Ask about this productRelated genes to: F2RL2 antibody
- Gene:
- F2RL2 NIH gene
- Name:
- coagulation factor II thrombin receptor like 2
- Previous symbol:
- -
- Synonyms:
- PAR3
- Chromosome:
- 5q13.3
- Locus Type:
- gene with protein product
- Date approved:
- 1997-10-27
- Date modifiied:
- 2016-10-05
Related products to: F2RL2 antibody
Related articles to: F2RL2 antibody
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Publication date: 2026/03/15
Wu ZizhengZheng JieMen ShuaiSui ShuangruiYan WeitaoLiu YinfengHan Meng - Dysregulation of Ca-signaling genes has been shown in some types of cancer; however, it is virtually unknown in hepatitis B-derived hepatocellular carcinoma (HBV-HCC). Here, we evaluate the transcriptional and epigenetic regulation of Ca-signaling genes in HBV-HCC and whether their expression is associated with cancer hallmarks, and prognostic potential. - Source: PubMed
Publication date: 2026/01/27
Hernández-Martínez GuadalupeHernández-Oliveras AndrésZarain-Herzberg ÁngelSantiago-García Juan - Pancreatic ductal adenocarcinoma (PDAC) genetic susceptibility is partially identified. The complement system (CS) influences carcinogenesis and participates in immunological defense and homeostasis; however, its role in PDAC genetic susceptibility and prognosis is underexplored. The association of SNPs within 111 CS-related genes with PDAC risk is assessed in the PanGenEU study and validated in the UKBiobank. We investigate the association between the CS-related gene variation and PDAC risk, followed by an in-depth functional in silico study using TCGA and ICGC data. We assess whether CS-related genes are associated with prognosis at the germline and somatic levels. We investigate the immune infiltration of PDAC tumors according to their transcriptomic profile. Genetic variation in FCN1 and PLAT is significantly associated with PDAC risk. PDAC patients with elevated expression of IGHG3, IGKC, IGHM, F2R, F2RL2, CFI, A2M, or C4A display improved survival and higher infiltration of CD8, B cells, and Th1 cells. Individuals with high expression levels of either FGA, SERPINE1, FGG, or F3 exhibit poorer survival, higher infiltration of Tregs, and lower infiltration of CD8 cells. Results from this study suggest that CS-related genes play a role in PDAC genetic susceptibility and survival through specific immune cell infiltration. - Source: PubMed
Publication date: 2025/11/28
Langtry AlbertoRabadan RaulAlonso LolaFilip IoanSabroso-Lasa SergioMoreno-Oya AneLawlor RitaCarrato AlfredoAlvarez-Gallego RafaelIglesias MarMolero XavierLöhr Matthias JMichalski Christoph WPerea JoséO'Rorke MichaelBarberà Victor MTardón AdoninaFarré AntoniMuñoz-Bellvís LuísCrnogorac-Jurcevic TatjanaDomínguez-Muñoz EnriqueGress Thomas MGreenhalf WilliamSharp LindaBalsells JoaquimCostello EithneKleeff JörgKong BoMora JosefinaO'Driscoll DamianScarpa AldoYe WeiminReal Francisco XLópez de Maturana EvangelinaMalats Núria - While increased coagulation is linked to cancer progression, the specific roles of coagulation-related genes in colorectal cancer (CRC) have not been extensively studied. This research identified coagulation-related subtypes (CRSs) and evaluated a coagulation-related risk score for its prognostic value in CRC. - Source: PubMed
Publication date: 2025/07/24
Pei JunpengGao YuyeXing BaojianChen YongjiuWu Aiwen - To investigate the role of microRNA-5572 in the regulation of fibrosis in orbital fibroblasts (OFs) derived from patients with thyroid eye disease (TED). - Source: PubMed
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