Ask about this productRelated genes to: Mapk10 antibody
- Gene:
- MAPK10 NIH gene
- Name:
- mitogen-activated protein kinase 10
- Previous symbol:
- PRKM10
- Synonyms:
- JNK3, p493F12, p54bSAPK
- Chromosome:
- 4q21.3
- Locus Type:
- gene with protein product
- Date approved:
- 1998-04-28
- Date modifiied:
- 2016-10-05
Related products to: Mapk10 antibody
Related articles to: Mapk10 antibody
- Peutz-Jeghers syndrome (PJS) is a rare inherited cancer predisposing disorder associated with pathogenic variants of the Serine Threonine Kinase11 (STK11 / LKB1). Morbidity in children is driven by small intestinal obstruction from polyps. The molecular mechanisms driving polyp initiation and growth are poorly understood. We hypothesized that integrated phosphoproteomic analysis of pediatric Peutz-Jeghers polyps would reveal signaling networks driving polyp growth. - Source: PubMed
Publication date: 2026/05/04
Pushel IrinaRoy Badal CNolte Whitney MHarvey LisaBagherian AmberRekowski Michaella JClark Zachary DWashburn Michael PUmar ShahidAttard Thomas M - As a pivotal secondary metabolite of Aspergillus fumigatus, gliotoxin (GT) has many toxicological effects on mammalian cells; however, its function on LC3-associated phagocytosis (LAP) induced by A. fumigatus in macrophages is poorly understood. Here, it was found that pretreatment of macrophages with GT can significantly attenuate the conversion of LC3-II. In parallel, the expression of Rubicon, the putative indicator of LAP in macrophages, was dampened in a similar trend. Loss of ability to produce GT made the conidia of gliPΔ mutant of A. fumigatus induce more LC3-II conversion in THP1 cells, which could be inhibited by exogenous GT. Comparative transcriptomic analysis showed that GT can promote the expression of MAPK10, and the calcium-release regulatory pathway was enriched between the differentially expressed genes. Further, GT promotes the release of ROS at a concentration of 50 ng/mL, and inhibition by GT on LC3-II production in macrophages during A. fumigatus infection could be restored by pretreatment with calcium inhibitors but not affected by the inhibitors for JNK and siRNA for MAKP10. Collectively, our data demonstrated that GT exerts an inhibitory effect on LC3-associated phagocytosis in macrophages via a calcium-dependent mechanism, and MAPK10 exists downstream of LAP. - Source: PubMed
Sun YuqingChen FangyanZhang LingZheng CaopeiWang YuZhang YulinHan Li - Polygonati Rhizoma has been reported to exhibit the ability to retard skin aging. However, the precise molecular mechanisms underlying remain largely elusive. In this study, we screened 9 active compounds in Polygonati Rhizoma using the TCMSP and SwissADME databases. Subsequently, 285 potential targets were identified via Swiss Target Prediction Database. Concurrently, 800 genes related to skin aging were retrieved from GeneCards, OMIM, and TTD databases. By intersecting these datasets with the potential targets of Polygonati Rhizoma, we pinpointed 17 overlapping genes. These genes were further subjected to GO function annotation and KEGG pathway analysis using DAVID database. A compound-target-pathway network was then constructed using Cytoscape software, highlighting two compounds (4',5-dihydroxyflavone and baicalein) and six targets (MAPK1, MAPK10, MMP9, PTGS2, PDGFRB, and CYP1B1). Molecular docking revealed that the binding energy between 4',5-dihydroxyflavone and baicalein with the six targets was less than - 5 kcal/mol, particularly for MMP9, PTGS2, and CYP1B1, indicating a stable interaction. The molecular dynamic simulations demonstrate that both ligands form stable complexes with MMP9 and PTGS2. Finally, the antioxidant capacity of 4'5-dihydroxyflavone and baicalein was evaluated in vitro, confirming significant antioxidant activity. Collectively, our findings provide a systematic foundation for elucidating the molecular mechanisms underlying the anti-aging effects of Polygonati Rhizoma and offer valuable insights into the development of anti-skin aging cosmetics. - Source: PubMed
Publication date: 2026/04/10
Wang XilongLei QinzhenCai FenqiangLuo XiaoyanDuo Xinyuan - Ventral midbrain dopaminergic neurons are a key cell type for schizophrenia pathophysiology but information about cell type-specific genomic dysregulation in diseased brains is missing. We generated a unique midbrain functional genomics resource with 97 RNA-seq and 34 Hi-C chromosomal contact libraries for Nurr1 + /NeuN+ dopaminergic and their surrounding Nurr1-/NeuN- nuclei, collected from donors diagnosed with schizophrenia (SCZ), bipolar disorder (BD) and compared to neurotypical controls. Among the 954 dopamine neuron genes specifically dysregulated in SCZ, 331 were downregulated, with selective enrichment for risk-associated synaptic plasticity and neuronal connectivity pathways and embedded within dopamine neuron-specific topologically associated chromosomal domains (TAD). Transcript-resolved analysis revealed 2,350 transcripts with altered expression in SCZ dopamine neurons, affecting key susceptibility genes such as the FOXP1, MAPK10, PCM1 and NRXN1. Therefore, genomic dysregulation in the ventral midbrain of subjects diagnosed with SCZ selectively affects dopaminergic neurons, and includes a unilateral association of genetic risk with down-, but not upregulated transcription at the sites of highly organized chromosomal domains harboring neuron-specific genes with complex transcriptional architectures. - Source: PubMed
Publication date: 2026/04/06
Singh SwadhaIskhakova MarinaLambert Tova YValada AditiShokrian NedaEvans VivianaBendl JaroslavAuluck Pavan KMarenco StefanoWang MinghuiZhang BinHoffman Gabriel EGirdhar KiranRoussos PanosAkbarian Schahram - Co-infection with avian leukemia and Pullorum Disease severely compromises poultry health, yet its pathogenic mechanisms remain unclear. We employed transcriptome sequencing to analyze gene expression changes and enriched pathways in kidney, spleen, and liver tissues of Chongqing Chengkou mountain chickens under single-infection (avian leukemia virus or Pullorum Disease) and co-infection conditions. Significant differences were observed in the number and pathways of differentially expressed genes between co-infected and single-infected groups. These genes were predominantly enriched in pathways involving extracellular matrix-receptor interactions, PPAR signaling, and calcium ion signaling. RT-qPCR validation confirmed significant upregulation of MAPK10 and SQLE, alongside downregulation of genes such as FOXG1. This study identifies multiple differentially expressed genes and pathways associated with immunity and tumorigenesis, providing crucial molecular insights into the regulatory mechanisms underlying avian leukemia and Pullorum Disease co-infection. - Source: PubMed
Publication date: 2026/03/18
Tan MinRan RongLiu ChengXie TaoZhang KeshanWang QiguiLan XiWang Haiwei