Ask about this productRelated genes to: AGTR2 antibody
- Gene:
- AGTR2 NIH gene
- Name:
- angiotensin II receptor type 2
- Previous symbol:
- -
- Synonyms:
- AT2, MRX88
- Chromosome:
- Xq23
- Locus Type:
- gene with protein product
- Date approved:
- 1992-08-25
- Date modifiied:
- 2016-10-05
Related products to: AGTR2 antibody
Related articles to: AGTR2 antibody
- The Angiotensin II type-2 receptor (AGTR2) is a G protein-coupled receptor (GPCR) that mediates vasodilatory, anti-proliferative, and cardioprotective responses as part of the renin-angiotensin system (RAS). However, the precise structural dynamics underlying its ligand-specific activation remain incompletely understood. In this study, we performed long-timescale molecular dynamics (MD) simulations to investigate how Angiotensin peptides differentially modulate the structural dynamics of AGTR2 in both inactive- and active-like conformations and to elucidate ligand-specific modulation of AGTR2 in the RAS protective arm. Ang II stabilized a 'Locked Active State' through compact TM3-TM6 distances, persistent hydrogen bonding (PHE8-LYS215), salt bridges (ARG2-ASP279, ARG2-ASP297), hydrophobic contacts (TRP100, MET128), and rotameric locking of micro-switches. These interactions stabilized Helix 8, enhancing dynamic network connectivity and supporting ligand-dependent activation-related conformational tendencies rather than a full canonical GPCR activation transition. Conversely, Ang1-7 induced a 'Flexible Intermediate State' characterized by weaker interactions (PRO7-THR125), dynamic instability at the Helix 8 interface, and increased conformational sampling. Activation motif analyses (CWxP, PIF, E/DRY, NPxxY), DCC maps, CP, DRIN metrics, and PCA confirmed distinct signaling features for each ligand. This study provides a dual functional profile for AGTR2, where Ang II acts as a strong conformational stabilizer promoting activation-related dynamic features, while Ang 1-7 serves as a dynamic modulator. These findings contribute to a structural and dynamic framework for understanding AGTR2 signaling and supporting its therapeutic potential in fine-tuning cardiovascular responses within the RAS. - Source: PubMed
Publication date: 2026/07/20
Yasar EkremDogru SegunEroglu ErolYaras Nazmi - Coarctation of the aorta (CoA) is a congenital narrowing of the aortic isthmus near the ductus arteriosus or ligamentum arteriosum. Despite successful anatomical repair, patients remain at risk of recoarctation, arterial hypertension, and diffuse aortopathy, suggesting intrinsic vessel-wall abnormalities beyond localized obstruction. The developmental and molecular basis of these persistent vascular features remains incompletely understood. Human aortic tissue samples were obtained from 8 male infants with CoA and 6 age- and sex-matched controls aged <1 year. Total RNA was isolated, and gene expression profiling was performed using whole human genome oligo microarrays (Agilent). Differentially expressed transcripts were subjected to pathway, network, and upstream regulator analyses using Ingenuity Pathway Analysis (IPA, Qiagen). Selected candidate genes were evaluated by RT-qPCR in independent verification sets. Transcriptomic profiling identified 402 analysis-ready transcripts distinguishing CoA from control tissue. Exploratory pathway analyses suggested extracellular matrix remodeling characterized by collagen turnover, integrin-mediated cell-matrix interactions, wound-healing signaling, and fibrosis-associated programs. In addition, enrichment analyses identified developmental annotations involving retinoic acid (RA)/RAR/RXR signaling, -associated developmental programs, and a shared -associated signature. Network and upstream regulator analyses further suggested associations with cytoskeletal, muscle-associated, and epigenetic regulatory pathways, including , , retinoic acid/RAR/RXR signaling, , , and RT-qPCR independently confirmed increased expression of , , , and Infantile CoA tissue exhibited molecular signatures consistent with vessel-wall remodeling accompanied by developmental, vascular signaling, and smooth muscle/cytoskeletal regulatory programs. These findings support the hypothesis that developmental patterning signals and postnatal extracellular matrix remodeling coexist within CoA tissue and may contribute to persistent vascular abnormalities beyond anatomical repair. Given the exploratory nature of the study, these observations should be considered hypothesis-generating and require validation in independent cohorts. - Source: PubMed
Publication date: 2026/07/03
Robl Isabell GCesnjevar RobertEkici Arif BUebe SteffenJohann Pascal DRamirez Maria Daniela HernandezFincke Victoria EFahlbusch Fabian BMoosmann Julia - Differential fecundity in goats is a complex trait governed by coordinated molecular regulation across reproductive and endocrine tissues. In this study, we performed integrated metabolomic profiling of follicular fluid, serum, thyroid tissue, and uterine luminal fluid together with transcriptomic sequencing of follicular, thyroid, and uterine horn tissues from high-fecundity (HF) and low-fecundity (LF) Yangtze River Delta White goats. In addition, weighted gene co-expression network analysis (WGCNA) was conducted to elucidate the molecular mechanisms underlying differential litter size. High-fecundity goats exhibited enhanced follicular steroidogenesis, superior corpus luteum function, and more stable hypothalamic-pituitary-thyroid (HPT) axis activity, accompanied by increased uterine gland density and greater myometrial thickness. Metabolomic profiling identified 6640 metabolites displaying tissue-specific differential abundance patterns. Pathway enrichment analysis highlighted steroid hormone biosynthesis and energy metabolism in follicular fluid, PPAR signaling and tyrosine metabolism in thyroid tissue, and glycerophospholipid and one-carbon metabolism in uterine luminal fluid as major pathways associated with fecundity. Transcriptomic analysis identified 1596 differentially expressed genes (DEGs), including 20 genes shared across all examined tissues, constituting a systemic molecular signature associated with fecundity. WGCNA further revealed three functional tissue axes associated with follicular development (, , ), thyroid endocrine regulation (, ), and uterine receptivity (, , ). Low-fecundity-associated modules were predominantly concentrated in follicular and thyroid tissues, whereas the high-fecundity-specific module was mainly enriched in uterine horn. These findings provide a multi-tissue molecular framework underlying differential fecundity in goats and identify candidate hub genes and metabolites that may serve as candidate biomarkers for fecundity assessment and selective breeding programs. - Source: PubMed
Publication date: 2026/07/02
Sun JiahaoTang WenjunMalyar Rahmani MohammadShi Fangxiong - Activation of the angiotensin II type 2 receptor (AT receptor; encoded by ) has been shown to be beneficial during tissue injury and repair. Therefore, we aimed to investigate the expression of AT receptor in human alveolar type II (ATII) cells, a cell population responsible for lung repair and regeneration, and the effect of the AT receptor agonist buloxibutid (also known as C21), in an model of viral infection using primary ATII cells. - Source: PubMed
Publication date: 2026/07/06
Conforti FrancoBell JosephRidley RobertDean LarebLoxham MatthewParkin JamesAlzetani AimanJones Mark GDalsgaard Carl-JohanRaud JohanDavies Donna E - This research investigates the correlation between nine polymorphic variants and the incidence of hypertension and its clinical manifestations in the Ellikqala District in the Republic of Karakalpakstan, Uzbekistan. This district is known as one of the most challenging areas for human habitation due to its high salinity levels in the environment, which contribute to a higher prevalence of cardiovascular diseases. - Source: PubMed
Publication date: 2026/07/06
Ataniyazov KhurshidZakirova Darya VladimirovnaMeylikov KhurshidKhamidullaeva GulnozAbdullaeva GuzalTurdikulova ShahloFozilov KhurshidAbdullaev Alisher