Ask about this productRelated genes to: ENOPH1 antibody
- Gene:
- ENOPH1 NIH gene
- Name:
- enolase-phosphatase 1
- Previous symbol:
- -
- Synonyms:
- MASA, E1, mtnC
- Chromosome:
- 4q21.22
- Locus Type:
- gene with protein product
- Date approved:
- 2007-01-26
- Date modifiied:
- 2016-10-05
Related products to: ENOPH1 antibody
Related articles to: ENOPH1 antibody
- Poultry egg production is shaped by the intertwined action of multiple physiological systems, greatly magnifying the complexity of its underlying genetic regulation. Although multitissue mapping of regulatory variants offers a powerful route to untangle this complexity, comprehensive data sets in ducks remain scarce. Meanwhile, the contributions of peripheral systems beyond neuroendocrine regulation on poultry egg production are still largely unexplored. Here, we generate 979 RNA-seq samples from the liver, ovary, oviduct shell gland, and spleen, along with matched whole-genome sequencing data from 307 egg-laying ducks. We map -regulatory variants associated with gene expression (eQTL), alternative splicing (sQTL), and 3' alternative polyadenylation (apaQTL), yielding 14,074, 6267, and 4994 genes with at least one significant eQTL, sQTL, and apaQTL, respectively. By integrating this resource and GWAS results, we confirm that expression in the shell gland specifically regulates eggshell color, with additional involvement of 's 3'APA sites in both the shell gland and liver. In addition, expression of and in the shell gland, of in the ovary, and of in the spleen is causally linked to declining egg production at peak laying. Last, we delineate a cross-tissue regulatory landscape underlying duck egg production and identify liver-derived modules, particularly Liver_ME1, which is mainly involved in cell cycle regulation, as central hubs coordinating with peripheral tissues affecting duck egg production. This work delivers a key resource and fresh perspectives for the genetic mechanism dissection of duck egg production and for future studies on cross-tissue regulation of reproduction. - Source: PubMed
Publication date: 2025/10/01
Xi YangQi JingjingYang ZhaoZeng YutianZhang HuicongTao QiuyuXu MengruHuang AnqiHu ShenqiangHan ChunchunBai LiliHu JiweiWang JiwenLi LiangFang LingzhaoLiu Hehe - Sulfur metabolism plays a crucial role in the initiation and progression of cancer. Our objective is to elucidate the molecular diversity inherent in breast cancer and to develop a predictive index grounded in sulfur metabolism-related genes (SMRGs). - Source: PubMed
Publication date: 2025/06/27
Lu JieFang QiongyanLiu XiaofengZheng Huaiyu - Enolase-phosphatase 1 (ENOPH1) is a newly identified enzyme associated with stress responses and neurodevelopmental disorders. Our previous study found that ENOPH1 mediates cerebral cell apoptosis and blood-brain barrier (BBB) dysfunction during early cerebral ischemia. Ubiquitination has been identified in neuronal damage and the neuroinflammatory response in ischemic stroke. However, whether ENOPH1 regulates ischemia-induced protein ubiquitination alteration is yet unclear. Hence, the present study explored changes in the ubiquitinomic in early ischemic brain tissues between wildtype and ENOPH1 knockout mice using a comprehensive quantitative analysis. Our results showed that 4000 ubiquitination-modified sites in 1613 proteins were quantified, with 772 ubiquitinated sites in 464 proteins significantly decreasing or increasing after ENOPH1 knockout (fold change >1.5 or <1/1.5, < 0.05). When compared to our previous parallel proteome profiles, common differential proteins FKBP5 and Claudin-11 were observed and further validated. ENOPH1 regulates the degradation of FKBP5 and the promotion of Claudin-11 by ubiquitination mediation, leading to the activation or inhibition of nuclear-initiated steroid signaling and transendothelial migration pathways. These findings, for the first time, identified ubiquitinomic features of early ischemic brain tissues after ENOPH1 knockout, suggesting that ENOPH1 may regulate neuroinflammatory stress and barrier function by modifying FKBP5 and Claudin-11 protein ubiquitination. - Source: PubMed
Publication date: 2025/04/01
Wu YikeTang PingHuang ZhengzhengGu DayongYan DewenSu LiZhang Yuan - ENOPH1 (Enolase-phosphatase 1), a member of the HAD-like hydrolase superfamily, has been linked to a range of physiological conditions, including neurological disorders. However, its involvement in tumorigenesis remains underexplored. This study is the first to conduct a pan-cancer analysis of ENOPH1, aiming to elucidate its role in multiple cancers through various bioinformatics platforms. - Source: PubMed
Publication date: 2025/02/15
Zhang XuezhongLi NingChu TingtingZhao HaijunLiu Tonggang - The study aimed to explore the role of metabolism-related proteins and their correlation with clinical data in predicting the prognosis of polycystic ovary syndrome (PCOS). - Source: PubMed
Publication date: 2024/12/19
Ding NanWang RuifangWang PeiliWang Fang