Ask about this productRelated genes to: TIMP3 antibody
- Gene:
- TIMP3 NIH gene
- Name:
- TIMP metallopeptidase inhibitor 3
- Previous symbol:
- SFD
- Synonyms:
- -
- Chromosome:
- 22q12.3
- Locus Type:
- gene with protein product
- Date approved:
- 1993-04-12
- Date modifiied:
- 2014-11-19
Related products to: TIMP3 antibody
Related articles to: TIMP3 antibody
- Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease characterized by aberrant fibroblast activation and excessive extracellular matrix accumulation, predominantly collagen, leading to irreversible lung remodeling. Sinigrin (SNG), a naturally occurring glucosinolate with reported anti-inflammatory and antioxidant activities, has not been investigated in the context of pulmonary fibrosis. In the present study, we evaluated the therapeutic activity of SNG using complementary and models of IPF. In the current investigation, inflammatory responses were induced by lipopolysaccharide (LPS) in RAW 264.7 macrophages and precision-cut lung slices (PCLS), whereas fibrotic activation was elicited by TGF-β in LL29, DHLF cells, and PCLS. Treatment with sinigrin and dexamethasone significantly suppressed LPS-induced inflammatory mediators (IL-6, TNF-α, IL-1β, CCL2, MMP-9, and COX-2). In TGF-β-stimulated fibroblasts/PCLS, SNG and pirfenidone markedly attenuated collagen accumulation and downregulated the expression of key fibrotic markers (FN-1, α-SMA, TIMP-1, TIMP-3, COL1α1, and COL3α1). SNG administration in a bleomycin-induced pulmonary fibrosis mouse model significantly improved body weight, survival rate, and pulmonary index. Histopathological analyses revealed reduced collagen deposition and lowered Ashcroft scores, accompanied by decreased oxidative stress and improved lung function in SNG treatment compared to BLM and PFD groups. Consistently, gene and protein expression analyses demonstrated that SNG dose-dependently attenuated the bleomycin-induced inflammatory and fibrotic marker expression. Further mechanistic investigations, including an AMPK siRNA-based approach, demonstrated that SNG exerts its anti-inflammatory and antifibrotic effects partly through activation of AMPK signaling. Collectively, these findings suggest that SNG may represent a therapeutic candidate for the treatment of IPF. - Source: PubMed
Publication date: 2026/08/12
Panneerselvam SuriyaS JeyasankariKishore AnoopAndugulapati Sai Balaji - Standardized molecular methods to assess the host response to breast implants are lacking. Mass spectrometry-based proteomics offers an unbiased approach to characterize the capsule proteome and the foreign-body response. - Source: PubMed
Publication date: 2026/09/10
Larsen AndreasØstergaard OleWeltz Tim KongsmarkTran John Vinh QuangBak Erik Eiler FrydshouGuðjónsdóttir Linda RegínaHemmingsen Mathilde NejrupØrholt MathiasVester-Glowinski PeterWoetmann AndersOlsen Jesper VelgaardHerly Mikkel - Stromal cells are known to play critical roles in the development and progression of solid tumors including lung cancers. This study was proposed to clarify the biological features of stromal cells from intratumoral, peritumoral lung, and distal lung tissues of primary lung adenocarcinoma patients. - Source: PubMed
Publication date: 2026/09/07
Kamimura GoAoki MasayaLi Tao-ShengFurukawa TatsuhikoYamamoto MasatatsuIshihara YukaKawahara KohichiUeda Kazuhiro - Gliomas, particularly glioblastoma, remain difficult to control because diffuse infiltration into surrounding brain tissue limits complete resection and contributes to recurrence. Cannabidiol (CBD), a nonpsychoactive cannabinoid capable of entering the central nervous system, has shown antitumor activity in glioma models, but the mechanisms underlying its anti-invasive effects remain unclear. Lysyl oxidase-like 2 (LOXL2) regulates extracellular-matrix remodeling and mesenchymal phenotypes in several cancers. We therefore tested the hypothesis that CBD limits glioma growth and invasion partly by suppressing an LOXL2-associated extracellular-matrix and EMT-like program. - Source: PubMed
Guan LeiDeng XuyanZheng JingYang ZejiJiang XiaoxiaWang Yan - This study aims to systematically elucidate the shared and specific genetic basis of osteoarthritis (OA) and obesity by integrating large-scale genome-wide association study (GWAS) summary statistics, cross-tissue quantitative trait loci (QTLs), and single-cell and spatial transcriptomic data. - Source: PubMed
Publication date: 2026/08/13
Lin ZehongWei JihuZhou Honghai