Ask about this productRelated genes to: TLR8 antibody
- Gene:
- TLR8 NIH gene
- Name:
- toll like receptor 8
- Previous symbol:
- -
- Synonyms:
- CD288
- Chromosome:
- Xp22.2
- Locus Type:
- gene with protein product
- Date approved:
- 2001-04-27
- Date modifiied:
- 2016-10-05
Related products to: TLR8 antibody
Related articles to: TLR8 antibody
- Toll-like receptor 7 (TLR7) and TLR8 respond to pathogen-derived single-stranded RNA (ssRNA), orchestrating innate immune defense responses upon infections. However, aberrant recognition of endogenous ssRNAs by these sensors can cause various pathologies, including systemic lupus erythematosus (SLE), familial histiocytosis, immunodeficiency, and bone marrow failure. Recent insights into genetic variations in TLR7/8 and functionally associated genes have elucidated the mechanisms that prevent excessive TLR7/8 activation. Specifically, TLR7/8 responses are negatively regulated by several mechanisms, including the TLR-specific chaperone UNC93B1, lysosomal NADPH oxidase NOX2, the lysosomal nuclease PLD4, and the lysosomal nucleoside transporter SLC29A3. Given the link between dysregulated TLR7/8 activation and diseases development, therapeutic agents targeting these receptors are currently under clinical trials to evaluate their efficacy in treating SLE. - Source: PubMed
Publication date: 2026/10/03
Fukui RyutaroMiyake Kensuke - Hepatitis C is one of the leading causes of acute and chronic hepatitis worldwide. Immunoinformatics has emerged as a reliable and practical approach for identifying immunogenic regions. We analyzed the HCV genotype 3a polyprotein for antigenicity, allergenicity, and physicochemical characteristics. Four vaccine constructs with possible immunogenic qualities were assembled. B-cell epitopes were examined to predict antigenic determinants, and T-cell epitopes were assessed for MHC class I and II binding. All were linked together using linker peptides, a reliable adjuvant, the PADRE sequence, and a His tag. All models were analyzed for structural refinement, population coverage, molecular docking, molecular dynamics, and immune simulation. The vaccine constructs exhibited antigenicity > 0.6 in E. coli, solubility > 0.8, and GRAVY values between - 0.124 and - 0.518, indicating a hydrophilic nature. The Ramachandran plot showed that 90% of residues were within the allowed regions, confirming structural stability. The vaccine constructs showed more than 99% global coverage and 97% coverage for the Pakistani population. Docking analysis showed strong binding of the Vaccine2-TLR8 and Vaccine4-TLR3 complexes, with docking energies of - 1153.5 kcal/mol and - 1015.8 kcal/mol, respectively. Molecular dynamics simulations revealed a stabilized and consistent complex of TLRs. A strong humoral response was predicted by recording IgG and IgM titers within 5 days, which remained for 35 days. In silico cloning showed successful insertion into the pET-29a ( +) vector. These results indicate that multiple-epitope vaccine constructs have strong binding properties and are good candidates for developing a vaccine against HCV3a. - Source: PubMed
Publication date: 2026/10/03
Kalsoom AasiaAleem ZahraRehman Hafiz MuzzammelSajjad MuhammadShabbir GhulamKhan Muhammad ShakilAltaf AwaisRahman Inam UrAlharbi MetabAlasmari Abdullah F - Idiopathic multicentric Castleman disease (iMCD) is a heterogeneous cytokine storm disorder involving systemic inflammation, multicentric lymphadenopathy with characteristic histopathology, and life-threatening multiple organ dysfunction. Patients can present with symptoms ranging from thrombocytopenia, anasarca, fever/elevated C-reactive protein (CRP), reticulin myelofibrosis, renal dysfunction, and organomegaly (iMCD-TAFRO) to thrombocytosis, hypergammaglobulinemia, and plasmacytosis (iMCD-IPL), with patients not falling into either group (iMCD-NOS). The molecular mechanisms across the clinical subtypes have not been elucidated and new effective treatments are needed. Here, we performed bulk RNA sequencing and targeted gene expression quantification in lymph node tissue from multiple iMCD clinical subtypes, pathologically related disorders, and controls. We identified 249 upregulated and 42 downregulated genes in iMCD-TAFRO lymph node tissue, which were enriched in the following pathways: angiogenesis, cell proliferation, and various aspects of the humoral and innate immune response. The targeted gene expression analysis revealed shared differentially expressed genes (DEGs) across all three iMCD clinical subtypes, including , , , and . We identified unique DEGs in each iMCD clinical subtype, including (iMCD-TAFRO), (iMCD-IPL), and (iMCD-NOS). Since Clusterin () was significantly upregulated in iMCD but not in related conditions, we performed immunohistochemistry and observed that Clusterin is elevated in the germinal center and mantle zone regions of iMCD patient lymph nodes. A composite model incorporating CLU expression in these lymph node compartments with germinal center features demonstrated strong performance in differentiating iMCD from selected lymphadenopathies. Together, this work identified pathways dysregulated in iMCD lymph nodes and suggests that Clusterin, particularly when integrated with germinal center features, could be a novel biomarker. - Source: PubMed
Publication date: 2026/09/17
Gonzalez Michael VWang KaiwenZinski JosephMumau Melanie DForsyth Katherine SIrvine Abiola HBrandstadter JoshuaGuzman Stacy GZhang LuPierson Sheila KAustin BridgetFajgenbaum David C - Prolonged preoperative fasting is associated with intestinal dysbiosis, impaired mucosal homeostasis, and delayed postoperative recovery. Combined nutritional supplementation with glutamine, dietary fiber, and oligosaccharides has the potential to protect intestinal function during nutritional stress. In this study, we investigated the effects of this nutritional combination in a rat model of prolonged fasting. - Source: PubMed
Publication date: 2026/09/17
Murai YutaIwasawa TakumiTakeda SatoshiOhki KahoKato KazunoriIto Tomoaki - Sequential exposure to heterologous noxious stimuli such as histological chorioamnionitis (HCA) and hyperoxia may elicit variable immune responses, resulting in distinct disease manifestations in the neonate. However, the molecular mechanisms underlying innate immune dysregulation in these contexts remain poorly characterized. - Source: PubMed
Publication date: 2026/09/15
Sequeira Gomes RochelleGayen Nee' Betal SuhitaAddya SankarGayen SaurabhZubair NidaChan Joanna S YAghai Zubair H