Ask about this productRelated genes to: ERC1 antibody
- Gene:
- ERC1 NIH gene
- Name:
- ELKS/RAB6-interacting/CAST family member 1
- Previous symbol:
- RAB6IP2
- Synonyms:
- ELKS, KIAA1081, CAST2, MGC12974
- Chromosome:
- 12p13.33
- Locus Type:
- gene with protein product
- Date approved:
- 2004-11-26
- Date modifiied:
- 2016-10-05
Related products to: ERC1 antibody
Related articles to: ERC1 antibody
- Oppositely charged polyelectrolytes are known to form polyelectrolyte complexes. Polyelectrolyte complexes are typically structurally disordered. In recent years, complexes of oppositely charged polypeptides have received increasing attention. Polypeptides provide additional interaction motifs such as hydrogen bonds and salt bridges that could stabilize ordered assemblies. Under specific conditions, the formation of secondary structures has been reported. So far, it has been difficult to obtain long-range ordered assemblies of polypeptide complexes. Here we show that liquid-solid phase separation of oppositely charged homopolypeptides spontaneously leads to the formation of extended polypeptide helices that form highly ordered hexagonally or square-packed helix arrays with helix-helix distances of 1.6-2.0 nm. The helices exhibit an additional periodic staggering along their axis with a periodicity of 15 - 30 nm, equal to the length of the extended helices. This hierarchical helix assembly was demonstrated for polyarginine assembled with polyaspartic acid or polyglutamic acid as examples. The materials can be shear-aligned to achieve macroscopic uniaxial orientation of the helices. Crosslinking leads to solid elastic materials. Upon heating to temperatures above 40°C, the structure disorders due to a reversible helix-coil transition. The structural and mechanical properties suggest a new route to synthetic peptide-based materials. - Source: PubMed
Publication date: 2026/09/11
Buvalaia EkaterinaDulle MartinDavid BenoitRengel KarolineOhl MichaelFörster BeateKruteva MargaritaHeise HenrikeBiehl RalfGohlke HolgerFörster Stephan - Immune checkpoint blockade (ICB) has revolutionized cancer treatment, yet its efficacy in gastrointestinal malignancies is often limited by an immunosuppressive tumor microenvironment. In this study, we identified phospholipase C beta 1 (PLCβ1) as a central driver of pathogenesis and ICB resistance in gastrointestinal cancer. Unlike classical oncogenes, PLCβ1 promoted tumor progression by fostering immune evasion rather than directly enhancing intrinsic tumor cell survival. Mechanistically, PLCβ1 interacted with ERC1, promoting its ubiquitin-proteasomal degradation. ERC1 destabilization suppressed NF-κB-dependent transcriptional activation of MHC-I, thereby impairing antigen presentation. Upstream, the YAP1 complex served as a direct transcriptional activator of PLCβ1, and pharmacological disruption of this pathway using the YAP inhibitor effectively restored MHC-I expression. Expression PLCβ1 was associated with reduced responsiveness to immunotherapy in patients, and combining the YAP inhibitor with anti-PD-1 therapy elicited synergistic antitumor responses in both syngeneic mice and patient-derived xenografts. Collectively, these findings uncover the YAP1-PLCβ1-MHC-I axis as a critical mechanism of immune escape and propose combinatorial YAP inhibition as a promising strategy to sensitize gastrointestinal tumors to immunotherapy. - Source: PubMed
Publication date: 2026/08/21
Zhang YingjingSu PengfeiYu TianHou BowenGao JianpengLiu FenglinHuang Yakai - Off-axis electron holography enables a direct access to electrostatic potentials in semiconductor heterostructures, but its quantitative interpretation relies critically on accurate mean inner potential (MIP) values. Here, we combine off-axis electron holography with self-consistent electrostatic simulations to extract the MIP of InxGa1-xN/GaN heterostructures. By calibrating the surface Fermi-level pinning, experimental phase-shift profiles are quantitatively matched to simulations, allowing the MIP difference between GaN and InxGa1-xN to be determined. The derived MIP values deviate systematically from the linear interpolation of unstrained MIP values of GaN and InN, indicating a significant strain contribution. This strain effect is captured by an analytical strain-dependent model that reproduces the experimental MIP trend and yields a large intrinsic difference between the unstrained MIP values of GaN and InN of 3.0±1.7 V, which is consistent with density functional theory calculations. The approach provides a practical and computationally efficient route for determining strain-dependent MIP values, facilitating quantitative electron microscopy studies of strained semiconductor heterostructures. - Source: PubMed
Lan QianqianSchnedler MichaelRosenzweig Dorothee SCarlin Jean-FrançoisButté RaphaëlGrandjean NicolasDunin-Borkowski Rafal EEbert Philipp - Kadsura longipedunculata Finet et Gagnep. belongs to the Kadsura Kaempf.exJuss. Vaccinium of the family Magnoliaceae. It mainly distributes in regions such as Guangxi, Sichuan, Fujian and Yunnan of China. Commonly used as traditional Chinese medicine for anti-inflammation and analgesia, it has a long history in folk medicine. In recent years, research on the active components and pharmacological activities of K. longipedunculata Finet et Gagnep. has received extensive attention. Many studies have reported that lignans are the characteristic active components, among which the gomisin group of compounds has been frequently reported, including Gomisin A, G, N, and M2. Our previous research found that another such compound, Gomisin R, could significantly inhibit the secretion of inflammatory factors in LPS-induced RAW264.7 mononuclear macrophages and reduce the expression of NF-κB p65 protein. However, the anti-inflammatory signaling pathways and target sites of Gomisin R remain unclear. - Source: PubMed
Publication date: 2026/07/17
Lang QinRong SuYa ChengYouli TangDandan MoBinglan TangRilun Li - A compact structure model for the icosahedral phase CdYb is presented. The model is based on a higher-dimensional description and a cut-and-projection procedure to generate the atom distribution in 3D physical space. It strictly employs only spherical or elliptical occupation domains, ensuring a low number of parameters and low calculation cost. In the presented form the model has seven adjustable parameters. Despite its minimalistic setting, the model reproduces very well available experimental data, such as chemical composition, mass density and electron-density distribution, as well as the cluster structure in physical space. Nevertheless, the approximation of the occupation domains by spheres and ellipses evidently implies limitations in accuracy and universality. The model can be adapted for the description of other Tsai-type icosahedral phases. - Source: PubMed
Publication date: 2026/07/09
Feuerbacher M