Ask about this productRelated genes to: AGTR2 antibody
- Gene:
- AGTR2 NIH gene
- Name:
- angiotensin II receptor type 2
- Previous symbol:
- -
- Synonyms:
- AT2, MRX88
- Chromosome:
- Xq23
- Locus Type:
- gene with protein product
- Date approved:
- 1992-08-25
- Date modifiied:
- 2016-10-05
Related products to: AGTR2 antibody
Related articles to: AGTR2 antibody
- Nonsynonymous single nucleotide polymorphisms (nsSNPs) in angiotensin Type II receptor () have been identified as a potential cause of cardiovascular illness in humans. Identifying structurally and functionally relevant alterations in is critical to investigate possible therapeutic targets. - Source: PubMed
Publication date: 2026/04/15
Waleed Iqbal MuhammadShahab MuhammadSun XinxiaoAkter ShahinaZheng GuojunShazly Gamal ABourhia MohammedDauelbait MusaabYuan Qipeng - Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by deficits in communication, social interaction, and behavioral regulation. Its etiology arises from a combination of genetic vulnerabilities and environmental influences. Bisphenol A (BPA) is an endocrine-disrupting chemical found in plastic-containing materials, including micro- and nanoplastic pollutants. Recent studies have shown that prenatal BPA exposure can alter behavior and the expression of genes related to autism and neurodevelopment. - Source: PubMed
Publication date: 2026/04/17
Sukjamnong SupornSaeliw ThanitPanjabud PawineeThongkorn SurangratKanlayaprasit SongphonLertpeerapan PattanachatHu Valerie WSarachana Tewarit - Geese are key domesticated waterfowl in Asia, where annual egg number and laying duration influence economic value. To investigate the genomic basis of laying seasonality, we generated whole-genome resequencing data for 314 geese from six Chinese breeds and focused on three with contrasting reproductive schedules: low-latitude Ding'an geese, which have a prolonged laying period with moderate annual egg yield, and high-latitude Huoyan and Zi geese, which show short, highly seasonal laying but high egg production. By integrating Fst, GWAS and haplotype-based statistics, we identified 16 candidate genes, including reproduction-related loci (AGTR2, IARS, PCGF6) and retinal genes (FRMD4B, PROS1, SH2D3C, ZEB2). Genomic regions surrounding PCGF6 and PROS1 showed clear signatures of selection, with reduced nucleotide diversity and strongly differentiated haplotypes between latitude-defined groups. Multiple downstream and 3' untranslated-region SNPs at these loci exhibited large allele-frequency shifts and are predicted to alter transcriptional regulation, suggesting a link between retinal photoreception, photoperiodic or circadian signaling and the timing and duration of egg laying. These findings highlight the role of retinal pathways in goose reproductive seasonality and provide targets for genomic selection to potentially extend the laying period. - Source: PubMed
Publication date: 2026/03/24
Chen HaoMiao JunjieHu YimingZhou JingTan HongliLi JingMao HuirongOuyang JingHuang MinGu LihongYan Xueming - To explore the mechanisms underlying ocular infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), we conducted a comprehensive review of current literature, focusing on viral entry pathways, receptor expression in ocular tissues, and associated clinical manifestations. This review encompasses studies published within the last five years with a focus on original research and systematic reviews that provide molecular, histological, or clinical evidence. The findings show that SARS-CoV-2 can infect ocular tissues through multiple receptors beyond angiotensin-converting enzyme 2 (ACE2), including transmembrane serine protease 2 (TMPRSS2), CD147, alanyl aminopeptidase N (ANPEP), dipeptidyl peptidase 4 (DPP4), angiotensin II receptor type 2 (AGTR2), and polymeric immunoglobulin receptor (PIGR), which are expressed in retinal, conjunctival, corneal, limbal, and photoreceptor cells. The virus may also reach ocular structures neurovascular invasion. Clinically, patients with coronavirus disease 2019 (COVID-19) may present with a broad spectrum of ophthalmic manifestations, including conjunctivitis, hyperreflective lesions in the inner retinal layers, flame-shaped hemorrhages, cotton-wool spots, retinal pallor, hard exudates, and various forms of maculopathy, such as paracentral acute middle maculopathy and acute macular neuroretinopathy (AMN). These signs reflect both direct viral damage and secondary effects of systemic inflammation and microvascular injury. Understanding the molecular and clinical spectrum of ocular involvement is essential for early diagnosis, appropriate ophthalmologic care, and the prevention of long-term visual sequelae in patients affected by COVID-19. - Source: PubMed
Publication date: 2026/03/18
González SamuelArellano JhesuaReza-Zaldivar Edwin EstefanMena-Munguía SalvadorMinjarez BenitoRodríguez-Yáñez Yury - The Post-COVID syndrome is associated with the generation of autoantibodies to vasoregulative G-protein coupled receptors (GPCR). It remains elusive, however, whether these autoantibodies play a pathophysiological role in this disease. The present study investigates whether detection and concentration of GPCR autoantibodies are related to vascular function in patients with Post-COVID. - Source: PubMed
Publication date: 2026/02/24
Seibert Felix SKurucay MelisaWiemers LeaStervbo UlrikSander OliverSegelbacher MonikaSeidel MaximilianBertram SebastianBabel NinaWesthoff Timm H