Ask about this productRelated genes to: PHYHIPL antibody
- Gene:
- PHYHIPL NIH gene
- Name:
- phytanoyl-CoA 2-hydroxylase interacting protein like
- Previous symbol:
- -
- Synonyms:
- KIAA1796, Em:AC025038.1
- Chromosome:
- 10q21.1
- Locus Type:
- gene with protein product
- Date approved:
- 2004-04-16
- Date modifiied:
- 2016-02-01
Related products to: PHYHIPL antibody
Related articles to: PHYHIPL antibody
- To investigate the correlation between the expression levels of microRNA-199a-3p (miR-199a-3p) and Fibronectin 1 (FN1) in serum and aqueous humor and the severity of Type 2 Diabetic Retinopathy (DR) in a Chinese population. - Source: PubMed
Publication date: 2026/04/28
Chen YangChen NianlinMeng XiangruiLinghu MinliHuang YikengHuang Xionggao - Pork is a major source of animal protein for humans, and as living standards have improved, consumer demand has shifted from quantity to quality. Amino acid and fatty acid compositions determine the nutritional value and flavor of pork. However, the genetic mechanisms underlying variation in these parameters have not been fully elucidated. In this study, we quantified 17 amino acids and 42 fatty acids in the muscle from three crossbred pig populations, namely Yorkshire × Tibetan (YT), Yorkshire × Neijiang (YN), and Duroc × Tibetan (DT). YT and YN pigs exhibited higher amino acid concentrations, while DT pigs showed elevated fatty acid levels. Subsequently, whole-genome resequencing of 73 pigs identified 24,125,658 high-quality SNPs, among which 146 were significantly associated with fatty acid traits, leading to the identification of 19 candidate genes linked to palmitic acid (i.e., , and ), oleic acid (i.e., , and ), and total fatty acids (i.e., ). Functional annotation revealed that these candidate genes participate primarily in pathways related to lipid metabolism, glucose homeostasis, and energy balance. The identified SNPs and candidate genes provide valuable insights into the genetic architecture of the fatty acid composition in pork and may serve as molecular targets for improving meat quality through breeding. - Source: PubMed
Publication date: 2026/01/29
Tang JieLiang YanAn RuiLuo GanTao XuanLiu PengliangGu Yiren - The Dietary Approaches to Stop Hypertension (DASH) diet reduced low-density lipoprotein (LDL)-cholesterol (C) and non-high-density lipoprotein (HDL)-C levels compared to the control diet. However, the mechanisms underlying the relation between the DASH diet and lipoprotein levels are not fully understood. We identified DASH diet-related proteins that were differently associated with LDL-C and non-HDL-C in two randomized controlled feeding studies comparing a DASH to control diet (DASH and DASH-Sodium trials). Two proteins [collagen triple helix repeat-containing protein 1 (CTHRC1) and growth differentiation factor 8 (MSTN)], and one protein [phytanoyl-CoA hydroxylase-interacting protein-like (PHYHIPL)], were differentially associated with changes in LDL-C and non-HDL-C, respectively, in the DASH and DASH-Sodium trials ( for interaction <0.05 for all tests). All proteins, except MSTN, were higher among those who consumed the DASH control diets. All proteins were associated with reductions in lipoprotein levels among those who were provided with the DASH diets (range of = -3.69 to -1.76) and elevations among those who were provided with the control diets (range of = 0.20 to 3.47). Proteins involved in the TGF-β pathway and inflammatory processes that were lowered by the DASH diet were associated with reductions in LDL-C and non-HDL-C levels. Clinical Trial registration number: NCT03403166 (DASH trial), NCT00000608 (DASH-Sodium trial). - Source: PubMed
Publication date: 2025/11/10
Kim HyunjuLichtenstein Alice HCoresh JosefAppel Lawrence JRebholz Casey M - Mortality from preeclampsia (PE) and PE-associated morbidities are 3-to 5-fold higher in persons of African ancestry than in those of Asian and European ancestries. - Source: PubMed
Publication date: 2023/10/20
Aisagbonhi OmonighoBui TonyNasamran Chanond ASt Louis HaileePizzo DonaldMeads MorganMulholland MeganMagallanes CelestineLamale-Smith LeahLaurent Louise CMorey RobertJacobs Marni BFisch Kathleen MHorii Mariko - Glioma is a common intracranial tumor and is generally associated with poor prognosis. Recently, numerous studies illustrated the importance of 5-methylcytosine (m5C) RNA modification to tumorigenesis. However, the prognostic value and immune correlation of m5C in glioma remain unclear. We obtained RNA expression and clinical information from The Cancer Genome Atlas (TCGA) and The Chinese Glioma Genome Atlas (CGGA) datasets to analyze. Nonnegative matrix factorization (NMF) was used to classify patients into two subgroups and compare these patients in survival and clinicopathological characteristics. CIBERSORT and single-sample gene-set algorithm (ssGSEA) methods were used to investigate the relationship between m5C and the immune environment. The Weighted correlation network analysis (WGCNA) and univariate Cox proportional hazard model (CoxPH) were used to construct a m5C-related signature. Most of m5C RNA methylation regulators presented differential expression and prognostic values. There were obvious relationships between immune infiltration cells and m5C regulators, especially NSUN7. In the m5C-related module from WGCNA, we found SEPT3, CHI3L1, PLBD1, PHYHIPL, SAMD8, RAP1B, B3GNT5, RER1, PTPN7, SLC39A1, and MXI1 were prognostic factors for glioma, and they were used to construct the signature. The great significance of m5C-related signature in predicting the survival of patients with glioma was confirmed in the validation sets and CGGA cohort. - Source: PubMed
Publication date: 2023/11/06
Xiao ZhenyongLi JinweiLiang CongLiu YameiZhang YuxiuZhang YuxiaLiu QuanYan Xianlei