Ask about this productRelated genes to: STARD8 antibody
- Gene:
- STARD8 NIH gene
- Name:
- StAR related lipid transfer domain containing 8
- Previous symbol:
- -
- Synonyms:
- KIAA0189, ARHGAP38
- Chromosome:
- Xq13.1
- Locus Type:
- gene with protein product
- Date approved:
- 2002-08-28
- Date modifiied:
- 2015-11-20
Related products to: STARD8 antibody
Related articles to: STARD8 antibody
- Anorectal malformations (ARM) and hypospadias are common congenital anomalies that occasionally co-occur, suggesting shared developmental pathways. Despite their clinical significance, the genetic etiology of combined ARM-hypospadias remains poorly understood. - Source: PubMed
Publication date: 2025/11/01
Goswami ChandramouliSharma JyotiSardar RahilaGupta DineshKumar SourabhJain VisheshDhua Anjan KumarYadav Devendra KumarSingh HarpreetGoel Prabudh - Prostate cancer (PCa) is one of the most prevalent malignancies among men, with its incidence and mortality rates rising globally, posing a significant threat to men's health. STARD8, an emerging tumor suppressor gene, has been reported to inhibit cancer cell proliferation and migration in certain cancers. However, its role in PCa remains inadequately understood. - Source: PubMed
Publication date: 2025/05/08
Xu ZichuangChen XiaojianHe YeyingTong JiayingChen ChaoyueDing MeiqingChen WeiZhou HuiliangZheng XiaohuiXiao Yunbei - Egg weight (EW) and age at first egg (AFE) are economically important traits in breeder chicken production. The genetic basis of these traits, however, is far from understood, especially for broiler breeders. In this study, genetic parameter estimation, genome-wide association analysis, meta-analysis, and selective sweep analysis were carried out to identify genetic loci associated with EW and AFE in 6,842 broiler breeders. The study found that the heritability of EW ranged from 0.42 to 0.44, while the heritability of AFE was estimated at 0.33 in the maternal line. Meta-analysis and selective sweep analysis identified two colocalized regions on GGA4 that significantly influenced EW at 32 wk (EW32W) and at 43 wk (EW43W) with both paternal and maternal lines. The genes AR, YIPF6, and STARD8 were located within the significant region (GGA4: 366.86-575.50 kb), potentially affecting EW through the regulation of follicle development, cell proliferation, and lipid transfer etc. The promising genes LCORL and NCAPG were positioned within the significant region (GGA4:75.35-75.42 Mb), potentially influencing EW through pleiotropic effects on growth and development. Additionally, 3 significant regions were associated with AFE on chromosomes GGA7, GGA19, and GGA27. All of these factors affected the AFE by influencing ovarian development. In our study, the genomic information from both paternal and maternal lines was used to identify genetic regions associated with EW and AFE. Two genomic regions and eight genes were identified as the most likely candidates affecting EW and AFE. These findings contribute to a better understanding of the genetic basis of egg production traits in broiler breeders and provide new insights into future technology development. - Source: PubMed
Publication date: 2024/03/05
Ma XiaochunYing FanLi ZhengdaBai LuWang MengjieZhu DanLiu DaweiWen JieZhao GuipingLiu Ranran - 46,XY gonadal dysgenesis is a condition that is characterised by undeveloped testes in individuals with a male karyotype. Mutations in many genes that underlie this condition have been identified; however, there are still a considerable number of patients with an unknown genetic background. Recently, a mutation in the STARD8 X-linked gene in two sisters with 46,XY gonadal dysgenesis has been reported. It was localised within the START domain, whose homologue in Drosophila is responsible for maintaining testes integrity during their development. - Source: PubMed
Publication date: 2024/03/08
Sirokha DmytroRayevsky AlexeyGorodna OlexandraKalynovskyi VitaliiZelinska NataliyaSamson OksanaKwiatkowska KrystynaNef SergeJaruzelska JadwigaKusz-Zamelczyk KamilaLivshits Ludmila - StAR-related lipid transfer domain protein 8 (STARD8), encoding a Rho-GTPase-activating protein, and WNK2, encoding a serine/threonine kinase are candidate tumor suppressor genes (TSGs) in human cancers. Inactivation of these genes that would promote cancer pathogenesis is largely unknown in colon cancer (CC). Our study addressed to address whether STARD8 and WNK2 genes are mutated in CC. STARD8 and WNK2 genes possess mononucleotide repeats in their exons, which could be the targets for frameshift mutations in cancers with high microsatellite instability (MSI-H). By single-strand conformation polymorphism (SSCP) analysis, we analyzed the repeated sequences in 140 CCs (95 CCs with MSI-H and 45 CCs with stable MSI (MSS)). By DNA sequencing, we found that five MSI-H CCs (5/95: 5.3%) harbored the frameshift mutations, whereas MSS CCs (0/45) did not. In addition, we detected regional heterogeneous frameshift mutations of these genes in four (25%) of 16 MSI-H CCs. In immunohistochemistry for WNK2, WNK2 expression in the MSI-H CCs was significantly lower than that in the MSS CCs. Our results for the mutation and expression indicate that STARD8 and WNK2 genes are altered at various levels (frameshift mutation, expression, and regional heterogeneity) in MSI-H CCs, which might play a role in the pathogenesis by inactivating their TSG functions. - Source: PubMed
Publication date: 2023/12/01
Mo Ha YoonMoon Seong WonAn Chang HyeokLee Sug Hyung