Ask about this productRelated genes to: USP9Y antibody
- Gene:
- USP9Y NIH gene
- Name:
- ubiquitin specific peptidase 9 Y-linked
- Previous symbol:
- -
- Synonyms:
- DFFRY
- Chromosome:
- Yq11.221
- Locus Type:
- gene with protein product
- Date approved:
- 1999-02-01
- Date modifiied:
- 2018-04-26
Related products to: USP9Y antibody
Related articles to: USP9Y antibody
- Sexual differences in embryos and fetuses are traditionally attributed to the development of the reproductive system and the production of sex hormones. In this study, the sex of Piau pig conceptuses (25-day embryos and 35-day fetuses) was determined using RNA-seq data through the detection of Y chromosome-linked transcripts. After quality control, 17 conceptuses were analyzed (8 embryos and 9 fetuses). Sex classification was based on the sum of counts per million (ΣCPM ) of twelve candidate genes, with thresholds above 200 for males and below 2 for females, wich allowed consistent separation between sexes. Among the identified transcripts, five genes (LOC102162178, ENSSSCG00000025253, USP9Y, LOC110257938, and ENSSSCG00000047835) are reported for the first time in association with sex determination in pigs. Network analysis revealed regulatory associations between these transcripts and transcription factors involved in gonadal development, including SRY, SOX9, and NOBOX. This study demonstrates that RNA-seq enables sex identification at early stages of swine development and reveals novel Y chromosome-linked transcripts in the Piau breed and their potential regulatory associations during swine sexual differentiation. - Source: PubMed
Publication date: 2026/04/04
Martins Tânia FernandesTeixeira Susana AmaralVerardo Lucas LimaGuimarães José DomingosGuimarães Simone Eliza Facioni - The study investigates how sex and age influence treatment response in paediatric, adolescent and young adult (AYA) classical Hodgkin lymphoma (cHL), integrating clinical data, immune-gene profiling and metabolic imaging from the European Network for Paediatric Hodgkin Lymphoma (EuroNet-PHL-C2 trial). cHL patients treated in Italian Association of Pediatric Hematology & Oncology Research (AIEOP) centres (2018-2020) underwent fluorodeoxyglucose-positron emission tomography (FDG-PET) at baseline, after two chemotherapy cycles early response assessment (ERA) and post-chemotherapy (late response assessment, LRA). Responses were classified as early complete metabolic response (CMR) or as adequate response (AR), inadequate (IR) or progressive disease at LRA. Tumour samples were profiled for 730 immune-related genes, and clinical and quantitative positron emission tomography parameters were integrated to assess sex- and age-related patterns. Sixty-eight cases passed quality control. Early CMR occurred in 51.5% at ERA; 29.4% showed (AR) at LRA. Older age (≥13 years), especially in males, was associated with higher IR risk. runt-related transcription factor 3 (RUNX3) expression characterized CMR; a five-gene panel (Bone Marrow Stromal Cell Antigen-1/CD157 [BST1]; C-X-C Motif Chemokine Receptor 6 [CXCR6]; Inducible T-cell Co-stimulator/CD278 [ICOS], Ubiquitin Specific Peptidase 9 Y-Linked [USP9Y], and Single Ig IL-1-Related Receptor/IL-1R8 [SIGIRR]) predicted IR and reflected sex-related immune differences. USP9Y expression correlated with baseline tumour volume (total metabolic tumour volume, TMTV1). Combining TMTV1 with RUNX3 improved CMR discrimination, while TMTV1 with the five-gene panel increased sensitivity but reduced accuracy at LRA. Sex and age influence immune response in AYA cHL. RUNX3 and the five-gene panel show promise as biomarkers of early and late response. - Source: PubMed
Publication date: 2026/03/12
De Re ValliLopci EgestaBrisotto GiuliaElia CaterinaVitullo AngeloPaduano VeronicaDe Zorzi MariangelaMussolin LaraQuarello PaolaBianchi SimonaBuffardi SalvatoreGaraventa AlbertoMuggeo PaolaPillon MartaSala AlessandraVinti Lucianad'Amore EmanueleMauz-Korholz ChristineMascarin Maurizio - Sexual dimorphism (SDM) is regulated by sex chromosomes, yet the specific contribution of individual genes remains unclear. To address this, we conducted a comprehensive phenotyping analysis to investigate the roles of Y chromosome-linked genes in SDM formation in mice. Using C57BL/6J mice, we identified 49 SDM traits across 14 biological systems. To assess gene-specific effects, we generated knockout (KO) mice for 10 unique Y-linked genes using CRISPR/Cas9. As expected, Sry KO resulted in feminization of most SDM traits, including gonadal sex. However, certain body size-related traits remained male-like, suggesting the involvement of additional Y-linked genes. Consistently, KOs of Uty and Usp9y significantly altered traits related to body and organ size. We further applied a dimensionality reduction approach to quantitatively capture SDM variation at the individual level, enabling visualization of phenotypic shifts in each KO mouse. Our findings demonstrate that non-Sry Y-linked genes contribute to SDM and introduce a generalizable framework for quantifying sex differences across individuals and species. - Source: PubMed
Publication date: 2026/01/06
Tanaka NobuhikoMiura KentoOzaki AiKozawa YasuyoTamura MasaruOgura AtsuoMatoba Shogo - Sika deer (), a species mainly distributed in the northeast of Asia, hold significant economic value in China due to their contributions to traditional Chinese medicine. A systematic investigation of their genetic structure is needed for population management. In this study, mitochondrial genome and AMELY, DBY, USP9Y, and SRY gene fragments on Y chromosome were used to elucidate the genetic structure of 303 individuals across 8 distinct populations. The mitosome analysis identified 72 haplotypes, with a haplotype diversity (Hd) of 0.917 and nucleotide diversity (π) of 0.0143, respectively. Meanwhile, 13 haplotypes were defined by Y chromosome genes with a Hd of 0.791. Analysis of the mitochondrial control region (CR) revealed subspecies-specific patterns of tandem repeat unit organization between continental and Japanese groups. Y chromosome analyses demonstrated a homogeneous paternal lineage across Japanese populations. - Source: PubMed
Publication date: 2025/10/17
Wang TianjiaoDong YimengWang LeiLiu HuamiaoSu WeilinXing Xiumei - Obesity is a well-known risk factor for developing obstructive sleep apnea (OSA) in children. Both OSA and obesity are independently associated with cardiovascular and metabolic comorbidities. These comorbidities are driven by shared pathophysiological pathways, making it difficult to distinguish the individual contributions of obesity and OSA. This study aimed to investigate the molecular mechanisms of OSA in children with obesity through whole blood mRNA sequencing. - Source: PubMed
Publication date: 2025/09/14
Affaticati FabioVermeiren ElineMeysman PieterBartholomeus EstherVan Hoorenbeeck KimOgunjimi BensonVerhulst StijnVan Eyck Annelies