Ask about this productRelated genes to: ARR3 antibody
- Gene:
- ARR3 NIH gene
- Name:
- arrestin 3
- Previous symbol:
- -
- Synonyms:
- ARRX
- Chromosome:
- Xq13.1
- Locus Type:
- gene with protein product
- Date approved:
- 1994-08-04
- Date modifiied:
- 2016-07-08
Related products to: ARR3 antibody
Related articles to: ARR3 antibody
- : Early-onset high myopia (eoHM), defined as high myopia manifesting before 10 years of age, is largely attributed to genetic defects. This study aimed to investigate the genetic underpinnings of eoHM in a cohort of Chinese patients. : We recruited 64 Chinese patients with eoHM. Comprehensive clinical evaluations were performed, and whole exome sequencing (WES) was conducted to identify potential pathogenic variants. The genetic findings were analyzed and correlated with the clinical phenotypes. : A total of 64 unrelated Chinese patients with suspected early-onset high myopia were initially recruited. Following whole exome sequencing (WES) and variant annotation, final 37 patients with variants in known myopia-associated genes were included in the analytical cohort. The mean age of onset for the cohort was 5 years (IQR, 4-7), with a mean spherical equivalent refraction of -7 D (IQR, (-8)-(-6)). Genetic analysis revealed variants in 28 known myopia-associated genes. We identified pathogenic or likely pathogenic variants in 11 of the 37 patients (29.7%, 95%CI: 0.1737-0.4590), while the overall diagnostic yield was 17.2% (11/64, 95%CI: 0.0970-0.2839) in initial 64 recruited patients. These genes included seven well-established eoHM-related genes, such as ARR3, CACNA1F, P4HA2, TRPM1, COL11A1, COL2A1, and PAX6. Additionally, variants of uncertain significance (VUS) in seven other candidate genes were detected in patients with eoHM. : Our findings expand the genetic spectrum of eoHM and reinforce the critical role of genetic testing in its etiological diagnosis and clinical management. Observed patterns of genotype-phenotype associations are descriptive and should be considered hypothesis-generating, requiring validation in larger cohorts. Additionally, we identify several candidate genes that may serve as prospective biomarkers, though these findings require validation in larger cohorts and functional studies. - Source: PubMed
Publication date: 2026/03/29
Liu XueChu HuihuiSun YaruZhao HaixiaYu Jifeng - : The emergence of carbapenem-resistant enterobacteriaceae (CRE) co-harboring the gene and carbapenemase-encoding genes poses a severe threat to public health. Urban wastewater treatment plants (WWTPs) act as natural reservoirs and hotspots for the dissemination of antimicrobial resistance genes (ARGs). This study aimed to elucidate the molecular characteristics of CRE carrying in urban WWTPs. : Samples were collected from the influent of urban WWTPs in Fengxian, Shanghai, from April 2024 to March 2025. -positive isolates were screened using real-time PCR, and their antimicrobial susceptibility was determined via the broth microdilution method. Plasmid conjugation assays were performed with as the recipient strain. Whole-genome sequencing (WGS) was carried out to analyze the molecular characteristics of -positive isolates. : A total of 312 samples were collected, and 5 (1.6%) -positive isolates were identified. All isolates were multidrug-resistant (MDR) but susceptible to tigecycline (TIG). WGS of strain EC0176 (sequence type 156 [ST156], enteroaggregative [EAEC]) detected the presence of , and as well as related virulence genes. Further analysis revealed that pEC0176 was an IncHI2-type plasmid co-harboring , and . The plasmid pEC0176 harbored similar backbones as p20014-MCR, p2017.03.02CC_1, pSC2017167-mcr-256k, pEC17CM13_MCR and pGDE043-mcr1, including the type IV secretion system (T4SS) and IncHI-type conjugal transfer genes. Conjugation experiments confirmed that pEC0176 could be horizontally transferred into C600, with an average transfer efficiency of 3.3 × 10. Phylogenetic analysis showed that the MCR-1 protein of EC0176 is closely related to that of two human-derived strains from China (GenBank accession: AVR64822.1 and WP_076611062.1). : To our knowledge, this is the first report of ST156 carrying an IncHI2-type plasmid co-harboring and from urban WWTPs in Fengxian, Shanghai. Our findings underscore the severe status of bacterial antimicrobial resistance and emphasize the necessity of enhancing antimicrobial resistance surveillance in urban WWTPs. - Source: PubMed
Publication date: 2026/03/06
Zhang QingyuanXie XiaohongTao LixinWang JianShi YuanSheng HuangfeiLiu ChuanlongZhao HongweiLiu MeihuaFeng Jun - Identification of genetic variations associated with early-onset high myopia (eoHM) provides a genetic basis for risk assessment and prevention of this disease. - Source: PubMed
Publication date: 2026/02/25
Han ChunxiaoWu ShanshanYang YangYang XiangchunLi Haibo - X-linked female-limited high myopia (MYP26, OMIM:301010) is a rare Mendelian subtype of early-onset high myopia (eoHM), with females having progressive myopic refractive error (≥-6 D) and males as asymptomatic carriers. Pathogenic variants in (OMIM:301770) have been linked to eoHM, but the spectrum of variants in Chinese populations remains incompletely defined. - Source: PubMed
Publication date: 2026/02/03
Zhang JianpingZhao YijiaLan YueyuanLiu WenhuiZhong PeiWang Binbin - - Source: PubMed
Publication date: 2026/01/09
Yu JiaheZhang JieJiang YaqinMa ChunliWang WenjingZhang KaihuiTian RujinChen HaisuHan HaitaoSun HuixinPeng ChuanzhiZhang HanXu Xinyan