Ask about this productRelated genes to: TIMP2 antibody
- Gene:
- TIMP2 NIH gene
- Name:
- TIMP metallopeptidase inhibitor 2
- Previous symbol:
- -
- Synonyms:
- CSC-21K
- Chromosome:
- 17q25.3
- Locus Type:
- gene with protein product
- Date approved:
- 1992-06-18
- Date modifiied:
- 2016-10-05
Related products to: TIMP2 antibody
Related articles to: TIMP2 antibody
- This study explores the therapeutic efficacy and mechanisms of panaxadiol (PD), a ginseng-derived sapogenin, in a mouse model of vascular cognitive impairmentinduced by chronic cerebral hypoperfusion (CCH). - Source: PubMed
Publication date: 2026/09/22
Bai XingyuMa YongxinWang ShuangQin HeJia HongboZhang MengChen SiyuXu Yaoming - Acute kidney injury (AKI) is common after lung transplantation (LUTX), with standard diagnostic criteria having limited early accuracy. We evaluated the AKI and postoperative outcomes risk-stratification performance of subclinical AKI and creatinine-independent kidney-injury phenotypes. - Source: PubMed
Publication date: 2026/09/02
Scaravilli VittorioUslenghi AlessandroTurconi GloriaColombo Sebastiano MariaBosone MarcoVago ValentinaCarrà Davide PietroBrivio MargheritaMorlacchi Letizia CorinnaCastellano GiuseppeZanella AlbertoNosotti MarioRosso LorenzoBlasi FrancescoGrasselli Giacomo - - Source: PubMed
Zhang HuaZhang JidongMeng FanruiZhu HanzhongYan HongyuGuo YunliangZhang Shandi - Occupational heatstroke frequently causes acute kidney injury (AKI). Myoglobin, released by exertional rhabdomyolysis, is the central nephrotoxic amplifier and may be physically removable by extracorporeal techniques. Yet the trials governing purification timing enrolled general intensive care populations whose injury biology differs. We aimed to integrate heatstroke-specific renal pathophysiology, novel AKI biomarker performance, and evidence on extracorporeal modalities. We then mapped the temporal cascade onto a biomarker-augmented framework for initiating blood purification during a narrative State-of-the-Art Review. Ten search blocks were run in PubMed/MEDLINE to 16 August 2026, yielding 16,443 unique records. Eligible sources reported human or animal data, consensus statements, or mechanistic evidence bearing on three questions: (i) how does heat injure kidneys? (ii) which biomarkers detect injury? and (iii) when blood purification should begin? Records without an English-language abstract or without retrievable full text were excluded and, ultimately, 95 discreate sources were retained. Four pathways operate on distinct timescales: direct thermal cytotoxicity, myoglobin-driven ferroptosis, inflammatory-coagulation amplification, and gut-derived endotoxemia. L-FABP has the only prospective heat-specific human data; [TIMP-2]·[IGFBP7] has the strongest critical care record but none in heatstroke. No biomarker is validated for predicting later chronic kidney disease in this population. No modality has been shown superior in a heatstroke-specific population, and only one clinical study reports outcomes in exertional heatstroke. We propose a provisional three-tier initiation framework anchored to myoglobin concentration and tubular injury biomarkers rather than creatinine alone. It is a structured hypothesis rather than validated guidance, and prospective biomarker-stratified trials in occupational settings are needed. - Source: PubMed
Publication date: 2026/09/14
Wang Sisi - Matrix metalloproteinases (MMPs) regulate extracellular matrix remodeling and are implicated in neurodegeneration and brain ageing. Tissue inhibitor of metalloproteinase-2 (TIMP2) has been associated with hippocampal plasticity and cognitive function. We investigated whether cerebrospinal fluid (CSF) TIMP2 levels and genetic variants are associated with clinical features in Parkinson's disease (PD) and its continuum with dementia with Lewy bodies (DLB), with a particular focus on ageing-related processes. - Source: PubMed
Publication date: 2026/09/12
Zimmermann MilanFandrich MadeleineSchulte ClaudiaJakobi MeikeWurster IsabelLerche StefanieZimmermann ShahrzadDeuschle ChristianSchneiderhan-Marra NicoleJoos Thomas OGasser ThomasBrockmann KathrinRoeben Benjamin