Ask about this productRelated genes to: SSTR2 antibody
- Gene:
- SSTR2 NIH gene
- Name:
- somatostatin receptor 2
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 17q25.1
- Locus Type:
- gene with protein product
- Date approved:
- 1992-08-25
- Date modifiied:
- 2016-10-25
Related products to: SSTR2 antibody
Related articles to: SSTR2 antibody
- Naturally occurring pain and itch disorders in the domestic dog represent an important and underexploited opportunity for translational sensory neuroscience. These conditions largely mirror human disease, highlighting the need for detailed comparative understanding of canine somatosensory neurobiology. Here, we present a single-cell transcriptomic characterisation of the canine dorsal root ganglion (DRG), providing molecular insights into sensory neuron diversity in a species of direct veterinary and biomedical relevance. We develop a novel mechanical dissociation and fluorescence-activated cell sorting strategy enabling purification of intact whole neurons from adult canine DRG, followed by deep, full-length RNA sequencing using FLASH-seq. This approach yields high-quality transcriptional profiles with molecular depth analogous to deep neuronal profiling in human DRG, enabling resolution of neuronal identities and subtype-specific gene programs. Using these data, we identify canine sensory neuron clusters conforming to conserved principles of DRG molecular organization observed across species, including peptidergic and noncanonical peptidergic nociceptors, low-threshold mechanoreceptors, proprioceptors, and thermosensory populations. Cross-species comparisons with human and mouse DRG datasets reveal broad conservation of pain- and itch-relevant pathways and therapeutic targets, alongside biologically meaningful divergence. We further identify species-specific differences in subtype-restricted expression of the pharmacologically relevant receptors IL31RA and SSTR2, which we validate using in situ hybridization and contextualize with human spatial transcriptomic data. Finally, we provide evidence that domestication-associated genes are nonrandomly enriched in specific sensory neurons, suggesting that evolutionary history may have shaped somatosensory function. These data represent a resource for comparative sensory neuroscience and inform translational interpretation of pain and itch therapeutics across species. - Source: PubMed
Publication date: 2026/09/02
Ledesma Fernandez PaulaButler BrandiTheis HeidiPaulusch StefanDe Domenico ElenaWeir Greg ABell Andrew M - Uterine small cell neuroendocrine carcinoma (SCNEC) is a highly malignant and aggressive neoplasm. When chemotherapy is necessary, a platinum-based regimen similar to that used for pulmonary SCNEC is recommended. We encountered two cases of uterine SCNEC expressing somatostatin receptor type 2 (SSTR2), both with minor components of endocervical adenocarcinoma (ECAC). This study aimed to clarify the histogenesis and progression of these carcinomas through detailed histopathological, immunohistochemical, and mutation analysis, in order to contribute to the development of treatment strategies. - Source: PubMed
Publication date: 2026/09/01
Bamba MasamichiNamura TomoKato ToshikazuShiohara MasanoriIsogawa KenjiUemura MaoWakinoue ShiroYomo HirokoNakagawa TetsuyaKatsumori TetsuyaKushima RyojiMoritani Suzuko - Somatostatin receptor 2 is expressed in nasopharyngeal carcinoma (NPC). We report genomic and transcriptomic analysis results of 163 NPC cases, demonstrating that somatostatin receptor 2 (SSTR2) gene expression in EBV-positive and in EBV-negative NPC correlated with genomic alterations and an inflamed microenvironment. Median SSTR2 expression was 6.52 transcripts per million (TPM), ranging from 0.59 TPM (Quartile 1 [Q1], 18.2% EBV-positive) to 35.79 TPM (Q4, 82.9% EBV-positive). PIK3CA (20.51%) and CYLD (10.53%)/NFKBIA (12.82%) mutations were enriched in SSTR2-Q1 versus -Q4. Tumor mutation burden was negatively correlated (R = -0.27, p < 0.001) with SSTR2, while PD-L1 tumor proportion score (2% vs. 92.5% [SSTR2:Q1 vs. Q4], p < 0.001) and T-cell inflamed score correlated with SSTR2 expression (R = 0.53, p < 0.001). B-cells, M1 macrophages, CD8+ T-cells, Treg cells, and dendritic cells were enriched in SSTR2-Q4, while neutrophils were prominent in SSTR2-Q1. These results demonstrate a significant positive correlation between SSTR2 expression and an inflamed tumor microenvironment in NPC. This suggests that SSTR2 expression in NPC may be a clinically useful biomarker, correlating with the tumor microenvironment (including, potentially, sensitivity to immunotherapy) and its genetic profile. - Source: PubMed
Bracken-Clarke DaraXue ElisabettaKrause HarrisAdeyelu TolulopeEvans Mark GAkbulut DilaraQuezado MarthaGandhi NishantFarrell AlexSoares Heloisa PLou EmilPhan MinhPatel RushaVanderwalde Ari MElliott AndrewSteuer Conor ESaba Nabil FLubin Daniel JLondon Nyall RGulley James LFloudas Charalampos S - Somatostatin receptor (SSTR)-targeted PET imaging is increasingly used in the management of meningiomas. While gallium-68-labeled tracers are widely used, fluorine-18-labeled compounds may offer logistical and imaging advantages. We evaluated the feasibility and imaging characteristics of the novel SSTR ligand [¹⁸F]SiTATE PET/CT in patients with suspected or known meningioma. - Source: PubMed
Publication date: 2026/08/29
Sachpekidis ChristosHadjitheodorou PanayiotisKonstantinidou KyriakiKyrou KyriakiAdamou GiorgosFesas AndreasPourkhessalian Mohammad RTsechelidis IoannisVrachimis Alexis - Cardiovascular events such as myocardial infarction (MI) show an early morning peak, suggesting circadian regulation of cardiac vulnerability. However, the mechanisms through which sleep loss may contribute to time-of-day myocardial risk remain unclear. We examined whether insomnia-associated circadian and thrombotic alterations are associated with morning cardiac vulnerability. Rats were subjected to pharmacologically induced insomnia using -chlorophenylalanine (PCPA), isoproterenol-induced myocardial stress, and their combination. Temporal profiling across zeitgeber times (ZTs) assessed locomotor activity, biochemical markers (melatonin, serotonin, and cardiac troponin I), cardiac electrophysiology, and coagulation parameters. Integrative transcriptomic analysis was performed using human insomnia and MI data sets. Experimentally, insomnia and myocardial stress altered rest-activity, temporal electrophysiology, biochemical, and coagulation circadian profiles, and the combined condition showed the most pronounced alterations. These included changes in cardiac conduction and repolarization indices, altered melatonin rhythmicity, altered serotonin levels, elevated troponin I, reduced clotting time, and increased platelet aggregation, predominantly during ZT6-ZT12, corresponding to the light-dark transition, analogous to the human early morning phase. PCPA effects were restricted to the light phase, whereas ISO-containing groups showed sustained alterations. Integrative transcriptomic analysis identified a candidate circadian-thrombotic molecular signature involving CRY1, F2R, LEP, SSTR2, and IL7R, with mRNA profiling in rats showing altered Cry1 expression in heart and Lep expression in both SCN and the heart, suggesting altered SCN-heart coordination under combined insomnia and MI. These findings suggest a shift toward a pro-thrombotic cardiac profile during the early day window with insomnia-associated circadian alterations, supporting future investigation of circadian-informed chronotherapeutic approaches for morning cardiac vulnerability. - Source: PubMed
Publication date: 2026/07/31
Kumar NeerajSiddiqui Mohammad AquibKrishnamurthy Sairam