Ask about this productRelated genes to: Mapk10 antibody
- Gene:
- MAPK10 NIH gene
- Name:
- mitogen-activated protein kinase 10
- Previous symbol:
- PRKM10
- Synonyms:
- JNK3, p493F12, p54bSAPK
- Chromosome:
- 4q21.3
- Locus Type:
- gene with protein product
- Date approved:
- 1998-04-28
- Date modifiied:
- 2016-10-05
Related products to: Mapk10 antibody
Related articles to: Mapk10 antibody
- Rumen development shows clear spatial specificity, with distinct tissue morphology and proliferation patterns across regions. This heterogeneity likely results from region-specific transcriptional regulation. Identifying key genes and signaling pathways underlying these spatial differences is helpful for understanding the molecular basis of rumen development. This study investigated the morphological characteristics of different rumen regions in lambs, analyzed their associations with growth performance and fermentation parameters, and explored the underlying transcriptomic profiles. Histological observations revealed pronounced regional variation in rumen morphology. The ventral sac exhibited longer and denser papillae and a thicker keratinized layer than the blind sacs. Correlation analysis showed that papilla length and density were positively associated with growth performance traits such as body weight and average daily gain. Transcriptomic analysis revealed the highest number of differentially expressed genes (DEGs) between the ventral and caudoventral blind sacs. Functional enrichment indicated that DEGs were enriched in focal adhesion, signaling, and cytoskeletal remodeling pathways. Members of the family and other keratinization-related genes, together with , , , and , may coordinately regulate these pathways, contributing to the region-specific development of the rumen ventral sac. In conclusion, this study demonstrates distinct morphological and transcriptional patterns among rumen compartments, highlighting the ventral sac as the principal site for volatile fatty acid absorption and epithelial renewal. These findings provide new insights into the spatial regulation and molecular basis of rumen compartmental development. - Source: PubMed
Publication date: 2026/08/03
Jia JialeXu YunfeiWang GuoxiuWang WeiminLi KaidongZhu AnfengZhao JingZhang YangLiu ZhenMiao ZichunLi Chong - This study aimed to identify candidate genes and genetic markers affecting milk production traits in dual-purpose cattle, providing a foundation of data for marker-assisted breeding. Cis-eQTL analysis was performed on 83 Xinjiang brown cattle and 80 Chinese Simmental cattle using whole-genome resequencing and RNA-seq data derived from blood samples. Candidate genes were prioritized by overlapping the eGenes with genes from previous selective signature analyses. In Xinjiang brown cattle, 293,758 cis-eQTLs regulating 1,720 genes were identified, whereas 78,735 cis-eQTLs regulating 569 genes were found in Chinese Simmental cattle. By overlapping the eGenes with candidate genes from previous selective signature analyses, we prioritized 103 genes (e.g., , and ) in Xinjiang brown cattle and 26 candidate genes (e.g., and ) in Chinese Simmental cattle as potentially related to milk production traits. These results provide valuable data for the development of new dairy lines in Xinjiang brown cattle and for future genomic selection in dairy-oriented Chinese Simmental cattle. - Source: PubMed
Publication date: 2026/07/21
Ma KailunLi XueZhang MenghuaWang DanMa ShengchaoHuang XixiaChen QiumingXu Lei - Alzheimer's disease (AD) is an aging-related neurodegenerative disease characterized by an initial memory impairment that progresses to a widespread cerebrocortical failure, culminating in death. Understanding the molecular mechanisms that protect brain function during aging may help reveal novel targets for the development of effective treatments for the memory and cognitive deficits associated with AD. In this study, we analyzed a gene expression dataset generated from the prefrontal cortices of individuals showing no neurological or cognitive abnormalities. The gene expression profiles were used to identify candidate protective genes. We then compared the expression patterns of these genes in aging with their expression patterns in AD, thereby enabling us to pinpoint the genes that potentially contribute to brain resilience that delays or prevents aging-related dementia. We selected seven genes that are potentially protective for aging and AD, and have known homologues in (). Among these genes, , , and were previously implicated in attenuating AD-related cognitive decline. Our experiments demonstrated that all seven genes prioritized by our resilience model significantly extended the lifespan of . Given the important relationship between neuronal functional integrity and lifespan (i.e., lifespan vs. brain health span), this work suggests the predicted AD resilience genes could serve as important candidate targets for therapeutic intervention. - Source: PubMed
Publication date: 2026/07/06
Guo LeiGrimaldi NicholasWang MinghuiHo LapShackleton BenNeff RyanWang ErmingTu ZhidongGandy SamHaroutunian VahramEhrlich Michelle EMobbs CharlesZhang Bin - Aortic dissection (AD) is a life-threatening vascular condition characterized by acute inflammation and structural deterioration of the aortic wall. This study aimed to delineate the immune landscape, particularly T cell-mediated responses, and identify conserved inflammatory mechanisms driving AD pathogenesis across human and murine models. - Source: PubMed
Publication date: 2026/07/11
Zhang ShenZhang YongguiSun YaodongZhu MinfangWu Naishi - Lung adenocarcinoma (LUAD), the predominant histological subtype of non-small cell lung cancer, remains a leading cause of cancer-related mortality worldwide. The RAS signaling pathway plays a critical role in LUAD pathogenesis; however, the heterogeneity of RAS pathway activity and its clinical implications remain poorly understood. This study aimed to characterize RAS pathway activity subtypes and develop a robust prognostic model for LUAD patients. - Source: PubMed
Publication date: 2026/05/28
Shi Yao