Ask about this productRelated genes to: OPN3 antibody
- Gene:
- OPN3 NIH gene
- Name:
- opsin 3
- Previous symbol:
- ECPN
- Synonyms:
- ERO, NMO-1, encephalopsin, PPP1R116
- Chromosome:
- 1q43
- Locus Type:
- gene with protein product
- Date approved:
- 2000-11-24
- Date modifiied:
- 2014-11-19
Related products to: OPN3 antibody
Related articles to: OPN3 antibody
- Myopia, or near-sightedness, is a growing global concern as its incidence rate continues to dramatically rise. It has been linked to significant ocular morbidity and reduced quality of life. Despite this, much is still largely unknown about the development of and the mechanisms driving the pathogenesis of myopia. As such, myopia prevention and myopia mitigation treatment strategies are occasionally ineffective, can be difficult to adhere to, and have diminishing returns over time. Recently, non-visual opsins (OPN3, OPN4, and OPN5) have emerged as potentially impacting myopia regulation. This narrative review aims to summarize the current understanding of the non-visual opsins and how they might influence myopia. In addition, this review explores how utilizing this knowledge can help develop promising future treatment strategies to reduce the incidence and severity of myopia. - Source: PubMed
Publication date: 2026/01/31
Gettinger KateTsubota KazuoNegishi KazunoKurihara Toshihide - Abnormal lipid metabolism is a key feature of many diseases. Therefore, investigating its underlying mechanisms is of great importance. Recently, blue light has shown promise as a drug-free way to influence energy metabolism, relying on the light-sensitive protein Opsin 3 (Opn3). This study aimed to investigate the effects of blue light irradiation on lipid droplet degradation in cells and its molecular mechanism, while also evaluating its potential antiviral effects. The results demonstrate that exposure to 470-480 nm blue light significantly reduced oleic-acid-induced intracellular lipid droplet accumulation and decreased triglyceride and total cholesterol levels, an effect dependent on the Opn3. It was found that blue light affects the Pparα signaling pathway through Opn3, and, at the same time, blue light and Opn3 promote autophagy mediated by p62 protein, thereby cooperatively regulating lipid droplet degradation. In Opn3 knockout cells, blue-light-induced lipid droplet degradation, nuclear accumulation of Pparα, and autophagic effects were all suppressed. Additionally, the study unexpectedly observed that blue light, via Opn3, significantly suppressed the replication of VSV, H1N1 and EMCV and alleviated virus-induced cell death and inflammatory responses. This study reveals the critical role of the blue light-Opn3-Pparα/p62 axis in regulating lipid droplet degradation in hepatocytes and identifies a novel antiviral function of Opn3-mediated blue light exposure. These findings provide a new theoretical basis and potential targets for innovative therapeutic strategies against metabolic diseases and viral infections. - Source: PubMed
Publication date: 2026/01/08
Wu QifanLiu HuipingLiang HongcuiJiang XinyiQin YingqiaoLiang ShaomeiWang JingjingLiu Kunpeng - Photoreception is common in animals without a visual system. In animals with visual systems, it is sometimes presumed that the same photoreceptors and pathways will accommodate both visual and non-visual light detection. However, mounting evidence reveals that most animals exhibit broad extra-visual photoreceptive functions that are wholly independent of the visual system. One of these functions is the synchronization of the circadian clock to light-dark signals, or photoentrainment. In mammals, behavioral photoentrainment is achieved exclusively through visual and non-visual opsin proteins within the retina, and molecular photoentrainment of individual cells occurs using non-visual opsins in some peripheral tissues. This is in contrast to insects and fish where nearly all peripheral organs are directly photoentrainable. This review will summarize the family of opsins in mammals and focus on the role of non-visual opsins in circadian photoreception. Particular emphasis will be given to photoentrainment in other vertebrates in order to compare and contrast the use of the wide range of non-visual opsins in circadian photoentrainment throughout the animal kingdom. - Source: PubMed
Publication date: 2026/01/03
Buhr Ethan DVan Gelder Russell N - Sarcopenia is an ageing-related disease characterised primarily by skeletal muscle functional decline. Despite of fatty acid metabolism (FAM) affecting oxidative stress within muscle tissue, the key roles of critical genes linking FAM and sarcopenia are unclear. The GSE8479, GSE1428, and GSE136344 datasets were downloaded and intersected for identifying FAM-related differentially expressed genes (FAMRDEGs) screened by enrichment analysis, LASSO regression, and Support Vector Machine (SVM) analyses. Cytoscape software was used for visualising mRNA-transcription factor (TF) and mRNA-miRNA networks. In addition, ROC curves of key genes were plotted to evaluate their diagnostic significance. A Fatty Acid Metabolism Score (FAM-Score) was conducted and immune cell infiltration analysis was conducted. The qPCR assay was performed to analyse the levels of screened critical genes. A total of 109 FAMRDEGs were obtained, and the LASSO regression and SVM models screened 14 of these genes. The network included 7 key genes with 54 miRNAs and 9 hub genes with 102 TFs. There were 6 types of immune cell infiltration showing statistical significance. The FABP3 (P < 0.001), PECR (P < 0.01), and OPN3 (P < 0.001) mRNA expression markedly increased in sarcopenia versus control groups. In contrast, sarcopenia group showed remarkably reduced PCTP (P < 0.001), SREBF2 (P < 0.001), and PPARGC1A (P < 0.05) levels. This study provides reference indicators for FAM-associated auxiliary biomarkers of sarcopenia and preliminarily establishes effective machine learning models for further mechanistic exploration. - Source: PubMed
Yang RuopengGu ShanLi YangXia Ping - To elucidate the genetic mechanism underlying body color variation within a single breeding family of captive Yellow River carp (Cyprinus carpio haematopterus), individuals exhibiting normal and aberrant pigmentation from the same concrete pond were selected for analysis. Using bulked segregant analysis combined with whole-genome resequencing, DNA pools were constructed from progeny with extreme phenotypes for sequencing. SNP variation detection followed by linkage analysis identified a candidate region on chromosome 25, spanning approximately 10.1 Mb (from 15,881,284 bp to 26,645,798 bp). Gene Ontology (GO) enrichment analysis revealed four candidate genes potentially associated with aberrant pigmentation: dkk1, kndc1, lyst, and opn3. Based on the candidate genes' mutation sites, certain primers were created, and the PCR products were then sequenced. Notably, a mutation was detected at the 8th bp of the opn3 cDNA corresponding to transcript HHLG25g0668 in the aberrant-color offspring. At this position, 81.25 % of wild-type individuals carried the cytosine (C) allele, whereas all mutant individuals carried an adenine (A) substitution, resulting in an amino acid change from serine to tyrosine at position 3 of the protein. This suggests that opn3 may play a key role in the development of abnormal pigmentation in Yellow River carp. These findings provide a theoretical foundation for further functional studies of pigmentation-related genes and the genetic improvement of novel germplasm in Yellow River carp. - Source: PubMed
Publication date: 2025/11/28
Liu YingChang LeWang LingranLiu ChangFeng DiWang Lei