Ask about this productRelated genes to: TIMP2 antibody
- Gene:
- TIMP2 NIH gene
- Name:
- TIMP metallopeptidase inhibitor 2
- Previous symbol:
- -
- Synonyms:
- CSC-21K
- Chromosome:
- 17q25.3
- Locus Type:
- gene with protein product
- Date approved:
- 1992-06-18
- Date modifiied:
- 2016-10-05
Related products to: TIMP2 antibody
Related articles to: TIMP2 antibody
- Diabetic retinopathy (DR) is a common comorbidity of diabetes involving the formation of abnormal vascular structures in the retina. Tissue inhibitor of metalloproteinases 2 (TIMP2), initially identified as a key mediator of extracellular matrix turnover, is pivotal for inflammatory processes and tissue homeostasis. The current study examined the influence of gene variations on the risk for DR. - Source: PubMed
Huang Chin-TeChien Hsiang-WenWang KaiSu Shih-ChiTing Chin-HanYang Shun-FaLiao Miao-Yu - Longstanding subclinical Crohn's Disease (CD) can progress to complications such as intestinal strictures and penetrating (intestinal fistulae, abscesses, or perforations) disease. Despite the advances in non-invasive diagnostics for IBD, there is a dearth of biomarkers for predicting disease progression and complications in CD. Here, we investigate four baseline stool biomarkers, BDNF, MMP-8, TIMP-2, and Calprotectin (S100A8/A9), for their ability to predict disease progression in pediatric CD. - Source: PubMed
Publication date: 2026/04/10
Polamarasetty HarshavardhanPereira RyanMaruvada VinaikaVanarsa KamalaWankhade DiptishYadavalli RajeshKugathasan SubraMohan Chandra - Feline oral and cutaneous squamous cell carcinoma (SCC) are aggressive neoplasms characterized by high local invasiveness. Given its spontaneous occurrence and molecular similarities, feline SCC represents a robust comparative model for human head and neck squamous cell carcinoma (HHNSCC). This pilot study aimed to characterize the expression of metalloproteinases (MMPs), their tissue inhibitors (TIMPs), and cytokeratin 10 (CK10) in relation to Papillomavirus (PV) status, and to explore the viral-molecular relationship in feline oncology. - Source: PubMed
Publication date: 2026/04/10
Tutu PaulAltamura GennaroDaraban Bocaneti FlorentinaHritcu Ozana MariaPasca Aurelian-SorinDascalu Mihaela AncaHorodincu LoredanaTanase Oana IrinaMares MihaiBorzacchiello Giuseppe - Bothrops envenomation induces extensive local tissue destruction and a robust inflammatory response, largely driven by the host's endogenous molecular pathways. Among these, Matrix Metalloproteinases (MMPs), zinc-dependent endopeptidases responsible for extracellular matrix (ECM) degradation, play a central role. The clinical severity of envenomation is therefore strongly influenced by the balance between MMPs and their specific inhibitors, the TIMPs. This study investigated the contribution of MMP-1, MMP-2, MMP-7, MMP-9, and MMP-10 and TIMP-1, TIMP-2, TIMP-3, and TIMP-4 to the inflammatory response following Bothrops snakebites. - Source: PubMed
Publication date: 2026/04/24
Ferreira Neves Juliana CostaMagalhães-Gama FábioIbiapina Hiochelson Najibe SantosSeixas Kamille BeltrãoBarbosa Êndila SouzaMalheiro AdrianaSachett Jacqueline Almeida GonçalvesCampi-Azevedo Ana CarolinaMartins-Filho Olindo AssisTeixeira-Carvalho AndréaSartim Marco AurélioMonteiro WueltonCosta Allyson Guimarães - Cast-induced acute kidney injury (AKI) is a frequent yet under-recognized cause of kidney dysfunction in the intensive care unit. It arises when filtered proteins or pigments - free light chains (FLCs) in multiple myeloma, myoglobin in rhabdomyolysis, bilirubin in severe cholestasis, or hemoglobin in intravascular hemolysis - precipitate within kidney tubules, forming obstructive casts and triggering oxidative and inflammatory injury. Early recognition is essential because traditional markers (creatinine, urine output) rise late. Emerging biomarkers, including neutrophil gelatinase-associated lipocalin (NGAL), cystatin C, and the tissue inhibitor of metalloproteinases-2 · insulin-like growth factor binding protein-7 ([TIMP-2]·[IGFBP7]) panel, detect tubular stress earlier and can guide timely intervention. This narrative review summarizes pathophysiology, diagnostic tools, and extracorporeal strategies tailored to the offending molecule and patient stability. For myeloma cast nephropathy, high cut-off membranes provide robust early FLC clearance but require albumin monitoring; medium cut-off and polymethylmethacrylate membranes offer sustained removal with lower albumin loss. In rhabdomyolysis, continuous kidney replacement therapy with high-flux or newer membranes supports hemodynamic stability and myoglobin clearance; hemoadsorption may be considered in severe cases. In bile cast nephropathy, artificial extracorporeal liver support (e.g., molecular adsorbent recirculating system, fractional plasma separation and adsorption), single-pass albumin dialysis, and hemoadsorption reduce bilirubin and bile acids, while plasma exchange remains reserved mainly for hyperviscosity syndromes. Across etiologies, extracorporeal approaches are most effective when combined with disease-specific treatments, such as chemotherapy for myeloma or targeted therapy for hemolysis. Emerging evidence suggests that integrating artificial intelligence-driven diagnostic tools with these therapeutic strategies may further enhance early recognition and individualized management of renal injury. A patient-centered, pathophysiology-driven strategy can shift extracorporeal therapies from rescue measures to proactive tools that improve kidney recovery and survival. Prospective studies should refine timing, modality selection, and biomarker-based algorithms to optimize outcomes in cast-induced AKI. - Source: PubMed
Publication date: 2025/12/04
De Rosa SilviaFerrari FiorenzaZarantonello DianaDalpiaz AlessiaLassola Sergio