signaling, providing a framework to interpret variability in the metabolic outcomes of bile acid-based interventions. - Source: PubMed
Beji SarraMouchiroud MathildeEfole BernieGélinas YvesVerreault MélanieTrottier JocelynMichaud AndréanneBarbier OlivierCaron Alexandre