Ask about this productRelated genes to: MRGPRX2 antibody
- Gene:
- MRGPRX2 NIH gene
- Name:
- MAS related GPR family member X2
- Previous symbol:
- -
- Synonyms:
- MRGX2
- Chromosome:
- 11p15.1
- Locus Type:
- gene with protein product
- Date approved:
- 2005-05-09
- Date modifiied:
- 2015-11-23
Related products to: MRGPRX2 antibody
Related articles to: MRGPRX2 antibody
- Anaphylaxis represents the most severe and potentially fatal manifestation of allergic disease, characterized by sudden multi-system involvement and rapid hemodynamic compromise. While management protocols have improved, global incidence continues to rise and preventable deaths persist - driven largely by delayed epinephrine administration and inadequate long-term follow-up. This narrative review synthesizes current evidence on the immunological and non-immunological mechanisms underlying anaphylaxis, evaluates diagnostic criteria from major allergy societies, and appraises both immediate and long-term treatment strategies. Contributing factors to persistent morbidity - including epinephrine underuse, barriers to autoinjector access, and the emergence of biphasic and refractory phenotypes - are examined in depth. Advances in novel epinephrine delivery platforms, biologic therapies targeting the IgE and cytokine axes, and immunomodulatory strategies including oral and venom immunotherapy are highlighted as promising avenues for improving outcomes. This review also underscores the need for validated predictive biomarkers, equitable device access, and prospective trials to close the gaps that continue to drive preventable mortality. - Source: PubMed
Publication date: 2026/04/06
Ellorin ArisAgrawal Devendra K - The Hewei Jiangni Prescription (HP) is a traditional Chinese prescription, which has shown clinical benefits for many years in non-erosive reflux disease (NERD)-associated esophageal hypersensitivity. However, its mechanism of effects remains unclear. - Source: PubMed
Publication date: 2026/04/22
Wang JialiPei WenjingShi LeiMao TangyouChen XiaoweiLiu JialiCheng YuanJiang HuiHuang HaoHu JuncongZhang ShuangyuanLi XiaohongLi Junxiang - Antibiotics are urgently needed against drug-resistant bacterial infections. We report synthetic peptides with dual antimicrobial and immunomodulatory action. These peptides activate the human Mas-related G protein-coupled receptor-X2 (MRGPRX2) and its mouse ortholog, Mas-related G protein-coupled receptor-B2 (MRGPRB2), while directly killing bacteria. Unlike traditional MRGPRX2 agonists, these peptides contain protease-resistant d-amino acids, enhancing their stability. In a mouse infection model, the peptides demonstrated antimicrobial efficacy, and activated human MRGPRX2 but not its G165E missense variant. They also stimulated tumor necrosis factor alpha (TNF-α), C-C motif chemokine ligand 3 (CCL3), and interleukin-8 (IL-8) release in human mast cells via MRGPRX2 and triggered degranulation in mouse mast cells via MRGPRB2. The peptides increased vascular permeability, promoted neutrophil and monocyte recruitment, and cleared infections in wild-type but not mice. These findings suggest that synthetic peptides can target G protein-coupled receptors (GPCRs), leveraging mast cell immunomodulation to treat antibiotic-resistant infections. This study opens avenues for designing peptides and other molecules against infections by targeting GPCRs expressed in mast cells. - Source: PubMed
Amponnawarat AetasTorres Marcelo D TKrishnan Rakeshde la Fuente-Nunez CesarAli Hydar - Antibodies are central mediators of the adaptive immune response, and they are powerful research tools and therapeutics. Antibody discovery requires substantial experimental effort, such as immunization campaigns or in vitro library screening. Predicting antibody-antigen binding a priori remains challenging. However, recent machine learning methods raise the possibility of in silico antibody discovery, bypassing or reducing initial experimental bottlenecks. Here, we report a virtual screen using AlphaFold-Multimer (AF-M) that prospectively identified nanobody binders to MRGPRX2, a G protein-coupled receptor (GPCR) and therapeutic target for the treatment of pseudoallergic inflammation and itch. Using previously reported nanobody-GPCR structures, we identified a set of AF-M outputs that effectively discriminate between interacting and non-interacting nanobody-GPCR pairs. We used these outputs to perform a prospective in silico screen, identified nanobodies that bind MRGPRX2 with high affinity, and confirmed activity in signaling and functional cellular assays. Our results provide a proof of concept for fully computational antibody discovery pipelines that can circumvent laboratory experiments. - Source: PubMed
Publication date: 2026/04/23
Harvey Edward PSmith Jeffrey SHurley Joseph DGranados Alyana JSchmid Ernst WLiang-Lin Jason GZhang HuyangMeara Emily MWren Elizabeth KPaul SteffanieFerguson Matthew PCalvillo-Miranda Victor GAlcantar Miguel AMarks Debora SWalter Johannes CKruse Andrew CSusa Katherine J - Phosphoinositides (PIs) regulate mast cell (MC) secretory granule (SG) biogenesis and exocytosis, yet their compartment-specific roles in receptor signaling and secretion remain unclear. Using a rapamycin-inducible dimerization system to recruit site-specific lipid phosphatases to either the plasma membrane or the SGs, we assessed the impact of spatially restricted PI depletion on secretion triggered by FcεRI activation, the MRGPRX2 ligand substance P (SP), or receptor-independent calcium/phorbol ester stimulation. Our data reveal distinct and shared PI requirements for coupling FcεRI and MRGPRX2 signaling to the exocytic machinery and uncover PI derivatives that act locally at the SGs to modulate granule release. Together, these findings show that individual PIs differentially orchestrate allergic and neurogenic secretion pathways and fine-tune SG exocytosis through site-specific functions. - Source: PubMed
Publication date: 2026/03/21
Omari-Manaa SewarAharonov RoselynGalli Stephen JAli HydarSagi-Eisenberg Ronit