Ask about this productRelated genes to: Pdyn antibody
- Gene:
- PDYN NIH gene
- Name:
- prodynorphin
- Previous symbol:
- SCA23
- Synonyms:
- PENKB, ADCA
- Chromosome:
- 20p13
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2019-04-23
Related products to: Pdyn antibody
Related articles to: Pdyn antibody
- Stress can cause or exacerbate psychiatric illness, and effects on the transcription factor CREB within the nucleus accumbens (NAc) are critically involved. In rodents, stress-induced activation of NAc CREB produces elevations in dynorphin (DYN), an endogenous opioid expressed in dopamine D1-receptor (D1R)-expressing medium spiny neurons (MSNs). In turn, elevated DYN signaling produces features of mood and anxiety disorders via actions at kappa-opioid receptors (KORs). Although individual differences in stress sensitivity have been described-with some appearing susceptible and others resilient-the contribution of NAc DYN to these phenotypes is unclear. Here we examined relationships between social behavior and DYN in D1R-expressing MSNs in mice exposed to chronic social defeat stress (CSDS). We used quantitative (q)RNAscope to assess co-expression of genes encoding CREB ( ), D1Rs ( ), and DYN ( ) within the NAc. To leverage individual variability, we performed regression analyses across all mice, revealing negative correlations between social interaction behavior and expression of and , linking higher social avoidance with higher expression of these genes. There was no correlation with , suggesting stress-induced elevations in depend on CREB activation (phosphorylation). These findings suggest that stress-induced elevations in D1R-associated DYN signaling within the NAc is a biomarker of susceptibility. - Source: PubMed
Publication date: 2026/04/24
Burek DominikaCarlezon William A - Spinocerebellar ataxia type 23 (SCA23) is a rare autosomal dominant hereditary ataxia caused by a pathogenic variant in the gene. It usually presents in adulthood, with a mean age of onset around 43 ± 15 years (reported range: 10–73 years), and progresses slowly with cerebellar symptoms. We report a case of a Brazilian 25-year-old female patient whose symptoms began at 19 years of age, characterized by progressive dysarthria, tremor, dysphagia, and gait disturbance. She had no relatives with similar symptoms. The initial genetic ataxia panel, which included the most prevalent hereditary ataxia genes, was negative. Subsequent next-generation sequencing identified a pathogenic variant in the gene, confirming the diagnosis of SCA23. Brain MRI demonstrated significant cerebellar atrophy. The patient was referred to a multidisciplinary rehabilitation group with emphasis on functional rehabilitation of gait and dysphagia. This case is notable for the rarity of SCA23 in the Americas, the relatively young age at onset compared with the reported mean age in the literature, while still remaining within the previously described age range, and the absence of a family history of ataxia or other neurological symptoms, despite SCA23 having an autosomal dominant inheritance pattern. - Source: PubMed
Publication date: 2026/04/20
Saadeh Victor Monteiro DiasNassif DanielVasconcellos Luiz Felipe - Prenatal opioid exposure (POE) can disrupt the development of dopamine and opioid systems, potentially altering behavioral sensitization in adulthood. - Source: PubMed
Publication date: 2026/04/10
Aaron Chantal C AVassoler Fair MByrnes Elizabeth M - Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized by deficits in social communication and repetitive behaviours. Sensory processing abnormalities are now recognized as a core feature of ASD and have been extensively studied. While differences in sensory profiles between individuals with and without ASD are well established, the genetic underpinnings of sensory variability within the ASD population remain unclear. The opioid system is believed to play a role in processes such as social behaviours, pain, addiction, reward, mood, cognition and perception. This study aimed to investigate the relationship between ASD, sensory differences and prodynorphin (PDYN) gene polymorphisms. - Source: PubMed
Başkaya Gülsüm DemirkanŞahin NilferBilgiç Ayşegül DemirtaşTopal HaticeYazıcı Özlem NehirDombaycı ÖzgeEdgünlü Tuba - Psychological stress is believed to exacerbate dermatitis, yet the neurobiological mechanisms linking stress to immune processes remain elusive. We identified a subset of prodynorphin-positive (Pdyn) noradrenergic sympathetic neurons in mice that specifically innervate hairy skin, mediating stress-induced exacerbation of skin inflammation in an eosinophil-dependent manner. Genetic ablation of Pdyn sympathetic neurons or eosinophils mitigated stress-evoked worsening of inflammation in atopic dermatitis-like mice, whereas optogenetic activation of these neurons precipitated inflammation through eosinophils. Pdyn sympathetic neurons recruited eosinophils through the CCL11-CCR3 axis and activated them through the adrenergic receptor beta2 (Adrb2) in inflamed skin. Our findings reveal a neuroimmunological mechanism underlying psychological stress-induced exacerbation of dermatitis, emphasizing the Pdyn sympathetic-eosinophil axis as a crucial interface between the brain and skin inflammation, with potential therapeutic implications. - Source: PubMed
Publication date: 2026/03/19
Tian JiaheCao YudianLi YileiSun JunlongZhan ChengNi WeiZheng YongjunWang YanqingLiu Shenbin