Ask about this productRelated genes to: TIMP3 antibody
- Gene:
- TIMP3 NIH gene
- Name:
- TIMP metallopeptidase inhibitor 3
- Previous symbol:
- SFD
- Synonyms:
- -
- Chromosome:
- 22q12.3
- Locus Type:
- gene with protein product
- Date approved:
- 1993-04-12
- Date modifiied:
- 2014-11-19
Related products to: TIMP3 antibody
Related articles to: TIMP3 antibody
- Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) regulate extracellular matrix remodeling and contribute to the pathogenesis of coronary artery disease (CAD). This study examined the associations between MMP-2, MMP-9, and TIMP-3 and coronary atherosclerotic burden and cardiac function among smokers and non-smokers across the CAD spectrum. A total of 180 male participants were enrolled and divided into six groups ( = 30 per group): acute coronary syndrome (ACS) smokers, ACS non-smokers, chronic coronary syndrome (CCS) smokers, CCS non-smokers, control smokers, and control non-smokers. Serum MMP-2, MMP-9, and TIMP-3 levels were measured using ELISA. Coronary artery plaque severity was assessed using the Gensini score, while cardiac function was evaluated by echocardiography. MMP-9 and TIMP-3 levels were significantly higher in CCS patients than in controls, regardless of smoking status. MMP-9 showed significant positive correlations with the Gensini score in smokers ( = 0.556, < 0.001) and non-smokers ( = 0.596, < 0.001) and remained independently associated with coronary plaque severity in both groups. TIMP-3 was independently associated with the Gensini score only in non-smokers (B = 0.667, = 0.031). Higher MMP-9 levels were independently associated with reduced left ventricular ejection fraction and adverse diastolic parameters. Overall, MMP-9 was independently associated with coronary atherosclerotic burden and cardiac dysfunction, supporting its potential as a biomarker of CAD severity. ACS, rather than smoking status, appeared to have a greater influence on cardiac dysfunction. - Source: PubMed
Publication date: 2026/08/03
Aminuddin AmiliaSamah NazirahNor Faridah MohdWan Razali Wan Mohammad HafizCong Beh BoonMohamad Shawal FaizalHamid Adila ANorhisham Wafi KhadijahUgusman Azizah - Age-related macular degeneration (AMD) remains the leading cause of irreversible blindness in Western populations, with no approved therapies for the dry form characterized by drusen accumulation and retinal pigment epithelium atrophy. This review examines extracellular matrix alterations in Bruch's membrane by comparing healthy aging, AMD pathogenesis, and Doyne Honeycomb Retinal Dystrophy-a monogenic disorder that serves as a surrogate model for AMD due to similar phenotypic manifestations. - Source: PubMed
Publication date: 2026/06/16
Ehrenzeller ClaraMacLaren Robert E - Ovarian cancer remains the most lethal gynecologic cancer, with limited improvements in patient survival despite targeted therapies and a high recurrence rate (~80%). Current standard-of-care for frontline treatment involves platinum-based chemotherapy, but the emergence of resistant clones limits long-term efficacy. Existing models often overlook critical interactions between cancer cells and their microenvironment. Therefore, we investigated the ovarian cancer microenvironment to identify cell populations and markers driving treatment resistance. - Source: PubMed
Publication date: 2026/07/22
Del Pino Herrera AdrianaMartinez Miguel AKim MonicaEl-Bakkouri KadinIglesias David AFerrall-Fairbanks Meghan C - This study investigated the role of Krüppel-like factor 4 (KLF4) in macrophage-mediated inflammation in type 2 diabetes mellitus (T2DM) with psoriasis. KLF4, tissue inhibitor of metalloproteinases 3 (TIMP3), and a disintegrin and a metalloproteinase domain 17 (ADAM17) levels were measured in skin samples from patients. A diabetic psoriasis-like dermatitis mouse model was established using imiquimod (IMQ) and treated with KLF4-overexpressing lentiviruses. Glucose/lipid metabolism, skin pathology, mast cell counts, and inflammatory markers were assessed. Macrophage status was evaluated by F4/80 staining. KLF4 was downregulated in patients with T2DM with psoriasis. In mice with diabetic psoriasis-like dermatitis. KLF4 overexpression improved glucose/lipid metabolism and reduced skin erythema, scaling, thickening, psoriasis area severity index scores, and mast cell infiltration. KLF4 also decreased inflammation and modulated the TIMP3/ADAM17 pathway. These findings indicate that KLF4 ameliorates IMQ-induced inflammation via the TIMP3/ADAM17 pathway in diabetic psoriasis-like dermatitis. - Source: PubMed
Publication date: 2026/07/31
Jin MeichenLi YiyaoKong YuanCheng XiangyiZhang Jingbin - Endothelial cells play a crucial role in tumor invasion and metastasis. This study explored endothelial cell-targeted therapies for ovarian cancer (OC). - Source: PubMed
Publication date: 2026/07/24
Li ZongtaoXia JianmeiWang HaixiaLi ZhaoXiong JianZhao NaHuang Rui