Ask about this productRelated genes to: PCSK6 antibody
- Gene:
- PCSK6 NIH gene
- Name:
- proprotein convertase subtilisin/kexin type 6
- Previous symbol:
- PACE4
- Synonyms:
- SPC4
- Chromosome:
- 15q26
- Locus Type:
- gene with protein product
- Date approved:
- 1992-06-05
- Date modifiied:
- 2019-04-23
Related products to: PCSK6 antibody
Related articles to: PCSK6 antibody
- The arteriovenous fistula (AVF), the preferred vascular access for hemodialysis, is limited by neointimal hyperplasia. Although proprotein convertase subtilisin/kexin type 6 (PCSK6) is involved in vascular smooth muscle cell (VSMC) activation, its role in AVF stenosis is unclear. PCSK6 expression was significantly upregulated in VSMCs of human and murine stenotic AVFs and correlated with the severity of neointimal hyperplasia. , PCSK6 overexpression promoted VSMC proliferation, migration, contractility, and extracellular matrix (ECM) synthesis, whereas PCSK6 knockdown suppressed these processes. Mechanistically, PCSK6 directly interacted with STAT1 and enhanced its phosphorylation, with STAT1 inhibition reversing PCSK6-driven effects. , smooth muscle cell-specific PCSK6 knockout in mice on a high-glucose diet attenuated neointimal formation, improved AVF lumen diameter and blood flow, and enhanced vasodilation. In conclusion, PCSK6 drives AVF neointimal hyperplasia by binding and activating STAT1 to promote VSMC phenotypic switching and ECM remodeling, identifying the PCSK6/STAT1 axis as a novel mechanism and potential therapeutic target for preventing AVF failure. - Source: PubMed
Publication date: 2026/05/05
Guo XiangjiangCao RuzhouWang TianchenZhang LanLi Yinan - - Source: PubMed
Publication date: 2026/04/20
Berger KristinKonkol SamMa Shwu-FanWhalen WilliamSimmons WillJoseph ChitraNoth ImreHuang YongOldham JustinMoskaluk Christopher ALynch DavidHumphries StephenKim John SPodolanczuk Anna J - Esophageal cancer (EC) is a highly aggressive malignancy associated with high rates of recurrence and metastasis, and the five-year survival rate remains only 20-30%. N6-methyladenosine (m6A), the most abundant mRNA modification, plays a pivotal role in regulating gene expression and disease pathogenesis. As an m6A "reader," heterogeneous nuclear ribonucleoprotein C (HNRNPC) binds RNA through its recognition motif and has been shown to contribute to the progression of several cancers, including colorectal, breast, and non-small cell lung cancer. However, its function and mechanism in EC remain unclear. In this study, we demonstrated that HNRNPC was upregulated in EC and correlated with poor prognosis, based on analyses of public databases and a clinical cohort. Using the xenograft mouse model, we found that HNRNPC knockdown suppressed EC tumor growth in vivo. Interestingly, mechanistic studies revealed that HNRNPC depletion promoted cell apoptosis without affecting proliferation, thereby inhibiting tumor growth. At the molecular level, HNRNPC deficiency selectively influenced transcripts with complex structures, such as CD44, OLFML2A, and PCSK6, and subsequently disrupted extracellular matrix-receptor interactions, leading to impeded tumor progression. - Source: PubMed
Publication date: 2026/04/17
Ding GangfengHe JiayaoChen YichaoLiu LeiHe QiaqiaLi Lili - Carcinoma-associated fibroblasts (CAFs) are core components of the tumor microenvironment, which contribute to tumor initiation and progression through mediating immune suppression. In this study, eight activated CAF subpopulations were identified by single-cell sequencing (scRNA-seq). A specific subtype of CAFs, characterized by PCSK6 expression, strengthened PD-L1 membrane distribution, which contributed to the cytotoxic CD8T cells exhaustion, subsequently promoting the progression of colorectal cancer (CRC). PCSK6 interacting with ACVR1B on CRC cell surface, promoting the acetylation modification of PD-L1 via acetyltransferase p300, followed by strengthened PD-L1 membrane distribution. Loss of PCSK6/ACVR1B signaling in tumor stroma enhanced the intratumoral infiltration and activation of CD8T cells, alleviated growth of CRC and conferred survival advantage in tumor-bearing mice. Moreover, the membrane level of PD-L1 was mediated by the membrane transport complex Rab8/EHBP1L1. Our finding suggested PCSK6/ACVR1B-p300-Rab8/EHBP1L1-PD-L1 signaling axis is significantly activated by CAFs-derived PCSK6, which may offer mechanism interpretation for CAFs mediated CRC immune escape and suggest potential mechanism-based therapeutic strategies for ACVR1B antagonist. - Source: PubMed
Publication date: 2026/04/13
Du QianmingFei YuxiangLi TaoWang DejuHu ShengYang YaTang WenlianZhang XuDiao HongtingLiu Chao - In heart failure with preserved ejection fraction (HFpEF), fluid volume overload constitutes a critical factor driving disease progression. Mahuang decoction (MHD), a traditional Chinese medicine with diaphoretic and diuretic properties, has shown potential in improving HFpEF, yet its mechanisms remain unclear. - Source: PubMed
Publication date: 2026/03/21
Liang XiaoyuChen ZiyiHao XiaopengLiu SiyuLiu YongchengWei YueZhang YuanchangLiu YinongDong GuojuHuang Luqi